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Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression.
William Plumbly, Nikolaos Patikas, Sarah F Field, Stefanie Foskolou, Emmanouil Metzakopian
Jan 04, 2023
Despite development of protocols to differentiate human pluripotent stem cells (hPSCs), those used to produce sensory neurons remain difficult to replicate and result in heterogenous populations. There is a growing clinical...
Single-Cell Transcriptomics of Parkinson's Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses.
Hugo JR Fernandes, Nikolaos Patikas, Stefanie Foskolou, Sarah F Field, Jong-Eun Park, Meg L Byrne, Andrew R Bassett, Emmanouil Metzakopian
Sep 25, 2020
cholesterol biosynthesis Dopamine neurons ER stress Felodipine Human iPSC Oxidative Stress PD GWAS Parkinson's Disease SNCA-A53T Single-cell transcriptomics Cell Differentiation Cell Respiration Cholesterol Chromatin Assembly and Disassembly Dopaminergic Neurons Down-Regulation Endoplasmic reticulum stress Gene Expression Profiling Genome-Wide Association Study Glycolysis Humans Induced Pluripotent Stem Cells Models Biological Oxidative Phosphorylation Oxidative Stress Parkinson Disease Proteasome Endopeptidase Complex Regression Analysis Signal Transduction Single-Cell Analysis Stress Physiological Synapses Transcriptome Ubiquitin Up-Regulation