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Results: 11
SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa.
Adam Abdullahi, David Oladele, Michael Owusu, Steven A Kemp, James Ayorinde, Abideen Salako, Douglas Fink, Fehintola Ige, Isabella ATM Ferreira, Bo Meng, Augustina Angelina Sylverken, Chika Onwuamah, Kwame Ofori Boadu, Kazeem Osuolale, James Opoku Frimpong, Rufai Abubakar, Azuka Okuruawe, Haruna Wisso Abdullahi, Gideon Liboro, Lawrence Duah Agyemang, Nana Kwame Ayisi-Boateng, Oluwatosin Odubela, Gregory Ohihoin, Oliver Ezechi, Japhet Senyo Kamasah, Emmanuel Ameyaw, Joshua Arthur, Derrick Boakye Kyei, Dorcas Ohui Owusu, Olagoke Usman, Sunday Mogaji, Adedamola Dada, George Agyei, Soraya Ebrahimi, Lourdes Ceron Gutierrez, Sani H Aliyu, Rainer Doffinger, Rosemary Audu, Richard Adegbola, Petra Mlcochova, Richard Odame Phillips, Babatunde Lawal Solako, Ravindra K Gupta
Nov 17, 2022
Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior...
Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST)
Alasdair PS Munro, Shuo Feng, Leila Janani, Victoria Cornelius, Parvinder K Aley, Gavin Babbage, David Baxter, Marcin Bula, Katrina Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Ehsaan Qureshi, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Nasir Kanji, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Mina Maallah, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Kyra Holliday, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Tanveer Bawa, Dinesh Saralaya, Sunil Sharma, Ray Sheridan, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay, Nick Andrews, Teresa Lambe, Jonathan S Nguyen-Van-Tam, Matthew D Snape, Xinxue Liu, Saul N Faust, COV-BOOST study group
Jun 13, 2022
BACKGROUND: Some high-income countries have deployed fourth doses of COVID-19 vaccines, but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain. We aimed to investigate the safety...
Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers.
Nathanaël Hozé, Henrik Salje, Dominique Rousset, Camille Fritzell, Jessica Vanhomwegen, Sarah Bailly, Matthieu Najm, Antoine Enfissi, Jean-Claude Manuguerra, Claude Flamand, Simon Cauchemez
Jul 27, 2020
Characterizing the circulation of Mayaro virus (MAYV), an emerging arbovirus threat, is essential for risk assessment but challenging due to cross-reactivity with other alphaviruses such as chikungunya virus (CHIKV). Here, we...
Adolescent Adult Alphavirus Infections Antibodies Viral Arboviruses Chikungunya virus Child Child Preschool Communicable Diseases Emerging Cross Reactions Cross-Sectional Studies Epidemiological Monitoring Female French Guiana Humans Immunoglobulin G Infant Male Middle Aged Rural Health Seroepidemiologic Studies Young Adult
A cross-sectional seroepidemiological survey of typhoid fever in Fiji.
Conall H Watson, Stephen Baker, Colleen L Lau, Kitione Rawalai, Mere Taufa, Jerimaia Coriakula, Nga Tran Vu Thieu, Tan Trinh Van, Dung Tran Thi Ngoc, Niel Hens, John H Lowry, Ruklanthi de Alwis, Jorge Cano, Kylie Jenkins, E Kim Mulholland, Eric J Nilles, Mike Kama, W John Edmunds
Apr 10, 2019
Fiji, an upper-middle income state in the Pacific Ocean, has experienced an increase in confirmed case notifications of enteric fever caused by Salmonella enterica serovar Typhi (S. Typhi). To characterize the epidemiology of...
Adolescent Adult Age Distribution Aged Antibodies Bacterial Child Child Preschool Cross-Sectional Studies Demography Female Fiji Humans Immunoglobulin G Infant Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Salmonella typhi Sanitation Seroepidemiologic Studies Sex Distribution Socioeconomic Factors Surveys and Questionnaires Typhoid Fever Vaccination Young Adult
Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope
Cynthia SM Kramer, Marry EI Franke-van Dijk, Ashley J Priddey, Tamás Pongrácz, Elena Gnudi, Helena Car, Gonca E Karahan, Els van Beelen, Chalana CC Zilvold-van den Oever, Hendrik J Rademaker, Noortje de Haan, Manfred Wuhrer, Vasilis Kosmoliaptsis, Paul WHI Parren, Arend Mulder, Dave L Roelen, Frans HJ Claas, Sebastiaan Heidt
Oct 29, 2019
In the field of transplantation, the humoural immune response against mismatched HLA antigens of the donor is associated with inferior graft survival, but not in every patient. Donor-specific HLA antibodies (DSA) of different...
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs
Anton M Sholukh, Jennifer D Watkins, Hemant K Vyas, Sandeep Gupta, Samir K Lakhashe, Swati Thorat, Mingkui Zhou, Girish Hemashettar, Barbara C Bachler, Donald N Forthal, Francois Villinger, Quentin J Sattentau, Robin A Weiss, Gloria Agatic, Davide Corti, Antonio Lanzavecchia, Jonathan L Heeney, Ruth M Ruprecht
Jun 12, 2015
(6 max) Complete protection IgA IgG Passive immunization Rhesus monkey SHIV-C mucosal challenge Administration Intravenous Administration mucosal Animals Antibodies Monoclonal Antibodies Neutralizing HIV Antibodies HIV-1 Humans Immunity Cellular Immunity mucosal Immunization Passive Immunoglobulin A Immunoglobulin G Macaca mulatta Mucous Membrane RNA Viral Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus T-Lymphocytes
Belimumab in kidney transplantation
Gemma D Banham, Shaun M Flint, Nicholas Torpey, Paul A Lyons, Don N Shanahan, Adele Gibson, Christopher JE Watson, Ann-Marie O'Sullivan, Joseph A Chadwick, Katie E Foster, Rachel B Jones, Luke R Devey, Anna Richards, Lars-Peter Erwig, Caroline O Savage, Kenneth GC Smith, Robert B Henderson, Menna R Clatworthy
Sep 05, 2018
Antibody responses to Schistosoma mansoni schistosomula antigens.
Moses Egesa, Lawrence Lubyayi, Frances M Jones, Angela van Diepen, Iain W Chalmers, Edridah M Tukahebwa, Bernard S Bagaya, Cornelis H Hokke, Karl F Hoffmann, David W Dunne, Alison M Elliott, Maria Yazdanbakhsh, Shona Wilson, Stephen Cose
Nov 22, 2018
While antigens from Schistosoma schistosomula have been suggested as potential vaccine candidates, the association between antibody responses with schistosomula antigens and infection intensity at reinfection is not well known....
Schistosoma mansoni IgE antibody responder Reinfection schistosomula antigens Animals Anthelmintics Antibodies Helminth Antibody Formation Antigens Helminth Enzyme-Linked Immunosorbent Assay Female Helminth Proteins Humans Immunoglobulin E Immunoglobulin G Male Praziquantel Schistosoma mansoni Schistosomiasis mansoni Uganda
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Günthard, Andreas Plückthun, Alexandra Trkola
Jan 07, 2022
The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing antibodies (bnAbs) target the V3-base. Challenging...
Increased ShTAL1 IgE responses post-Praziquantel treatment may be associated with a reduced risk to re-infection in a Ghanaian S. haematobium-endemic community.
Elias K Asuming-Brempong, Irene Ayi, William van der Puije, Ben A Gyan, Irene A Larbi, Yvonne Ashong, Naa Adjeley Frempong, Joseph K Quartey, Joseph Otchere, Frances M Jones, Shona Wilson, David W Dunne, Daniel A Boakye
Apr 09, 2022
BACKGROUND: Evidence from recent studies in Schistosoma mansoni-endemic areas show an age-associated immunity that is positively correlated with IgE titres to Schistosoma mansoni-specific tegumental allergen-like protein 1...
Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK
Xinxue Liu, Alasdair PS Munro, Shuo Feng, Leila Janani, Parvinder K Aley, Gavin Babbage, David Baxter, Marcin Bula, Katrina Cathie, Krishna Chatterjee, Wanwisa Dejnirattisai, Kate Dodd, Yvanne Enever, Ehsaan Qureshi, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Jonathan Kwok, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Kyra Holliday, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Teona Serafimova, Dinesh Saralaya, Gavin R Screaton, Sunil Sharma, Ray Sheridan, Ann Sturdy, Piyada Supasa, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay, Nick Andrews, Teresa Lambe, Jonathan S Nguyen-Van-Tam, Victoria Cornelius, Matthew D Snape, Saul N Faust, COV-BOOST study group
May 13, 2022
OBJECTIVES: To evaluate the persistence of immunogenicity three months after third dose boosters. METHODS: COV-BOOST is a multicentre, randomised, controlled, phase 2 trial of seven COVID-19 vaccines used as a third booster...
COVID-19 vaccine Fractional dose Heterologous boost Homologous boost Immunogenicity Persistence Third dose Ad26COVS1 Adult Aged Aged 80 and over Antibodies Viral BNT162 Vaccine covid-19 COVID-19 Vaccines ChAdOx1 nCoV-19 Humans Immunogenicity Vaccine Immunoglobulin G Middle Aged SARS-CoV-2 United Kingdom Viral Vaccines mRNA Vaccines