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A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Cora Olpe, Doran Khamis, Maria Chukanova, Nefeli Skoufou-Papoutsaki, Richard Kemp, Kate Marks, Cerys Tatton, Cecilia Lindskog, Anna Nicholson, Roxanne Brunton-Sim, Shalini Malhotra, Rogier Ten Hoopen, Rachael Stanley, Douglas J Winton, Edward Morrissey
Apr 16, 2021
BACKGROUND & AIMS: Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation....
Colorectal Cancer Initiation crypt fission crypt fusion Intestinal Crypt Adolescent Adult Age Factors Aged Aged 80 and over Cell Proliferation Cell Transformation Neoplastic Colonic Polyps Colorectal Neoplasms Diffusion Epithelial Cells Female Histone Demethylases Humans Intestinal Mucosa Male Middle Aged Models Biological Mutation Neoplastic Stem Cells Proto-Oncogene Proteins p21(ras) Young Adult