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Autophagy, a major degradation process for long-lived and aggregate-prone proteins, affects various human processes, such as development, immunity, cancer, and neurodegeneration. Several autophagy regulators have been identified...

Animals Apoptosis Regulatory Proteins Autophagy Beclin-1 Cell Line Class III Phosphatidylinositol 3-Kinases Enzyme Inhibitors HEK293 Cells HeLa Cells Humans Huntingtin Protein Huntington Disease I-kappa B Kinase Mechanistic Target of Rapamycin Complex 1 Membrane Proteins Mice Mitogen-Activated Protein Kinase 8 Multiprotein Complexes NG-Nitroarginine Methyl Ester Nerve Tissue Proteins Nitric oxide nitric oxide synthase Nuclear Proteins Phosphorylation Protein Isoforms Proteins Proto-Oncogene Proteins c-bcl-2 Rats TOR Serine-Threonine Kinases Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins

Cells must adapt to changes in their environment to maintain cell, tissue and organismal integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF-κB) is one of the most important...

IKKs IκBs decoy receptors deubiquitylases Feedback nuclear factor κB Animals Cell Survival Feedback Physiological Gene Expression Regulation Humans I-kappa B Kinase Inflammation NF-kappa B Phosphorylation RNA Stability Signal Transduction

The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and IKKbeta are highly similar catalytic subunits, both capable of IkappaB phosphorylation in vitro, IKKgamma...

Animals Apoptosis Base Sequence DNA Primers Female I-kappa B Kinase interleukin-1 Liver Mice Mice Knockout NF-kappa B Phenotype Pregnancy Protein Conformation Protein Serine-Threonine Kinases Signal Transduction Tumor Necrosis Factor-alpha

Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome...

Alzheimer's Disease CFAS Dementia HUMAN BRAIN metaflammasome Aged Aged 80 and over Alzheimer Disease Apolipoproteins E Cohort Studies Diabetes mellitus Type 2 Female Humans I-kappa B Kinase Immunohistochemistry Insulin Receptor Substrate Proteins MAP Kinase Kinase 4 Male Mental Status Schedule Neocortex Phosphorylation Polymorphism Genetic Risk Factors eIF-2 Kinase

Viral flice-interacting protein (vFLIP), encoded by the oncogenic Kaposi sarcoma-associated herpes virus (KSHV), constitutively activates the canonical nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway....

IKKγ NEMO NF-kappa B (NF-κB) electron paramagnetic resonance (EPR) Molecular dynamics molecular modeling Protein Structure signalosome vFLIP Virology Amino Acid Motifs Binding Sites Electron Spin Resonance Spectroscopy Herpesvirus 8 Human Humans I-kappa B Kinase Protein Binding Sarcoma Kaposi Viral Proteins

innate immunity nuclear factor kappa B vaccinia virus virus immune evasion Feedback Physiological Humans I-kappa B Kinase I-kappa B Proteins Molecular Mimicry NF-kappa B Phosphoproteins Phosphorylation Signal Transduction Ubiquitin-Protein Ligases Ubiquitination vaccinia virus Viral Proteins Virulence beta-Transducin Repeat-Containing Proteins

Human cytomegalovirus (HCMV), a β-herpesvirus, has evolved many strategies to subvert both innate and adaptive host immunity in order to ensure its survival and propagation within the host. Induction of IL-8 is particularly...

Ataxia Telangiectasia Mutated Proteins Cell Line Cell Nucleus Cytomegalovirus Cytomegalovirus Infections DNA Damage Genes Reporter Host-Pathogen Interactions Humans I-kappa B Kinase Interleukin-8 Mutation Protein Transport Proteolysis RNA Interference Recombinant Proteins Signal Transduction Trans-Activators Transcription Factor RelA Up-Regulation Virus Replication