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Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface.
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus....
Generation COVID-19 - Should the foetus be worried?
Aysha Iqbal, Charlotte Burrin, Ezra Aydin, Kathryn Beardsall, Hilary Wong, Topun Austin
Dec 11, 2020
AIM: The aim of this narrative review was to evaluate the risks, both direct and indirect, to the foetus from the COVID-19 pandemic. METHODS: Direct and indirect risks were defined as (a) vertical infection (congenital or...
Personal protective equipment and intensive care unit healthcare worker safety in the COVID-19 era (PPE-SAFE)
Alexis Tabah, Mahesh Ramanan, Kevin B Laupland, Niccolò Buetti, Andrea Cortegiani, Johannes Mellinghoff, Andrew Conway Morris, Luigi Camporota, Nathalie Zappella, Muhammed Elhadi, Pedro Povoa, Karin Amrein, Gabriela Vidal, Lennie Derde, Matteo Bassetti, Guy Francois, Nathalie Ssi Yan Kai, Jan J De Waele, PPE-SAFE contributors
Jun 18, 2020
PURPOSE: To survey healthcare workers (HCW) on availability and use of personal protective equipment (PPE) caring for COVID-19 patients in the intensive care unit (ICU). MATERIALS AND METHOD: A web-based survey distributed...
covid-19 Health care workers Intensive Care Personal protective equipment Safety Adult Africa Allied Health Personnel Asia Betacoronavirus covid-19 Coronavirus Infections Europe Eye Protective Devices Female Gloves Protective Headache Health Personnel Hot Temperature Humans Infectious Disease Transmission Patient-to-Professional Intensive Care Units Male masks Middle Aged North America Nurses Occupational health Oceania Pandemics Personal Protective Equipment Personnel Staffing and Scheduling Physicians Pneumonia Viral Respiratory Protective Devices SARS-CoV-2 South America Surgical Attire Surveys and Questionnaires Thirst
Ebola
Jonathan L Heeney
Dec 03, 2015
Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission.
Gavin K Paterson, Ewan M Harrison, Gemma GR Murray, John J Welch, James H Warland, Matthew TG Holden, Fiona JE Morgan, Xiaoliang Ba, Gerrit Koop, Simon R Harris, Duncan J Maskell, Sharon J Peacock, Michael E Herrtage, Julian Parkhill, Mark A Holmes
Feb 20, 2015
Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance.
Antonia Hufnagel, Denise S Fernandez-Twinn, Heather L Blackmore, Thomas J Ashmore, Robert A Heaton, Benjamin Jenkins, Albert Koulman, Iain P Hargreaves, Catherine E Aiken, Susan E Ozanne
Oct 01, 2021
Maternal obesity is a global problem that increases the risk of short- and long-term adverse outcomes for mother and child, many of which are linked to gestational diabetes mellitus. Effective treatments are essential to prevent...
Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.
Nick K Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael Gill, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R Bradley, Gregory J Hannon, Ian G Goodfellow, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Giles Wright, Nicholas J Matheson, Stephen Baker, Michael P Weekes
Jun 24, 2020
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus...
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Adult Asymptomatic Diseases Betacoronavirus covid-19 COVID-19 Testing Clinical Laboratory Techniques Community-Acquired Infections Contact Tracing Coronavirus Infections Disease Transmission Infectious England Family Characteristics Female Health Personnel Hospital Units Hospitals Teaching Hospitals University Humans infection control Infectious Disease Transmission Patient-to-Professional Male Mass Screening Middle Aged nasopharynx Occupational Diseases Pandemics Patient Admission Pneumonia Viral prevalence Program Evaluation Real-Time Polymerase Chain Reaction SARS-CoV-2 Symptom Assessment
Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria.
Nicaise Ndembi, Fati Murtala-Ibrahim, Monday Tola, Jibreel Jumare, Ahmad Aliyu, Peter Alabi, Charles Mensah, Alash'le Abimiku, Miguel E Quiñones-Mateu, Trevor A Crowell, Soo-Yon Rhee, Robert W Shafer, Ravindra Gupta, William Blattner, Manhattan E Charurat, Patrick Dakum
Nov 30, 2020
BACKGROUND: A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment failure...
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
Laura S Kremer, Lyuba V Bozhilova, Diana Rubalcava-Gracia, Roberta Filograna, Mamta Upadhyay, Camilla Koolmeister, Patrick F Chinnery, Nils-Göran Larsson
Jan 19, 2023
Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa
Andrew N Phillips, Loveleen Bansi-Matharu, Francois Venter, Diane Havlir, Anton Pozniak, Daniel R Kuritzkes, Annemarie Wensing, Jens D Lundgren, Deenan Pillay, John Mellors, Valentina Cambiano, Andreas Jahn, Tsitsi Apollo, Owen Mugurungi, David Ripin, Juliana Da Silva, Elliot Raizes, Nathan Ford, George K Siberry, Ravindra K Gupta, Ruanne Barnabas, Paul Revill, Jennifer Cohn, Alexandra Calmy, Silvia Bertagnolio
Mar 16, 2020
BACKGROUND: The integrase inhibitor dolutegravir is being considered in several countries in sub-Saharan Africa instead of efavirenz for people initiating antiretroviral therapy (ART) because of superior tolerability and a lower...
Adolescent Adult Africa South of the Sahara Alkynes Anti-HIV Agents Benzoxazines Cost-Benefit Analysis Cyclopropanes Female HIV Infections Heterocyclic Compounds 3-Ring Humans Infectious Disease Transmission Vertical Male Middle Aged Oxazines Piperazines Practice Guidelines as Topic Pregnancy Pregnancy Complications Pyridones Randomized Controlled Trials as Topic Young Adult
Vertical transmission of Anaplasma platys and Leishmania infantum in dogs during the first half of gestation.
Maria Stefania Latrofa, Filipe Dantas-Torres, Donato de Caprariis, Cinzia Cantacessi, Gioia Capelli, Riccardo Paolo Lia, Edward B Breitschwerdt, Domenico Otranto
May 09, 2016
Learning lessons from the paediatric critical care response to the SARS-CoV-2 pandemic in England and Wales
Emma Roche, Chun Lim, Meelad Sayma, Annakan Navaratnam, Peter J Davis, Padmanabhan Ramnarayan, James Fraser, Simon Kenny, NHS England & NHS Improvement Paediatric Critical Care Society (PCCS)
Aug 26, 2021
OBJECTIVES: To explore the experiences of clinical leads in paediatric critical care units (PCCUs) in England and Wales during the reorganisation of services in the initial surge of the SARS-CoV-2 pandemic and to learn lessons...
Health Services Research qualitative research covid-19 Child Critical Care Cross Infection England Hospital Planning Humans Infectious Disease Transmission Patient-to-Professional Intensive Care Units Interdisciplinary Communication leadership Organizational Innovation Pandemics Patient Care Team Personal protective equipment qualitative research SARS-CoV-2 Staff Development Wales