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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.
Michael A Jacobetz, Derek S Chan, Albrecht Neesse, Tashinga E Bapiro, Natalie Cook, Kristopher K Frese, Christine Feig, Tomoaki Nakagawa, Meredith E Caldwell, Heather I Zecchini, Martijn P Lolkema, Ping Jiang, Anne Kultti, Curtis B Thompson, Daniel C Maneval, Duncan I Jodrell, Gregory I Frost, HM Shepard, Jeremy N Skepper, David A Tuveson
Sep 03, 2020
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix...
Animals Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Carcinoma Pancreatic Ductal Cell Adhesion Molecules Deoxycytidine Doxorubicin Drug Delivery Systems Drug Resistance Neoplasm Hyaluronic Acid Hyaluronoglucosaminidase Immunohistochemistry Kaplan-Meier Estimate Mice Mice Transgenic Pancreatic Neoplasms Recombinant Proteins Tissue Array Analysis Treatment Outcome Gemcitabine