Search
Results: 7
Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome.
Wentao Shi, Andrea Massaia, Sandra Louzada, Juliet Handsaker, William Chow, Shane McCarthy, Joanna Collins, Pille Hallast, Kerstin Howe, Deanna M Church, Fengtang Yang, Yali Xue, Chris Tyler-Smith
Nov 26, 2019
BACKGROUND: Large palindromes (inverted repeats) make up substantial proportions of mammalian sex chromosomes, often contain genes, and have high rates of structural variation arising via ectopic recombination. As a result, they...
Coarse-Grained Simulations Complemented by Atomistic Molecular Dynamics Provide New Insights into Folding and Unfolding of Human Telomeric G-Quadruplexes.
Petr Stadlbauer, Liuba Mazzanti, Tristan Cragnolini, David J Wales, Philippe Derreumaux, Samuela Pasquali, Jiří Šponer
Feb 15, 2019
G-quadruplexes are the most important noncanonical DNA architectures. Many quadruplex-forming sequences, including the human telomeric sequence d(GGGTTA)n, have been investigated due to their implications in cancer and other...
Short inverted repeats contribute to localized mutability in human somatic cells.
Xueqing Zou, Sandro Morganella, Dominik Glodzik, Helen Davies, Yilin Li, Michael R Stratton, Serena Nik-Zainal
Sep 05, 2018
Selected repetitive sequences termed short inverted repeats (SIRs) have the propensity to form secondary DNA structures called hairpins. SIRs comprise palindromic arm sequences separated by short spacer sequences that form the...
Protein-directed ribosomal frameshifting temporally regulates gene expression
Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.
Daniel Duzdevich, Jinliang Li, Jhoon Whang, Hirohide Takahashi, Kunio Takeyasu, David TF Dryden, A Jennifer Morton, J Michael Edwardson
Feb 13, 2020
BACKGROUND: In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene....
Animals DNA DNA Single-Stranded Exons Gene Expression Regulation Genotype Humans Huntingtin Protein Huntington Disease Inverted Repeat Sequences Mice Microscopy Atomic Force Mutation Nerve Tissue Proteins Nuclear Proteins Nucleic Acid Conformation Polymerase Chain Reaction Site-Specific DNA-Methyltransferase (Adenine-Specific) Transcription Genetic Trinucleotide Repeats