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Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
Jil Sander, Susanne V Schmidt, Branko Cirovic, Naomi McGovern, Olympia Papantonopoulou, Anna-Lena Hardt, Anna C Aschenbrenner, Christoph Kreer, Thomas Quast, Alexander M Xu, Lisa M Schmidleithner, Heidi Theis, Lan Do Thi Huong, Hermi Rizal Bin Sumatoh, Mario AR Lauterbach, Jonas Schulte-Schrepping, Patrick Günther, Jia Xue, Kevin Baßler, Thomas Ulas, Kathrin Klee, Natalie Katzmarski, Stefanie Herresthal, Wolfgang Krebs, Bianca Martin, Eicke Latz, Kristian Händler, Michael Kraut, Waldemar Kolanus, Marc Beyer, Christine S Falk, Bettina Wiegmann, Sven Burgdorf, Nicholas A Melosh, Evan W Newell, Florent Ginhoux, Andreas Schlitzer, Joachim L Schultze
Mar 07, 2018
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and...
IL-4 IL-4 activated macrophages M(IL-4) NCOR2 activation human inflammatory dendritic cells inflammatory macrophages MACROPHAGES monocyte-derived dendritic cells Monocytes Cell Differentiation Cell Lineage Dendritic Cells Gene Expression Profiling Gene Expression Regulation Granulocyte-Macrophage Colony-Stimulating Factor Humans Immunophenotyping Interleukin-4 Macrophage Activation Macrophage Colony-Stimulating Factor MACROPHAGES Monocytes Nuclear Receptor Co-Repressor 2 Primary Cell Culture Signal Transduction Time Factors Transcription Genetic