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DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.
Kate Joanne Howell, Judith Kraiczy, Komal M Nayak, Marco Gasparetto, Alexander Ross, Claire Lee, Tim N Mak, Bon-Kyoung Koo, Nitin Kumar, Trevor Lawley, Anupam Sinha, Philip Rosenstiel, Robert Heuschkel, Oliver Stegle, Matthias Zilbauer
Jan 24, 2018
BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis....
epigenetics Gut microbiota Human Intestinal Organoids Intestinal Epithelium Adolescent Age Factors Biopsy Case-Control Studies Colitis Ulcerative Colon Sigmoid Crohn Disease DNA Methylation Diagnosis Differential England Epigenesis Genetic Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Profiling Genome-Wide Association Study Humans Ileum Intestinal Mucosa Male Organoids Predictive Value of Tests Prognosis Prospective Studies Ribotyping Time Factors Tissue Culture Techniques Transcription Genetic Transcriptome
Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids.
Emily L Miedzybrodzka, Rachel E Foreman, Van B Lu, Amy L George, Christopher A Smith, Pierre Larraufie, Richard G Kay, Deborah A Goldspink, Frank Reimann, Fiona M Gribble
Oct 15, 2021
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu S Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Jan 06, 2022
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...
Design, development, and validation of a strand-specific RT-qPCR assay for GI and GII human Noroviruses.
Katja Marie Kjara König, Aminu Jahun, Komal Nayak, Lydia N Drumright, Matthias Zibauer, Ian Goodfellow, Myra Hosmillo
Nov 03, 2021
Human noroviruses (HuNoV) are the major cause of viral gastroenteritis worldwide. Similar to other positive-sense single-stranded RNA viruses, norovirus RNA replication requires the formation of a negative strand RNA...