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Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria.
Vanessa Daza-Cajigal, Adriana S Albuquerque, Dan F Young, Michael J Ciancanelli, Dale Moulding, Ivan Angulo, Valentine Jeanne-Julien, Jérémie Rosain, Ekaterina Minskaia, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Richard E Randall, Timothy D McHugh, Adrian J Thrasher, Siobhan O Burns
Sep 23, 2022
Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria.
Vanessa Daza-Cajigal, Adriana S Albuquerque, Dan F Young, Michael J Ciancanelli, Dale Moulding, Ivan Angulo, Valentine Jeanne-Julien, Jérémie Rosain, Ekaterina Minskaia, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Richard E Randall, Timothy D McHugh, Adrian J Thrasher, Siobhan O Burns
Oct 28, 2022
PURPOSE: Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection...