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Results: 311
Closed-loop insulin delivery in suboptimally controlled type 1 diabetes
Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Yue Ruan, Judy Sibayan, Craig Kollman, Peiyao Cheng, Roy W Beck, Carlo L Acerini, Mark L Evans, David B Dunger, Daniela Elleri, Fiona Campbell, Richard M Bergenstal, Amy Criego, Viral N Shah, Lalantha Leelarathna, Roman Hovorka, APCam11 Consortium
Sep 08, 2018
BACKGROUND: The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump...
Rapid model exploration for complex hierarchical data
We consider situations, which are common in medical statistics, where we have a number of sets of response data, from different individuals, say, potentially under different conditions. A parametric model is defined for each set...
Bayesian hierarchical models Markov Chain Monte Carlo Insulin Pharmacokinetics VARIABLE SELECTION Computer Simulation Data Interpretation Statistical Diabetes mellitus Type 1 Female Humans Insulin Aspart Models Biological Monte Carlo Method Pregnancy Pregnancy Complications Reproducibility of Results
Participants' Experiences of, and Views About, Daytime Use of a Day-and-Night Hybrid Closed-Loop System in Real Life Settings
Julia Lawton, Maxine Blackburn, David Rankin, Janet M Allen, Fiona M Campbell, Lalantha Leelarathna, Martin Tauschmann, Hood Thabit, Malgorzata E Wilinska, Daniela Elleri, Roman Hovorka
Feb 07, 2019
OBJECTIVE: To explore individuals' experiences of daytime use of a day-and-night hybrid closed-loop system, their information and support needs, and their views about how future systems could be improved. RESEARCH DESIGN AND...
Artificial Pancreas Closed-loop system Medical device qualitative research type 1 diabetes User Experience Adolescent Adult Blood Glucose Blood Glucose Self-Monitoring Diabetes mellitus Type 1 Female Humans Hypoglycemic Agents Insulin Insulin Infusion Systems Longitudinal Studies Male Middle Aged Parents Patient Acceptance of Health Care qualitative research Time Factors Young Adult
Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.
Daniel J Fazakerley, Annabel Y Minard, James R Krycer, Kristen C Thomas, Jacqueline Stöckli, Dylan J Harney, James G Burchfield, Ghassan J Maghzal, Stuart T Caldwell, Richard C Hartley, Roland Stocker, Michael P Murphy, David E James
Jun 28, 2018
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they...
MITOCHONDRIAL DYSFUNCTION adipocyte Adipose Tissue Hydrogen Peroxide Insulin Insulin Resistance Mitochondria Muscle Oxidative Stress superoxide ion 3T3-L1 Cells Adenylate Kinase Adipocytes Animals Electron Transport Glucose Glucose Transporter Type 4 Herbicides Hydrogen Peroxide Insulin Insulin Resistance Male Mice Mice Inbred C57BL Mitochondria Myoblasts Oxidative Phosphorylation Oxygen Consumption Paraquat Peroxiredoxins Protein Isoforms Superoxides
Day-and-Night Closed-Loop Insulin Delivery in a Broad Population of Pregnant Women With Type 1 Diabetes
Zoe A Stewart, Malgorzata E Wilinska, Sara Hartnell, Leanne K O'Neil, Gerry Rayman, Eleanor M Scott, Katharine Barnard, Conor Farrington, Roman Hovorka, Helen R Murphy
Jul 18, 2018
OBJECTIVE: Despite advances in technology, optimal glucose control remains elusive and neonatal complications remain ubiquitous in type 1 diabetes (T1D) pregnancy. Our aim was to examine the safety, efficacy, and longer-term...
Adolescent Adult Blood Glucose Circadian Rhythm Cross-Over Studies delivery Obstetric Diabetes mellitus Type 1 Female Humans Hyperinsulinism Hypoglycemia Hypoglycemic Agents Insulin Insulin Infusion Systems Middle Aged Postpartum Period Pregnancy Pregnancy Outcome Pregnancy in Diabetics Time Factors Treatment Outcome Young Adult
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren
Jan 18, 2018
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population....
Animals Blood Glucose Body Fat Distribution Body Mass Index Fasting Female Gene Expression Regulation genetic variation Genome-Wide Association Study Genotype High-Throughput Nucleotide Sequencing Humans Insulin MicroRNAs Middle Aged Polymorphism Single Nucleotide RNA Messenger RNA Small Nucleolar RNA Small Untranslated Subcutaneous Fat
Glucagon-like peptide 1 (GLP-1).
T D Müller, B Finan, S R Bloom, D D'Alessio, D J Drucker, P R Flatt, A Fritsche, F Gribble, H J Grill, J F Habener, J J Holst, W Langhans, J J Meier, M A Nauck, D Perez-Tilve, A Pocai, F Reimann, D A Sandoval, T W Schwartz, R J Seeley, K Stemmer, M Tang-Christensen, S C Woods, R D DiMarchi, M H Tschöp
Jan 03, 2020
BACKGROUND:The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of...
Saliva Samples as A Tool to Study the Effect of Meal Timing on Metabolic And Inflammatory Biomarkers
Meal timing affects metabolic regulation in humans. Most studies use blood samples for their investigations. Saliva, although easily available and non-invasive, seems to be rarely used for chrononutritional studies. In this...
Day and night closed-loop control in adults with type 1 diabetes
Yoeri M Luijf, J Hans DeVries, Koos Zwinderman, Lalantha Leelarathna, Marianna Nodale, Karen Caldwell, Kavita Kumareswaran, Daniela Elleri, Janet M Allen, Malgorzata E Wilinska, Mark L Evans, Roman Hovorka, Werner Doll, Martin Ellmerer, Julia K Mader, Eric Renard, Jerome Place, Anne Farret, Claudio Cobelli, Simone Del Favero, Chiara Dalla Man, Angelo Avogaro, Daniela Bruttomesso, Alessio Filippi, Rachele Scotton, Lalo Magni, Giordano Lanzola, Federico Di Palma, Paola Soru, Chiara Toffanin, Giuseppe De Nicolao, Sabine Arnolds, Carsten Benesch, Lutz Heinemann, AP@home Consortium
Feb 14, 2020
OBJECTIVE: To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control. RESEARCH DESIGN AND METHODS: This study was a multicenter, randomized, three-way crossover...
Feasibility of fully automated closed-loop glucose control using continuous subcutaneous glucose measurements in critical illness
Lalantha Leelarathna, Shane W English, Hood Thabit, Karen Caldwell, Janet M Allen, Kavita Kumareswaran, Malgorzata E Wilinska, Marianna Nodale, Jasdip Mangat, Mark L Evans, Rowan Burnstein, Roman Hovorka
Feb 14, 2020
INTRODUCTION: Closed-loop (CL) systems modulate insulin delivery according to glucose levels without nurse input. In a prospective randomized controlled trial, we evaluated the feasibility of an automated closed-loop approach...
Closed-loop basal insulin delivery over 36 hours in adolescents with type 1 diabetes
Daniela Elleri, Janet M Allen, Kavita Kumareswaran, Lalantha Leelarathna, Marianna Nodale, Karen Caldwell, Peiyao Cheng, Craig Kollman, Ahmad Haidar, Helen R Murphy, Malgorzata E Wilinska, Carlo L Acerini, David B Dunger, Roman Hovorka
Feb 21, 2020
OBJECTIVE: We evaluated the safety and efficacy of closed-loop basal insulin delivery during sleep and after regular meals and unannounced periods of exercise. RESEARCH DESIGN AND METHODS: Twelve adolescents with type 1 diabetes...
Brain glucose sensing, glucokinase and neural control of metabolism and islet function.
glucokinase glucose sensing glucose-stimulated insulin secretion hypoglycaemia Hypothalamus Insulin Animals Brain Diabetes mellitus Energy Metabolism Feedback Physiological Glucokinase Glucose Humans Hypoglycemia Insulin Insulin Secretion Islets of Langerhans Models Neurological Nerve Tissue Proteins Neuroglia Neurons obesity Organ Specificity
Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.
Laura R Pearce, Ray Joe, Michael E Doche, Hsiao-Wen Su, Julia M Keogh, Elana Henning, Lawrence S Argetsinger, Elena G Bochukova, Joel M Cline, Sumedha Garg, Sadia Saeed, Steven Shoelson, Stephen O'Rahilly, Inês Barroso, Liangyou Rui, I Sadaf Farooqi, Christin Carter-Su
Jul 17, 2014
Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle
Jette Bork-Jensen, Camilla Scheele, Daniel V Christophersen, Emma Nilsson, Martin Friedrichsen, Denise S Fernandez-Twinn, Louise G Grunnet, Thomas Litman, Kim Holmstrøm, Birgitte Vind, Kurt Højlund, Henning Beck-Nielsen, Jørgen Wojtaszewski, Susan E Ozanne, Bente K Pedersen, Pernille Poulsen, Allan Vaag
Mar 19, 2015
Psychosocial aspects of closed- and open-loop insulin delivery
KD Barnard, T Wysocki, H Thabit, ML Evans, S Amiel, S Heller, A Young, R Hovorka, Angela Consortium
Aug 06, 2015
Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment.
Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juul
Nov 20, 2015
Absorptiometry Photon Adiposity Body composition Body Height Child Child Preschool Female genetic variation Genotype Glucose Human Growth Hormone Humans Infant Newborn Infant Small for Gestational Age Insulin Insulin Resistance Insulin-Like Growth Factor I Insulin-Secreting Cells Male Pancreatic Function Tests Recombinant Proteins Treatment Outcome
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
Alice E Adriaenssens, Berit Svendsen, Brian YH Lam, Giles SH Yeo, Jens J Holst, Frank Reimann, Fiona M Gribble
Jun 29, 2016
Alpha cells Beta cells Delta cells Ghrelin Glucagon Insulin RNA sequencing Somatostatin Animals Calcium Ghrelin Glucagon Glucagon-Secreting Cells Insulin Insulin-Secreting Cells Islets of Langerhans Male Mice Mice Inbred C57BL Mice Transgenic Reverse Transcriptase Polymerase Chain Reaction Somatostatin-Secreting Cells Transcriptome
Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange.
David Church, Luís Cardoso, Sonia Bradbury, Catriona Clarke, Anna Stears, Anna Dover, David Halsall, Robert Semple
Oct 24, 2016
Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight.
Christine B Jensen, Malgorzata S Martin-Gronert, Heidi Storgaard, Sten Madsbad, Allan Vaag, Susan E Ozanne
Aug 12, 2020
BACKGROUND: Low birth weight (LBW) is associated with increased future risk of insulin resistance and type 2 diabetes mellitus. The underlying molecular mechanisms remain poorly understood. We have previously shown that young...
Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee
Harry A. Smith, Aaron Hengist, Joel Thomas, Jean Philippe Walhin, Philippa Heath, Oliver Perkin, Yung Chih Chen, Javier T. Gonzalez, James A. Betts
Nov 28, 2020
Morning coffee is a common remedy following disrupted sleep, yet each factor can independently impair glucose tolerance and insulin sensitivity in healthy adults. Remarkably, the combined effects of sleep fragmentation and...
Modification of a Constitutive to Glucose-Responsive Liver-Specific Promoter Resulted in Increased Efficacy of Adeno-Associated Virus Serotype 8-Insulin Gene Therapy of Diabetic Mice.
We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to...
adeno-associated virus serotype 8 (AAV8) albumin enhancer (3′iALB) diabetes gene therapy glucose responsive element (GlRE) liver-specific glucose-responsive promoter long-term basal insulin expression Animals Dependovirus Diabetes mellitus Experimental Disease Models Animal Gene Expression Genetic Therapy Genetic Vectors Glucose Hepatocytes Humans Insulin Mice Promoter Regions Genetic Transgenes
Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
Eero A Haapala, Petri Wiklund, Niina Lintu, Tuomo Tompuri, Juuso Väistö, Taija Finni, Ina M Tarkka, Titta Kemppainen, Alan R Barker, Ulf Ekelund, Soren Brage, Timo A Lakka
Dec 03, 2019
Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion solution for liver donation after cardiac death in a pig model.
Tatsuya Shonaka, Naoto Matsuno, Hiromichi Obara, Ryo Yoshikawa, Yuji Nishikawa, Yo Ishihara, Hiroki Bochimoto, Mikako Gochi, Masahide Otani, Hiroyuki Kanazawa, Hiroshi Azuma, Hiromi Sakai, Hiroyuki Furukawa
Dec 11, 2019
The recent clinical application of perfusion technology for the machine preservation of donation after cardiac death (DCD) grafts has some advantages. Oxygenation has been proposed for the preservation of DCD liver grafts. The...
Adenosine allopurinol Animals Aspartate Aminotransferases Female Glutathione Hemoglobins Hepatic Artery Humans Hydrogen-Ion Concentration Insulin Lactic Acid Liver Liver Transplantation Mitochondria Models Animal Organ Preservation Organ Preservation Solutions Oxygen Oxygen Consumption Raffinose Swine Temperature
Genetic aetiology of glycaemic traits
Glycaemic traits such as fasting and post-challenge glucose and insulin measures, as well as glycated haemoglobin (HbA1c), are used to diagnose and monitor diabetes. These traits are risk factors for cardiovascular disease even...
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