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Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.
Alzheimer’s disease IL1β LIPOPOLYSACCHARIDE Microglia Organotypic hippocampal slice culture Presynaptic synapse Synaptophysin Animals Brain Inflammation Inflammation Mediators Interleukin-1beta Lipopolysaccharides Mice Mice Inbred C57BL Microglia Organ Culture Techniques Presynaptic Terminals Synapses