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Adipose tissue responses to breaking sitting in men and women with central adiposity
Purpose Breaking prolonged sitting reduces postprandial glucose and insulin concentrations and influences skeletal muscle molecular signaling pathways, but it is unknown whether breaking sitting also affects adipose tissue....
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q Doe
Aug 24, 2022
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints. We...
Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance.
Weiyu Chen, Sergey Tumanov, Daniel J Fazakerley, James Cantley, David E James, Louise L Dunn, Taqi Shaik, Cacang Suarna, Roland Stocker
Nov 05, 2021
BACKGROUND & AIMS: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes...
Mechanistic and Physiological Studies of the Insulin-Dependent Regulation of FOXA2
Jessica Jean Howell
Jan 01, 0001
The Forkhead box A2 transcription factor (Foxa2/HNF-3β) has been shown to be a key regulator of genes involved in the maintenance of glucose and lipid homeostasis in the liver, and is constitutively inactivated in several...
Published by: Rockefeller University
Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity.
Pauline Morigny, Marianne Houssier, Aline Mairal, Claire Ghilain, Etienne Mouisel, Fadila Benhamed, Bernard Masri, Emeline Recazens, Pierre-Damien Denechaud, Geneviève Tavernier, Sylvie Caspar-Bauguil, Sam Virtue, Veronika Sramkova, Laurent Monbrun, Anne Mazars, Madjid Zanoun, Sandra Guilmeau, Valentin Barquissau, Diane Beuzelin, Sophie Bonnel, Marie Marques, Boris Monge-Roffarello, Corinne Lefort, Barbara Fielding, Thierry Sulpice, Arne Astrup, Bernard Payrastre, Justine Bertrand-Michel, Emmanuelle Meugnier, Laetitia Ligat, Frédéric Lopez, Hervé Guillou, Charlotte Ling, Cecilia Holm, Remi Rabasa-Lhoret, Wim HM Saris, Vladimir Stich, Peter Arner, Mikael Rydén, Cedric Moro, Nathalie Viguerie, Matthew Harms, Stefan Hallén, Antonio Vidal-Puig, Hubert Vidal, Catherine Postic, Dominique Langin
Nov 16, 2020
Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin action via the glucose-responsive...
ChREBP ELOVL Fatty Acid Elongase 6 ELOVL6 Expression Hormone-sensitive Lipase Insulin Signaling Adipocytes Adipose Tissue Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Biomarkers Fatty Acid Elongases Gene Expression Glucose Insulin Insulin Resistance Membrane Fluidity Mice Mice Transgenic Protein Interaction Mapping Protein Interaction Maps Signal Transduction Sterol Esterase
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q Doe
Sep 24, 2022
Insulin Signaling Intermediate neural progenitor Neuroblast quiescence Single cell RNA-sequencing Temporal transcription factor Animals Cell Lineage Drosophila Drosophila Proteins Drosophila melanogaster Gene Expression Gene Expression Regulation Developmental Larva Neural Stem Cells Sequence Analysis RNA
Adipose tissue responses to breaking sitting in men and women with central adiposity
Purpose Breaking prolonged sitting reduces postprandial glucose and insulin concentrations and influences skeletal muscle molecular signaling pathways, but it is unknown whether breaking sitting also affects adipose tissue....