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Plants continuously extend their root and shoot systems through the action of meristems at their growing tips. By regulating which meristems are active, plants adjust their body plans to suit local environmental conditions. The...

Arabidopsis Arabidopsis Proteins Biological Transport Cell Membrane Clathrin Computer Simulation Gene Expression Regulation Plant Heterocyclic Compounds 3-Ring Indoleacetic Acids Lactones Membrane Transport Proteins Meristem Plant Growth Regulators Plant Roots Plant Shoots Plant Stems Signal Transduction Xylem

Adult Aged Aged 80 and over Animals Antineoplastic Combined Chemotherapy Protocols Benzimidazoles Cell Line Tumor Female Heterocyclic Compounds 3-Ring Humans MAP Kinase Kinase Kinases Male Mice Middle Aged Neoplasms Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins p21(ras) Xenograft Model Antitumor Assays ras Proteins

Amides Aza Compounds Heterocyclic Compounds 3-Ring Models Molecular Molecular Conformation Stereoisomerism

Heterocyclic Compounds 3-Ring Lactones Models Molecular Multienzyme Complexes Oryza Plant Growth Regulators Plant Proteins Protein Binding Protein Structure Secondary SKP Cullin F-Box Protein Ligases Signal Transduction Structure-Activity Relationship Ubiquitin Ubiquitination

PURPOSE: Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown activity in relapsed or refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). PI3K inhibitors have been hampered by poor long-term tolerability and toxicity...

Female Heterocyclic Compounds 4 or More Rings Humans Lymphoma Male Neoplasm Recurrence Local

AMD3100 CXCR4 colorectal cancer Immunotherapy pancreatic cancer Aged Benzylamines Carcinoma Pancreatic Ductal Chemokine CXCL12 Colorectal Neoplasms Cyclams Female Heterocyclic Compounds Humans Immunity Immunotherapy Male Middle Aged Pancreas Pancreatic Neoplasms Receptors CCR2 Receptors CXCR3 Receptors CXCR4 Receptors CXCR5 Receptors CXCR6 Receptors Interleukin-8A Signal Transduction Tumor Microenvironment

OBJECTIVES: The WHO recently recommended the use of a new first-line ART containing dolutegravir. We investigated the efficacy of NRTI backbones (tenofovir or abacavir with a cytosine analogue) in low- and middle-income...

Adult Anti-HIV Agents Antiretroviral Therapy Highly Active Cytosine Dideoxynucleosides Drug Combinations Drug Resistance Viral Female HIV Infections HIV Integrase Inhibitors HIV-1 Heterocyclic Compounds 3-Ring Humans Male Middle Aged Mutation Oxazines Piperazines Pyridones South Africa Tenofovir Viral Load Young Adult

Stimulated emission depletion (STED) nanoscopy allows observations of subcellular dynamics at the nanoscale. Applications have, however, been severely limited by the lack of a versatile STED-compatible two-colour labelling...

Animals COS Cells Chlorocebus aethiops HeLa Cells Heterocyclic Compounds 4 or More Rings Humans Luminescent Proteins Microscopy Fluorescence Nanotechnology Rhodamines

Amino Acid Sequence Animals Heterocyclic Compounds 1-Ring Humans Ligands Molecular Imaging Molecular Sequence Data Peptides Protein Binding Receptor Cholecystokinin B

adenine Adult Alanine Amides Antiretroviral Therapy Highly Active BNT162 Vaccine CD4 Lymphocyte Count CD4-CD8 ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes covid-19 COVID-19 Vaccines Emtricitabine HIV Infections HIV-1 Heterocyclic Compounds 3-Ring Heterocyclic Compounds 4 or More Rings Humans Neutralization Tests Piperazines Pyridones RNA Viral SARS-CoV-2 Tenofovir Treatment Failure

BACKGROUND: The integrase inhibitor dolutegravir is being considered in several countries in sub-Saharan Africa instead of efavirenz for people initiating antiretroviral therapy (ART) because of superior tolerability and a lower...

Adolescent Adult Africa South of the Sahara Alkynes Anti-HIV Agents Benzoxazines Cost-Benefit Analysis Cyclopropanes Female HIV Infections Heterocyclic Compounds 3-Ring Humans Infectious Disease Transmission Vertical Male Middle Aged Oxazines Piperazines Practice Guidelines as Topic Pregnancy Pregnancy Complications Pyridones Randomized Controlled Trials as Topic Young Adult

Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and it may promote the progression of atherosclerosis, but the mechanisms behind this process are not completely understood. We previously showed that the...

Apolipoprotein A-I Cholesterol Enzyme Activation Heterocyclic Compounds 3-Ring Humans Lipoprotein Lipase MACROPHAGES Palmitic Acid Phosphorylation Proto-Oncogene Proteins c-akt THP-1 Cells

Benzimidazoles Bridged-Ring Compounds density functional theory Heterocyclic Compounds 3-Ring Imidazoles Models Chemical Support Vector Machine

Strained alkenes and alkynes are the predominant dienophiles used in inverse electron demand Diels-Alder (IEDDA) reactions. However, their instability, cross-reactivity, and accessibility are problematic. Unstrained dienophiles...

Boron Compounds Cycloaddition Reaction Fluorescent Dyes Heterocyclic Compounds Molecular Structure

Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that...

CSF1R T cells MACROPHAGES pancreatic cancer Adult Aniline Compounds Animals Carcinoma Pancreatic Ductal Cell Line Tumor Female Heterocyclic Compounds 2-Ring Humans Immunity Cellular MACROPHAGES Male Mice Models Immunological Neoplasm Proteins Pancreatic Neoplasms Receptors Granulocyte-Macrophage Colony-Stimulating Factor T-Lymphocytes Xenograft Model Antitumor Assays

Arabidopsis Arabidopsis Proteins Furans Gene Expression Regulation Plant germination Heterocyclic Compounds 3-Ring Homozygote Intracellular Signaling Peptides and Proteins Lactones Multigene Family Mycorrhizae Oryza Phylogeny Plant Proteins Plant Roots Pyrans RNA-seq Signal Transduction Symbiosis

In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study...

anti-inflammatory drugs bioorthogonal decaging inverse electron-demand Diels-Alder reaction tetrazine trans-cyclooctene Animals Anti-Inflammatory Agents Non-Steroidal Carboxylic Acids Cycloaddition Reaction Fluorescent Dyes Heterocyclic Compounds Ketoprofen MACROPHAGES Mice RAW 264.7 Cells

Adult Aged Antineoplastic Agents Biomarkers Diagnostic Imaging Drug Administration Schedule Drug Monitoring Female Heterocyclic Compounds 3-Ring Humans Magnetic Resonance Imaging Male Maximum Tolerated Dose Middle Aged Neoplasm Staging Neoplasms Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Treatment Outcome

Acetylation Adaptor Proteins Signal Transducing Animals Bone Density Carbazoles Cell Line Coculture Techniques Disease Models Animal Epigenesis Genetic Female Glycoproteins Heterocyclic Compounds 4 or More Rings Humans Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Inducible Factor-Proline Dioxygenases Intercellular Signaling Peptides and Proteins Male Mice Inbred C57BL Mice Transgenic Osteocytes Osteogenesis Osteoporosis Oxygen Primary Cell Culture Promoter Regions Genetic Sirtuin 1 Wnt Signaling Pathway