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Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification.
Robert E White, Ian J Groves, Ernest Turro, Jade Yee, Elisabeth Kremmer, Martin J Allday
Feb 01, 2021
Epstein-Barr virus (EBV) is able to drive the transformation of B-cells, resulting in the generation of lymphoblastoid cell lines (LCLs) in vitro. EBV nuclear proteins EBNA3A and EBNA3C are necessary for efficient...
Antigens Viral Cell Line Tumor Chromatin Cluster Analysis Epigenomics Epstein-Barr Virus Nuclear Antigens Gene Expression Profiling Gene Knockout Techniques HEK293 Cells Herpesvirus 4 Human Host-Pathogen Interactions Humans Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction
Use of rituximab in SARS-CoV-2-positive renal transplant recipient with EBV reactivation and probable haemophagocytic lymphohistiocytosis.
We present a case of a rapid clinical recovery in a critically ill kidney transplant recipient with SARS-CoV-2 positivity, Epstein-Barr virus (EBV) reactivation and probable secondary hemophagocytic lymphohistiocytosis (HLH)...
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Thomas Sommermann, Tomoharu Yasuda, Jonathan Ronen, Tristan Wirtz, Timm Weber, Ulrike Sack, Rebecca Caeser, Jingwei Zhang, Xun Li, Van Trung Chu, Anna Jauch, Kristian Unger, Daniel J Hodson, Altuna Akalin, Klaus Rajewsky
Jun 15, 2020
Epstein-Barr virus (EBV) is a B cell transforming virus that causes B cell malignancies under conditions of immune suppression. EBV orchestrates B cell transformation through its latent membrane proteins (LMPs) and Epstein-Barr...
B cell lymphomagenesis EBNA Epstein-Barr virus LMP1 plasma cell differentiation Animals Cell Differentiation Cell Line Tumor Cell Transformation Viral DNA-Binding Proteins Disease Models Animal Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens FIBROBLASTS Herpesvirus 4 Human Humans Lymphoma B-Cell Mice Mice Knockout Plasma Cells Primary Cell Culture Trans-Activators Viral Matrix Proteins Viral Proteins
Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.
Charlotte J Houldcroft, Velislava Petrova, Jimmy Z Liu, Dan Frampton, Carl A Anderson, Astrid Gall, Paul Kellam
Nov 30, 2018
Lymphoblastoid cell lines (LCLs) are commonly used in molecular genetics, supplying DNA for the HapMap and 1000 Genomes Projects, used to test chemotherapeutic agents, and informing the basis of a number of population genetics...
ADA2 deficiency complicated by EBV-driven lymphoproliferative disease.
Emily Staples, Ilenia Simeoni, Jonathan C Stephens, Hana Lango Allen, NIHR-BioResource, Penny Wright, E Graham Davies, Babak Javid, Effrossyni Gkrania-Klotsas, Michael Gattens, Helen Firth, Olga Shamardina, Sri VV Deevi, Matina Prapa, Ben Uttenthal, Dinakantha Kumararatne, James ED Thaventhiran
May 14, 2020
A 29-year old male with recurrent respiratory and skin infections, anaemia and neutropaenia during childhood required immunoglobulin replacement for antibody deficiency from age 16. He remained relatively well until age 28 when...
Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival.
Liang Wei Wang, Zhonghao Wang, Ina Ersing, Luis Nobre, Rui Guo, Sizun Jiang, Stephen Trudeau, Bo Zhao, Michael P Weekes, Benjamin E Gewurz
Aug 19, 2019
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis of multiple lymphomas. Yet, knowledge of how EBV...
Alkyl and Aryl Transferases B-Lymphocytes Cell Proliferation Cell Survival Cholesterol Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Fatty Acids Herpesvirus 4 Human Host Microbial Interactions Humans Metabolic Networks and Pathways Mevalonic Acid Proto-Oncogene Proteins c-myc Sterol Regulatory Element Binding Protein 2 Viral Proteins rab GTP-Binding Proteins
Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria.
Vanessa Daza-Cajigal, Adriana S Albuquerque, Dan F Young, Michael J Ciancanelli, Dale Moulding, Ivan Angulo, Valentine Jeanne-Julien, Jérémie Rosain, Ekaterina Minskaia, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Richard E Randall, Timothy D McHugh, Adrian J Thrasher, Siobhan O Burns
Oct 28, 2022
PURPOSE: Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection...
Identification of the viral molecules recognised by influenza specific human cytoxic T lymphocytes.
Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1...
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections.
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O Pollard, Alexander T Dilthey, Alexander J Mentzer, Vickie Marshall, Elena M Cornejo Castro, Cristina Pomilla, Elizabeth H Young, Gershim Asiki, Martin L Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Oct 02, 2020
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is...
Adolescent Adult Antibodies Viral Antigens Viral Capsid Proteins Coinfection Disease Resistance Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Gene Expression Genome-Wide Association Study HIV HLA-DQ alpha-Chains Henipavirus Infections Herpesvirus 4 Human Herpesvirus 8 Human Host-Pathogen Interactions Humans Incidence Male Middle Aged Rural Population Sarcoma Kaposi Uganda Urban Population