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Results: 18
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist.
Lior Soday, Yongxu Lu, Jonas D Albarnaz, Colin TR Davies, Robin Antrobus, Geoffrey L Smith, Michael P Weekes
Apr 16, 2019
Histone deacetylase host-pathogen interaction Immune Evasion innate immunity interferon Poxvirus quantitative proteomics restriction factor systems virology tandem mass tag Cytomegalovirus Down-Regulation Gene Expression Regulation Viral Herpesvirus 1 Human Histone Deacetylases Host-Pathogen Interactions Humans Immune Evasion Interferons Membrane Proteins Proteasome Endopeptidase Complex Proteolysis Proteomics Time Factors Vaccinia vaccinia virus Viral Proteins
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.
Ningguo Gao, Jie Shang, Dang Huynh, Vijaya L Manthati, Carolina Arias, Heather P Harding, Randal J Kaufman, Ian Mohr, David Ron, John R Falck, Mark A Lehrman
Aug 11, 2017
Amides Aminoacridines Animals CHO Cells Congenital Disorders of Glycosylation Cricetinae Dolichol Phosphates Endoplasmic reticulum stress FIBROBLASTS Fluorescent Dyes Glycogen Glycogen Phosphorylase Herpes Simplex Herpesvirus 1 Human Host-Pathogen Interactions Immunity Cellular Indoles Lipopolysaccharides Mannosephosphates Mice Mice Knockout Phosphotransferases (Phosphomutases) Polysaccharides Unfolded Protein Response eIF-2 Kinase
The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection.
Ben J Trigg, Katharina B Lauer, Paula Fernandes Dos Santos, Heather Coleman, Gabriel Balmus, Daniel S Mansur, Brian J Ferguson
Jun 08, 2018
Herpes simplex virus 1 (HSV-1) has extensive interactions with the host DNA damage response (DDR) machinery that can be either detrimental or beneficial to the virus. Proteins in the homologous recombination pathway are known to...
pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread.
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Oct 15, 2021
Structural analysis of herpes simplex virus by optical super-resolution imaging.
Romain F Laine, Anna Albecka, Sebastian van de Linde, Eric J Rees, Colin M Crump, Clemens F Kaminski
Jan 30, 2015
Animals Antibodies Monoclonal Cell Line Cryoelectron Microscopy Female Herpesvirus 1 Human Humans Image Processing Computer-Assisted Keratinocytes Mice Mice Inbred BALB C Microscopy Microscopy Fluorescence Optical Imaging Recombinant Proteins Simplexvirus Viral Envelope Proteins Viral Proteins Viral Structural Proteins Virion
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection.
Kamal L Nahas, Viv Connor, Katharina M Scherer, Clemens F Kaminski, Maria Harkiolaki, Colin M Crump, Stephen C Graham
Aug 07, 2022
Integrative functional genomics decodes herpes simplex virus 1.
Adam W Whisnant, Christopher S Jürges, Thomas Hennig, Emanuel Wyler, Bhupesh Prusty, Andrzej J Rutkowski, Anne L'Hernault, Lara Djakovic, Margarete Göbel, Kristina Döring, Jennifer Menegatti, Robin Antrobus, Nicholas J Matheson, Florian WH Künzig, Guido Mastrobuoni, Chris Bielow, Stefan Kempa, Chunguang Liang, Thomas Dandekar, Ralf Zimmer, Markus Landthaler, Friedrich Grässer, Paul J Lehner, Caroline C Friedel, Florian Erhard, Lars Dölken
Jun 26, 2020
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair...
Widespread disruption of host transcription termination in HSV-1 infection.
Andrzej J Rutkowski, Florian Erhard, Anne L'Hernault, Thomas Bonfert, Markus Schilhabel, Colin Crump, Philip Rosenstiel, Stacey Efstathiou, Ralf Zimmer, Caroline C Friedel, Lars Dölken
May 21, 2015
Alternative Splicing Codon Terminator Culture Media Exons FIBROBLASTS Gene Expression Regulation Viral Genes Viral Genome Viral Herpes Simplex Herpesvirus 1 Human Humans Introns Open Reading Frames Poly A Protein Biosynthesis RNA RNA Messenger Ribosomes Time Factors Transcription Genetic Virus Replication
Risk factors for herpes simplex virus type-1 infection and reactivation
Harriet Forbes, Ben Warne, Lars Doelken, Nicole Brenner, Tim Waterboer, Robert Luben, Nicholas J Wareham, Charlotte Warren-Gash, Effrossyni Gkrania-Klotsas
May 15, 2019
BACKGROUND: The prevalence of, and risk factors for, herpes simplex virus type-1 (HSV-1) infection and reactivation in older individuals are poorly understood. METHODS: This is a prospective population-based study among...
Insights into herpesvirus assembly from the structure of the pUL7
Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch, Colin M Crump, Stephen C Graham
May 11, 2020
focal adhesions human cytomegalovirus (HCMV) infectious disease microbiology molecular biophysics secondary envelopment small-angle X-ray scattering (SAXS) structural biology Virus virus budding HEK293 Cells HeLa Cells Herpes Simplex Herpesvirus 1 Human Humans Models Molecular Phosphoproteins Protein Binding Protein Interaction Domains and Motifs Protein Structure Quaternary Protein Structure Tertiary Viral Matrix Proteins Viral Proteins Virus Assembly Virus Replication trans-Golgi Network
Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.
Timothy K Soh, Colin TR Davies, Julia Muenzner, Leah M Hunter, Henry G Barrow, Viv Connor, Clément R Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C Graham, Michael P Weekes, Colin M Crump
Sep 16, 2020
Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1)...
Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus.
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock.
Rachel S Edgar, Alessandra Stangherlin, Andras D Nagy, Michael P Nicoll, Stacey Efstathiou, John S O'Neill, Akhilesh B Reddy
Aug 12, 2016
Circadian clock herpes Influenza Virus ARNTL Transcription Factors Animals Biological Transport CLOCK Proteins Cell Line Chromatin Assembly and Disassembly Circadian Clocks Circadian Rhythm Cricetinae Epithelial Cells Female Gene Expression Regulation Genes Reporter Herpes Simplex Herpesviridae Infections Herpesvirus 1 Human Host-Pathogen Interactions Influenza A virus H1N1 Subtype Luciferases Mice Mice Knockout Orthomyxoviridae Infections Rhadinovirus Tumor Virus Infections Virus Replication
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Yongxu Lu, Jennifer H Stuart, Callum Talbot-Cooper, Shuchi Agrawal-Singh, Brian Huntly, Andrei I Smid, Joseph S Snowden, Liane Dupont, Geoffrey L Smith
May 10, 2019
STAT2 recruitment histone deactylase 4 Immune Evasion type I interferon signaling vaccinia virus protein C6 Cell Line Cell Line Tumor DNA Viruses HEK293 Cells HeLa Cells Herpesvirus 1 Human Histone Deacetylases Humans Interferon Type I Repressor Proteins Signal Transduction Vaccinia vaccinia virus Viral Proteins Virus Replication
A fluorescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication.
Katharina M Scherer, James D Manton, Timothy K Soh, Luca Mascheroni, Vivienne Connor, Colin M Crump, Clemens F Kaminski
Jan 07, 2021
Herpesviruses are large and complex viruses that have a long history of coevolution with their host species. One important factor in the virus-host interaction is the alteration of intracellular morphology during viral...
Cytoskeleton Fluorescence herpesvirus host–pathogen interaction microscopic imaging Microscopy Organelle Animals Capsid Chlorocebus aethiops Cytoplasm Genes Reporter Golgi Apparatus Herpesvirus 1 Human Humans Microscopy Fluorescence Single-Cell Analysis Spatio-Temporal Analysis Vero Cells Virus Assembly Virus Replication