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rhIGF-1/rhIGFBP-3 in Preterm Infants
David Ley, Boubou Hallberg, Ingrid Hansen-Pupp, Carlo Dani, Luca A Ramenghi, Neil Marlow, Kathryn Beardsall, Faizah Bhatti, David Dunger, Jason D Higginson, Ajit Mahaveer, Olachi J Mezu-Ndubuisi, Peter Reynolds, Carmen Giannantonio, Mirjam van Weissenbruch, Norman Barton, Adina Tocoian, Mohamed Hamdani, Emily Jochim, Alexandra Mangili, Jou-Ku Chung, Mark A Turner, Lois EH Smith, Ann Hellström, study team
Feb 21, 2020
OBJECTIVE: To investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy of prematurity (ROP) and other complications of prematurity among...
bronchopulmonary dysplasia intraventricular hemorrhage Neonatology retinopathy of prematurity Bronchopulmonary Dysplasia cerebral hemorrhage Female Gestational Age Humans Infant Extremely Premature Infant Newborn Infant Premature Infusions Intravenous Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Male Recombinant Proteins Retinopathy of Prematurity Severity of Illness Index Treatment Outcome
Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA.
Mathilde Gersel Wegmann, Rikke Beck Jensen, Ajay Thankamony, Jan Frystyk, Edna Roche, Hilary Hoey, Jeremy Kirk, Guftar Shaikh, Sten-A Ivarsson, Olle Söder, David B Dunger, Anders Juul
Nov 19, 2019
BACKGROUND: Some children born small for gestational age (SGA) experience supra-physiological insulin-like growth factor-I (IGF-I) concentrations during GH treatment. However, measurements of total IGF-I concentrations may not...