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Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos.
Gregorio Alanis-Lobato, Jasmin Zohren, Afshan McCarthy, Norah ME Fogarty, Nada Kubikova, Emily Hardman, Maria Greco, Dagan Wells, James MA Turner, Kathy K Niakan
Jun 07, 2021
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable...
Human embryo polarization requires PLC signaling to mediate trophectoderm specification.
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 27, 2021
Cell Biology Cell Polarity developmental biology Human embryo preimplantation Actins Adult Body Patterning Cell Differentiation Cell Lineage Cell Polarity Embryo Culture Techniques Embryo Mammalian Female GATA3 Transcription Factor Gene Expression Regulation Developmental Gene Expression Regulation Enzymologic Humans Phosphoinositide Phospholipase C Phospholipase C beta Pregnancy Signal Transduction Time Factors Young Adult
Human embryo polarization requires PLC signaling to mediate trophectoderm specification
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 13, 2021
Human embryo polarization requires PLC signaling to mediate trophectoderm specification.
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 28, 2021
Published by: eLife
Florence R. Sabin, 1915
The Rockefeller University
Jan 01, 0001
Prof. Florence R. Sabin. The Method of Growth of the Lymphatic System
Lecture delivered December 18th, 1915
Published by: J.B. Lippincott Company
Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation.
Naive stem cell blastocyst model captures human embryo lineage segregation.
Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and hypoblast. Here we describe a human embryo model (blastoid) generated by self-organization. Brief induction of trophectoderm leads to...