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Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude.
Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta
Jun 24, 2019
TNF is a pro-inflammatory cytokine produced by both lymphoid and non-lymphoid cells. As a consequence of the widespread expression of its receptors (TNFR1 and 2), TNF plays a role in many important biological processes. In the...
Estimating age-stratified influenza-associated invasive pneumococcal disease in England
Chiara Chiavenna, Anne M Presanis, Andre Charlett, Simon de Lusignan, Shamez Ladhani, Richard G Pebody, Daniela De Angelis
Aug 09, 2019
BACKGROUND: Measures of the contribution of influenza to Streptococcus pneumoniae infections, both in the seasonal and pandemic setting, are needed to predict the burden of secondary bacterial infections in future pandemics to...
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Phil Palmer, Joanne Marie M Del Rosario, Kelly AS da Costa, George W Carnell, Chloe Q Huang, Jonathan L Heeney, Nigel J Temperton, David A Wells
Mar 30, 2022
The emergence of COVID-19 has emphasised that biological assay data must be analysed quickly to develop safe, effective and timely vaccines/therapeutics. For viruses such as SARS-CoV-2, the primary way of measuring immune...
ELLA SARS-C0V-2 Biological Assay Data analysis dose-response Influenza pseudotype neutralization pseudovirus Antibodies Neutralizing Antibodies Viral covid-19 Data Interpretation Statistical Dose-Response Relationship Drug Humans Immunoassay Influenza A virus Influenza Human Quality Control SARS-CoV-2 Software
Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display.
Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George W Carnell, Nigel Temperton, Othmar G Engelhardt, Simon E Hufton
Aug 16, 2022
Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and wider...
Amino Acid Sequence Animals Antibodies Neutralizing Antibodies Viral Binding Sites Birds Epitopes Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H7N9 Subtype Influenza in Birds Influenza Human Models Molecular Peptide Library Protein Binding Protein Conformation Protein Interaction Domains and Motifs Saccharomyces cerevisiae Single-Domain Antibodies
High turnover drives prolonged persistence of influenza in managed pig herds.
Virginia E Pitzer, Ricardo Aguas, Steven Riley, Willie LA Loeffen, James LN Wood, Bryan T Grenfell
Aug 26, 2016
Improving pandemic influenza risk assessment.
Colin A Russell, Peter M Kasson, Ruben O Donis, Steven Riley, John Dunbar, Andrew Rambaut, Jason Asher, Stephen Burke, C Todd Davis, Rebecca J Garten, Sandrasegaram Gnanakaran, Simon I Hay, Sander Herfst, Nicola S Lewis, James O Lloyd-Smith, Catherine A Macken, Sebastian Maurer-Stroh, Elizabeth Neuhaus, Colin R Parrish, Kim M Pepin, Samuel S Shepard, David L Smith, David L Suarez, Susan C Trock, Marc-Alain Widdowson, Dylan B George, Marc Lipsitch, Jesse D Bloom
Jun 03, 2015
Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong Province, China, 2013.
Changwen Ke, Jing Lu, Jie Wu, Dawei Guan, Lirong Zou, Tie Song, Lina Yi, Xianqiao Zeng, Lijun Liang, Hanzhong Ni, Min Kang, Xin Zhang, Haojie Zhong, Jianfeng He, Jinyan Lin, Derek Smith, David Burke, Ron AM Fouchier, Marion Koopmans, Yonghui Zhang
Nov 13, 2014
Adolescent Adult Aged Animals China Environmental Monitoring Female Genome Viral Geography Medical Hemagglutinin Glycoproteins Influenza Virus High-Throughput Nucleotide Sequencing Humans Influenza A virus H7N9 Subtype Influenza in Birds Influenza Human Male Middle Aged Neuraminidase Phylogeny Phylogeography Poultry Public Health Surveillance Reassortant Viruses Viral Proteins Young Adult
Asynchrony between virus diversity and antibody selection limits influenza virus evolution.
Dylan H Morris, Velislava N Petrova, Fernando W Rossine, Edyth Parker, Bryan T Grenfell, Richard A Neher, Simon A Levin, Colin A Russell
Dec 22, 2020
Influenza virus antibody-mediated selection cross scale evolutionary dynamics evolutionary biology infectious disease microbiology Virus Antibodies Neutralizing Antibodies Viral Biological Evolution genetic variation Humans Influenza A virus H3N2 Subtype Influenza A virus Influenza Human Models Statistical selection Genetic Virion
The impact of climate and antigenic evolution on seasonal influenza virus epidemics in Australia.
Although seasonal influenza viruses circulate globally, prevention and treatment occur at the level of regions, cities, and communities. At these scales, the timing, duration and magnitude of epidemics vary substantially, but...
Characterizing Emerging Canine H3 Influenza Viruses.
Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L DeDiego, Brian R Wasik, Benjamin L Miller, Carole Henry, Patrick C Wilson, Mark Y Sangster, John J Treanor, David J Topham, Lauren Byrd-Leotis, David A Steinhauer, Richard D Cummings, Jasmina M Luczo, Stephen M Tompkins, Kaori Sakamoto, Cheryl A Jones, John Steel, Anice C Lowen, Shamika Danzy, Hui Tao, Ashley L Fink, Sabra L Klein, Nicholas Wohlgemuth, Katherine J Fenstermacher, Farah El Najjar, Andrew Pekosz, Lauren Sauer, Mitra K Lewis, Kathryn Shaw-Saliba, Richard E Rothman, Zhen-Ying Liu, Kuan-Fu Chen, Colin R Parrish, Ian EH Voorhees, Yoshihiro Kawaoka, Gabriele Neumann, Shiho Chiba, Shufang Fan, Masato Hatta, Huihui Kong, Gongxun Zhong, Guojun Wang, Melissa B Uccellini, Adolfo García-Sastre, Daniel R Perez, Lucas M Ferreri, Sander Herfst, Mathilde Richard, Ron Fouchier, David Burke, David Pattinson, Derek J Smith, Victoria Meliopoulos, Pamela Freiden, Brandi Livingston, Bridgett Sharp, Sean Cherry, Juan Carlos Dib, Guohua Yang, Charles J Russell, Subrata Barman, Richard J Webby, Scott Krauss, Angela Danner, Karlie Woodard, Malik Peiris, RAPM Perera, MCW Chan, Elena A Govorkova, Bindumadhav M Marathe, Philippe NQ Pascua, Gavin Smith, Yao-Tsun Li, Paul G Thomas, Stacey Schultz-Cherry
Jun 12, 2020
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3...
Inferring Transmission Bottleneck Size from Viral Sequence Data Using a Novel Haplotype Reconstruction Method.
Serological evidence for non-lethal exposures of Mongolian wild birds to highly pathogenic avian influenza H5N1 virus.
Martin Gilbert, Björn F Koel, Theo M Bestebroer, Nicola S Lewis, Derek J Smith, Ron AM Fouchier
Jun 03, 2015
Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.
Ellen Fragaszy, David A Ishola, Ian H Brown, Joanne Enstone, Jonathan S Nguyen-Van-Tam, Robin Simons, Alexander W Tucker, Barbara Wieland, Susanna M Williamson, Andrew C Hayward, Flu Watch Group, James LN Wood, Combating Swine Influenza (COSI) Consortium
Feb 12, 2016
Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013-2014.
Gavin JD Smith, Ruben O Donis, World Health Organization/World Organisation for Animal Health/Food and Agriculture Organization (WHO/OIE/FAO) H5 Evolution Working Group
Jun 24, 2015
H5 subtype clade nomenclature hemagglutinin highly pathogenic avian influenza molecular epidemiology phylogenetics Viral evolution Animals Biological Evolution Birds Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus Influenza in Birds Influenza Human Molecular Sequence Data Phylogeny Poultry Diseases
Fitness Inference from Short-Read Data
Christopher JR Illingworth
Jul 30, 2015
fitness landscape Influenza Linkage Disequilibrium selection within-host evolution Adaptation Physiological Alleles Animals Biological Evolution evolution Molecular Ferrets Genetic Fitness Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H5N1 Subtype Influenza Human Linkage Disequilibrium Models Genetic Orthomyxoviridae Infections Reassortant Viruses selection Genetic
Single-Cell Virus Sequencing of Influenza Infections That Trigger Innate Immunity.
Alistair B Russell, Elizaveta Elshina, Jacob R Kowalsky, Aartjan JW Te Velthuis, Jesse D Bloom
May 03, 2019
Influenza virus-infected cells vary widely in their expression of viral genes and only occasionally activate innate immunity. Here, we develop a new method to assess how the genetic variation in viral populations contributes to...
The influenza virus RNA polymerase as an innate immune agonist and antagonist.
An epidemiological overview of the equine influenza epidemic in Great Britain during 2019.
Construction of the influenza A virus transmission tree in a college-based population
BACKGROUND: Co-infection of different influenza A viruses is known to occur but how viruses interact within co-infection remains unknown. An outbreak in a college campus during the 2009 pandemic involved two subtypes of...
Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity.
Matthew L Turnbull, Helen M Wise, Marlynne Q Nicol, Nikki Smith, Rebecca L Dunfee, Philippa M Beard, Brett W Jagger, Yvonne Ligertwood, Gareth R Hardisty, Haixia Xiao, Donald J Benton, Alice M Coburn, Joao A Paulo, Steven P Gygi, John W McCauley, Jeffery K Taubenberger, Samantha J Lycett, Michael P Weekes, Bernadette M Dutia, Paul Digard
Oct 06, 2016
A549 Cells Alleles Animals Birds Cell Line Cell Line Tumor Dogs HEK293 Cells Host Specificity Humans Influenza A virus H1N1 Subtype Influenza A virus H3N2 Subtype Influenza in Birds Influenza Human Madin Darby Canine Kidney Cells Mammals Mice Mice Inbred BALB C Orthomyxoviridae Infections Phylogeny Reassortant Viruses Viral Proteins Virulence Virus Replication
IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models.
Jessica L Forbester, Mathew Clement, Dannielle Wellington, Amy Yeung, Sandra Dimonte, Morgan Marsden, Lucy Chapman, Eve L Coomber, Charlotte Tolley, Emily Lees, Christine Hale, Simon Clare, Irina Udalova, Tao Dong, Gordon Dougan, Ian R Humphreys
Mar 04, 2020
IRF5 Dendritic Cells iPSCs Inflammation Influenza Adaptive Immunity Animals Disease Models Animal Host-Pathogen Interactions Humans Immunity Innate Induced Pluripotent Stem Cells Influenza A virus Influenza Human Interferon Regulatory Factors Interferon Type I Lung MACROPHAGES Mice Orthomyxoviridae Infections Virus Replication
Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus.
Björn F Koel, David F Burke, Stefan van der Vliet, Theo M Bestebroer, Guus F Rimmelzwaan, Albert DME Osterhaus, Derek J Smith, Ron AM Fouchier
May 13, 2019
We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative...
Antigenic Maps of Influenza A(H3N2) Produced With Human Antisera Obtained After Primary Infection.
Judith M Fonville, Pieter LA Fraaij, Gerrie de Mutsert, Samuel H Wilks, Ruud van Beek, Ron AM Fouchier, Guus F Rimmelzwaan
Jul 02, 2015
Antigenic variation of clade 2.1 H5N1 virus is determined by a few amino acid substitutions immediately adjacent to the receptor binding site.
Björn F Koel, Stefan van der Vliet, David F Burke, Theo M Bestebroer, Eny E Bharoto, I Wayan W Yasa, Inna Herliana, Brigitta M Laksono, Kemin Xu, Eugene Skepner, Colin A Russell, Guus F Rimmelzwaan, Daniel R Perez, Albert DME Osterhaus, Derek J Smith, Teguh Y Prajitno, Ron AM Fouchier
Mar 16, 2015
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