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MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation.
Joanna-Marie Howes, Nicholas Pugh, Samir W Hamaia, Stephanie M Jung, Vera Knäuper, Jean-Daniel Malcor, Richard W Farndale
Apr 26, 2018
BACKGROUND: Acute thrombotic syndromes lead to atherosclerotic plaque rupture with subsequent thrombus formation, myocardial infarction and stroke. Following rupture, flowing blood is exposed to plaque components, including...