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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig
Jul 01, 2021
OBJECTIVE: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
inflammatory bowel disease Interleukins Mucosal immunology Adolescent Adult Aged Aged 80 and over Autocrine Communication Cells Cultured Drug Resistance Female Gene Expression Gene Expression Regulation Gene Regulatory Networks Homeostasis Humans Inflammatory Bowel Diseases Interleukin-10 Interleukin-1alpha Interleukin-1beta Interleukin-23 Subunit p19 Lipopolysaccharides Male Middle Aged Monocytes Paracrine Communication Receptors Interleukin-10 Signal Transduction Transcriptome Tumor Necrosis Factor-alpha Young Adult