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Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation.
HHV-8 KSHV NK cell receptor ligands herpesvirus host cell restriction factors lytic reactivation Proteomics Viral immune evasion Antigens Differentiation T-Lymphocyte Cell Line DNA-Directed DNA Polymerase Down-Regulation Endothelial Cells Gene Library Gene Ontology Genes Viral Genetic Testing Herpesvirus 8 Human Humans immunomodulation Kinetics Ligands Mutation Proteome Proteomics Sarcoma Kaposi Up-Regulation Viral Proteins Virus Activation eIF-2 Kinase
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
Hannah J Durrington, Paul D Upton, Simon Hoer, Jessica Boname, Benjamin J Dunmore, Jun Yang, Trina K Crilley, Lynn M Butler, David J Blackbourn, Gerard B Nash, Paul J Lehner, Nicholas W Morrell
Aug 28, 2020
Bone morphogenetic proteins (BMPs) are critically involved in early development and cell differentiation. In humans, dysfunction of the bone morphogenetic protein type II receptor (BMPR-II) is associated with pulmonary arterial...
Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination.
Neneh Sallah, Anne L Palser, Simon J Watson, Nazzarena Labo, Gershim Asiki, Vickie Marshall, Robert Newton, Denise Whitby, Paul Kellam, Inês Barroso
Jul 26, 2019
BACKGROUND: Kaposi sarcoma-associated herpesvirus (KSHV) establishes lifelong infection in the human host and has been associated with a variety of malignancies. KSHV displays striking geographic variation in prevalence, which...
A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.
Michael DJ Parkinson, Siân C Piper, Nicholas A Bright, Jennifer L Evans, Jessica M Boname, Katherine Bowers, Paul J Lehner, J Paul Luzio
Jul 30, 2015
Endocytosis endosomal sorting complex required for transport (ESCRT) histidine domain phosphotyrosine phosphatase (HD-PTP) histidine-domain protein tyrosine phosphatase non-receptor type 23 (PTPN23) lysosome ubiquitination (ubiquitylation) Down-Regulation Endosomal Sorting Complexes Required for Transport HeLa Cells Herpesvirus 8 Human Histocompatibility Antigens Class I Humans Protein Tyrosine Phosphatases Non-Receptor Ubiquitination Viral Proteins
Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections.
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O Pollard, Alexander T Dilthey, Alexander J Mentzer, Vickie Marshall, Elena M Cornejo Castro, Cristina Pomilla, Elizabeth H Young, Gershim Asiki, Martin L Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Oct 02, 2020
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is...
Adolescent Adult Antibodies Viral Antigens Viral Capsid Proteins Coinfection Disease Resistance Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Gene Expression Genome-Wide Association Study HIV HLA-DQ alpha-Chains Henipavirus Infections Herpesvirus 4 Human Herpesvirus 8 Human Host-Pathogen Interactions Humans Incidence Male Middle Aged Rural Population Sarcoma Kaposi Uganda Urban Population
Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy.
Claire Bagnéris, Kacper B Rogala, Mehdi Baratchian, Vlad Zamfir, Micha BA Kunze, Selina Dagless, Katharina F Pirker, Mary K Collins, Benjamin A Hall, Tracey E Barrett, Christopher WM Kay
Sep 05, 2018
Viral flice-interacting protein (vFLIP), encoded by the oncogenic Kaposi sarcoma-associated herpes virus (KSHV), constitutively activates the canonical nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway....
IKKγ NEMO NF-kappa B (NF-κB) electron paramagnetic resonance (EPR) Molecular dynamics molecular modeling Protein Structure signalosome vFLIP Virology Amino Acid Motifs Binding Sites Electron Spin Resonance Spectroscopy Herpesvirus 8 Human Humans I-kappa B Kinase Protein Binding Sarcoma Kaposi Viral Proteins