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The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation.
Blood vessels in the body are lined with endothelial cells which have vital roles in numerous physiological and pathological processes. Collagens are major constituents of the extracellular matrix, and many adherent cells...
The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen.
Jean-Daniel Malcor, Daniel Bax, Samir W Hamaia, Natalia Davidenko, Serena M Best, Ruth E Cameron, Richard W Farndale, Dominique Bihan
Jan 22, 2016
Biomimetic material Cell Adhesion Cell spreading HT1080 Photoreactive triple-helical peptide Rugli Binding Sites Cell Adhesion Cell Line Tumor Collagen Type I Diazomethane Ethyldimethylaminopropyl Carbodiimide Humans Integrin alpha1beta1 Integrin alpha2beta1 Peptides Protein Binding Succinimides Tissue Scaffolds