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Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.
Amelia T Soderholm, Timothy C Barnett, Othmar Korn, Tania Rivera-Hernandez, Lisa M Seymour, Benjamin L Schulz, Victor Nizet, Christine A Wells, Matthew J Sweet, Mark J Walker
Apr 14, 2021
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adults, with severe invasive disease and immune sequelae being an infrequent consequence. The ability of GAS to invade the host and...
IL-8 protease PrtS ScpC Streptococcus pyogenes intracellular infection Chemokines Cytokines Cytoplasm Epithelial Cells Gene Expression Host-Pathogen Interactions Humans Immunity Innate Interleukin-8 Male Palatine Tonsil Peptide Hormones Protein Transport Streptococcal Infections Streptococcus pyogenes Transcription Factors