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Results: 338
Clinical prevalence of Lewy body dementia.
Joseph PM Kane, Ajenthan Surendranathan, Allison Bentley, Sally AH Barker, John-Paul Taylor, Alan J Thomas, Louise M Allan, Richard J McNally, Peter W James, Ian G McKeith, David J Burn, John O'Brien
Apr 05, 2018
Background: The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and...
Association between developmental milestones and age of schizophrenia onset
Jan Stochl, Anjalene Whittier, Adam P Wagner, Juha Veijola, Erika Jääskeläinen, Jouko Miettunen, Golam M Khandaker, Peter B Jones
Feb 22, 2019
We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later...
Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease.
Hyon Jin Jeon, Gi Deok Pak, Justin Im, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Amy Gassama Sow, Abdramane Bassiahi Soura, Nagla Gasmelseed, Karen H Keddy, Morten Bjerregaard-Andersen, Frank Konings, Abraham Aseffa, John A Crump, Yun Chon, Robert F Breiman, Se Eun Park, Ligia Maria Cruz Espinoza, Hye Jin Seo, Jürgen May, Christian G Meyer, Jason R Andrews, Ursula Panzner, Vera von Kalckreuth, Thomas F Wierzba, Raphaël Rakotozandrindrainy, Gordon Dougan, Myron M Levine, Joachim Hombach, Jerome H Kim, John D Clemens, Stephen Baker, Florian Marks
Sep 10, 2018
BACKGROUND: The World Health Organization recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons ≥6 months to 45 years residing in typhoid fever (TF)-endemic areas. We now need to consider how...
Stage-specific incidence trends of melanoma in an English region, 1996-2015
Annie Herbert, Minjoung M Koo, Matthew E Barclay, David C Greenberg, Gary A Abel, Nick J Levell, Georgios Lyratzopoulos
Sep 11, 2018
High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants.
Peter Willeit, Paul Welsh, Jonathan DW Evans, Lena Tschiderer, Charles Boachie, J Wouter Jukema, Ian Ford, Stella Trompet, David J Stott, Patricia M Kearney, Simon P Mooijaart, Stefan Kiechl, Emanuele Di Angelantonio, Naveed Sattar
Nov 16, 2018
BACKGROUND: High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury. OBJECTIVES: The goal of this study was to assess associations of cardiac...
Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam
Alessandra Berto, Jeremy Day, Nguyen Van Vinh Chau, Guy E Thwaites, Ngoc Nghiem My, Stephen Baker, Thomas C Darton
Apr 10, 2019
BACKGROUND: Hepatitis C infection is a major public health concern in low- and middle-income countries where an estimated 71.1 million individuals are living with chronic infection. The World Health Organization (WHO) has...
Perceptions of self-rated health among stroke survivors
N Mavaddat, E Sadler, L Lim, K Williams, E Warburton, AL Kinmonth, J Mant, J Burt, C McKevitt
May 29, 2018
Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women.
Ranjit Manchanda, Shreeya Patel, Vladimir S Gordeev, Antonis C Antoniou, Shantel Smith, Andrew Lee, John L Hopper, Robert J Macinnis, Clare Turnbull, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Usha Menon, Ian Jacobs, Rosa Legood
Jan 12, 2018
BACKGROUND: The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We evaluate the cost-effectiveness of population-based...
Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Cost-Benefit Analysis DNA Mutational Analysis Decision Support Techniques Fanconi Anemia Complementation Group N Protein Fanconi Anemia Complementation Group Proteins Female Genetic Testing Humans Incidence Mammography Middle Aged Mutation Ovarian Neoplasms RNA Helicases United Kingdom United States
Adjustment for index event bias in genome-wide association studies of subsequent events.
Frank Dudbridge, Richard J Allen, Nuala A Sheehan, A Floriaan Schmidt, James C Lee, R Gisli Jenkins, Louise V Wain, Aroon D Hingorani, Riyaz S Patel
May 13, 2019
Following numerous genome-wide association studies of disease susceptibility, there is increasing interest in genetic associations with prognosis, survival or other subsequent events. Such associations are vulnerable to index...
Ingested asbestos in filtered beer, in addition to occupational exposure, as a causative factor in oesophageal adenocarcinoma.
Oesophageal adenocarcinoma has become much more common over the past 50 years, particularly in Britain, with an unexplained male to female ratio of > 4:1. Given the use of asbestos filtration in commercial brewing and reports of...
ANCA-Associated Glomerulonephritis
Arda Göçeroğlu, Annelies E Berden, Marta Fiocco, Oliver Flossmann, Kerstin W Westman, Franco Ferrario, Gill Gaskin, Charles D Pusey, E Christiaan Hagen, Laure-Hélène Noël, Niels Rasmussen, Rüdiger Waldherr, Michael Walsh, Jan A Bruijn, David RW Jayne, Ingeborg M Bajema, European Vasculitis Society (EUVAS)
Feb 24, 2020
Relapse in ANCA-associated vasculitis (AAV) has been studied previously, but there are few studies on renal relapse in particular. Identifying patients at high risk of renal relapse may aid in optimizing clinical management. We...
Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Chronic Disease Europe Female Follow-Up Studies Glomerular Filtration Rate glomerulonephritis Humans Incidence Kidney Kidney Failure Chronic Male Middle Aged Proportional Hazards Models Recurrence Regression Analysis Risk Factors Treatment Outcome
Prostate Cancer Risk by BRCA2 Genomic Regions.
Tommy Nyberg, Debra Frost, Daniel Barrowdale, D Gareth Evans, Elizabeth Bancroft, Julian Adlard, Munaza Ahmed, Julian Barwell, Angela F Brady, Carole Brewer, Jackie Cook, Rosemarie Davidson, Alan Donaldson, Jacqueline Eason, Helen Gregory, Alex Henderson, Louise Izatt, M John Kennedy, Claire Miller, Patrick J Morrison, Alex Murray, Kai-Ren Ong, Mary Porteous, Caroline Pottinger, Mark T Rogers, Lucy Side, Katie Snape, Vishakha Tripathi, Lisa Walker, Marc Tischkowitz, Rosalind Eeles, Douglas F Easton, Antonis C Antoniou
May 07, 2020
A BRCA2 prostate cancer cluster region (PCCR) was recently proposed (c.7914 to 3') wherein pathogenic variants (PVs) are associated with higher prostate cancer (PCa) risk than PVs elsewhere in the BRCA2 gene. Using a prospective...
Serum carbon and nitrogen stable isotopes as potential biomarkers of dietary intake and their relation with incident type 2 diabetes
Pinal S Patel, Andrew JM Cooper, Tamsin C O'Connell, Gunter GC Kuhnle, Catherine K Kneale, Angela M Mulligan, Robert N Luben, Soren Brage, Kay-Tee Khaw, Nicholas J Wareham, Nita G Forouhi
Jul 11, 2014
Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes
L Tao, ECF Wilson, NJ Wareham, A Sandbaek, GEHM Rutten, T Lauritzen, K Khunti, MJ Davies, K Borch-Johnsen, SJ Griffin, RK Simmons
Aug 11, 2014
Aged Cluster Analysis Cohort Studies Combined Modality Therapy Cost-Benefit Analysis Diabetes Complications Diabetes mellitus Type 2 Female Health Care Costs Humans Incidence Male Mass Screening Middle Aged Patient Education as Topic Patient-Centered Care Quality-Adjusted Life Years Risk Factors Time Factors United Kingdom
Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies.
Preterm birth race Racial group Small for gestational age Spontaneous abortion Abortion Spontaneous Adult Age Factors Asian People Black People Body Mass Index Caribbean Region Female Humans Incidence Infant Small for Gestational Age London obesity Pregnancy premature birth Retrospective Studies Risk Factors White People Young Adult
Psychosocial aspects of closed- and open-loop insulin delivery
KD Barnard, T Wysocki, H Thabit, ML Evans, S Amiel, S Heller, A Young, R Hovorka, Angela Consortium
Aug 06, 2015
The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury
Krasimira Aleksandrova, Christina Bamia, Dagmar Drogan, Pagona Lagiou, Antonia Trichopoulou, Mazda Jenab, Veronika Fedirko, Isabelle Romieu, H Bas Bueno-De-Mesquita, Tobias Pischon, Kostas Tsilidis, Kim Overvad, Anne Tjønneland, Marie-Christine Bouton-Ruault, Laure Dossus, Antoine Racine, Rudolf Kaaks, Tilman Kühn, Christos Tsironis, Eleni-Maria Papatesta, George Saitakis, Domenico Palli, Salvatore Panico, Sara Grioni, Rosario Tumino, Paolo Vineis, Petra H Peeters, Elisabete Weiderpass, Marko Lukic, Tonje Braaten, J Ramón Quirós, Leila Luján-Barroso, María-José Sánchez, Maria-Dolores Chilarque, Eva Ardanas, Miren Dorronsoro, Lena Maria Nilsson, Malin Sund, Peter Wallström, Bodil Ohlsson, Kathryn E Bradbury, Kay-Tee Khaw, Nick Wareham, Magdalena Stepien, Talita Duarte-Salles, Nada Assi, Neil Murphy, Marc J Gunter, Elio Riboli, Heiner Boeing, Dimitrios Trichopoulos
Nov 11, 2015
European Prospective Investigation into Cancer and Nutrition Biomarkers Coffee Liver Cancer Mediation Adult Aged Biomarkers Carcinoma Hepatocellular Case-Control Studies Coffee Cohort Studies Diet Europe Female Hepatitis Humans Incidence Liver Liver Neoplasms Male Middle Aged Prospective Studies Risk Factors Statistics as Topic
Methods for conducting systematic reviews of risk factors in low- and middle-income countries.
Yulia Shenderovich, Manuel Eisner, Christopher Mikton, Frances Gardner, Jianghong Liu, Joseph Murray
Sep 29, 2016
Fish consumption and frying of fish in relation to type 2 diabetes incidence
Alice Wallin, Daniela Di Giuseppe, Nicola Orsini, Agneta Åkesson, Nita G Forouhi, Alicja Wolk
Jan 13, 2016
cohort study fish Fried foods Methyl mercury Polychlorinated biphenyls Type 2 diabetes Aged Animals Cohort Studies Cooking Diabetes mellitus Type 2 Diet Healthy Diet High-Fat Fishes Follow-Up Studies Food Contamination Humans Incidence Male Methylmercury Compounds Middle Aged Patient Compliance Polychlorinated Biphenyls Proportional Hazards Models Prospective Studies Registries seafood Shellfish Sweden Water Pollutants
Relationship of Self-Rated Health to Stroke Incidence and Mortality in Older Individuals with and without a History of Stroke
Nahal Mavaddat, Rianne van der Linde, Richard Parker, George Savva, Ann Louise Kinmonth, Carol Brayne, Jonathan Mant
Mar 14, 2016
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Peitao Wu, Denis Rybin, Lawrence F Bielak, Mary F Feitosa, Nora Franceschini, Yize Li, Yingchang Lu, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sridharan Raghavan, Lynda M Rose, Karen Schwander, Albert V Smith, Salman M Tajuddin, Dina Vojinovic, Najaf Amin, Donna K Arnett, Erwin P Bottinger, Ayse Demirkan, Jose C Florez, Mohsen Ghanbari, Tamara B Harris, Lenore J Launer, Jingmin Liu, Jun Liu, Dennis O Mook-Kanamori, Alison D Murray, Mike A Nalls, Patricia A Peyser, André G Uitterlinden, Trudy Voortman, Claude Bouchard, Daniel Chasman, Adolfo Correa, Renée de Mutsert, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Linda Kao, Sharon LR Kardia, Charles Kooperberg, Ruth JF Loos, Michael M Province, Tuomo Rankinen, Susan Redline, Paul M Ridker, Jerome I Rotter, David Siscovick, Blair H Smith, Cornelia van Duijn, Alan B Zonderman, DC Rao, James G Wilson, Josée Dupuis, James B Meigs, Ching-Ti Liu, Jason L Vassy
Jun 01, 2020
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide...
Age-related inequalities in colon cancer treatment persist over time
Louise Hayes, Lynne Forrest, Jean Adams, Mira Hidajat, Yoav Ben-Shlomo, Martin White, Linda Sharp
Jun 12, 2020
BACKGROUND: Older people experience poorer outcomes from colon cancer. We examined if treatment for colon cancer was related to age and if inequalities changed over time. METHODS: Data from the UK population-based Northern and...
Genetically raised serum bilirubin levels and lung cancer
BACKGROUND: Moderately raised serum bilirubin levels are associated with lower rates of lung cancer, particularly among smokers. It is not known whether these relationships reflect antioxidant properties or residual confounding....
Differential mobility and local variation in infection attack rate.
David J Haw, Derek AT Cummings, Justin Lessler, Henrik Salje, Jonathan M Read, Steven Riley
Feb 15, 2021
Infectious disease transmission is an inherently spatial process in which a host's home location and their social mixing patterns are important, with the mixing of infectious individuals often different to that of susceptible...
Quality of dietary fat and genetic risk of type 2 diabetes
Jordi Merino, Marta Guasch-Ferré, Christina Ellervik, Hassan S Dashti, Stephen J Sharp, Peitao Wu, Kim Overvad, Chloé Sarnowski, Mikko Kuokkanen, Rozenn N Lemaitre, Anne E Justice, Ulrika Ericson, Kim VE Braun, Yuvaraj Mahendran, Alexis C Frazier-Wood, Dianjianyi Sun, Audrey Y Chu, Toshiko Tanaka, Jian'an Luan, Jaeyoung Hong, Anne Tjønneland, Ming Ding, Annamari Lundqvist, Kenneth Mukamal, Rebecca Rohde, Christina-Alexandra Schulz, Oscar H Franco, Niels Grarup, Yii-Der Ida Chen, Lydia Bazzano, Paul W Franks, Julie E Buring, Claudia Langenberg, Ching-Ti Liu, Torben Hansen, Majken K Jensen, Katri Sääksjärvi, Bruce M Psaty, Kristin L Young, George Hindy, Camilla Helene Sandholt, Paul M Ridker, Jose M Ordovas, James B Meigs, Oluf Pedersen, Peter Kraft, Markus Perola, Kari E North, Marju Orho-Melander, Trudy Voortman, Ulla Toft, Jerome I Rotter, Lu Qi, Nita G Forouhi, Dariush Mozaffarian, Thorkild IA Sørensen, Meir J Stampfer, Satu Männistö, Elizabeth Selvin, Fumiaki Imamura, Veikko Salomaa, Frank B Hu, Nick J Wareham, Josée Dupuis, Caren E Smith, Tuomas O Kilpeläinen, Daniel I Chasman, Jose C Florez
Aug 07, 2019
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