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Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.
Victoria R Pell, Ana-Mishel Spiroski, John Mulvey, Nils Burger, Ana SH Costa, Angela Logan, Anja V Gruszczyk, Tiziana Rosa, Andrew M James, Christian Frezza, Michael P Murphy, Thomas Krieg
Sep 10, 2018
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted and then restored, and underlies many disorders, notably myocardial infarction and stroke. While reperfusion of ischemic tissue is essential for...
ischemia-reperfusion injury Ischemic preconditioning Mitochondria Succinate Analysis of Variance Animals Disease Models Animal Energy Metabolism Ischemic Preconditioning Myocardial Male Metabolome Metabolomics Mice Mitochondria Myocardial Reperfusion Injury Myocardium Oxidation-Reduction Reactive Oxygen Species Succinic Acid