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Results: 74
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J Lelliott, Jacqueline K White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J Adams, Stephen P Jackson
Feb 09, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death. Cells from HGPS patients accumulate...
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
Oct 27, 2020
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional...
Animals Cell Line Cell Movement DNA Transposable Elements Epithelial Cells Gene Dosage Genes Tumor Suppressor Genetic Predisposition to Disease Humans Kaplan-Meier Estimate Male Mice Knockout Mice Transgenic Mutagenesis Insertional Mutation PTEN Phosphohydrolase Prostate Prostatic Neoplasms RNA Interference Signal Transduction
Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward)
Adrian Murray Brunt, Joanne S Haviland, Duncan A Wheatley, Mark A Sydenham, Abdulla Alhasso, David J Bloomfield, Charlie Chan, Mark Churn, Susan Cleator, Charlotte E Coles, Andrew Goodman, Adrian Harnett, Penelope Hopwood, Anna M Kirby, Cliona C Kirwan, Carolyn Morris, Zohal Nabi, Elinor Sawyer, Navita Somaiah, Liba Stones, Isabel Syndikus, Judith M Bliss, John R Yarnold, FAST-Forward Trial Management Group
May 26, 2020
BACKGROUND: We aimed to identify a five-fraction schedule of adjuvant radiotherapy (radiation therapy) delivered in 1 week that is non-inferior in terms of local cancer control and is as safe as an international standard...
Adult Aged Aged 80 and over Breast Neoplasms Female Follow-Up Studies Humans Kaplan-Meier Estimate Mastectomy Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Recurrence Local Neoplasm Staging Radiation Dose Hypofractionation Radiation Injuries Radiotherapy Adjuvant Risk Assessment Treatment Outcome United Kingdom
Integrative Molecular Characterization of Malignant Pleural Mesothelioma.
Julija Hmeljak, Francisco Sanchez-Vega, Katherine A Hoadley, Juliann Shih, Chip Stewart, David Heiman, Patrick Tarpey, Ludmila Danilova, Esther Drill, Ewan A Gibb, Reanne Bowlby, Rupa Kanchi, Hatice U Osmanbeyoglu, Yoshitaka Sekido, Jumpei Takeshita, Yulia Newton, Kiley Graim, Manaswi Gupta, Carl M Gay, Lixia Diao, David L Gibbs, Vesteinn Thorsson, Lisa Iype, Havish Kantheti, David T Severson, Gloria Ravegnini, Patrice Desmeules, Achim A Jungbluth, William D Travis, Sanja Dacic, Lucian R Chirieac, Françoise Galateau-Sallé, Junya Fujimoto, Aliya N Husain, Henrique C Silveira, Valerie W Rusch, Robert C Rintoul, Harvey Pass, Hedy Kindler, Marjorie G Zauderer, David J Kwiatkowski, Raphael Bueno, Anne S Tsao, Jenette Creaney, Tara Lichtenberg, Kristen Leraas, Jay Bowen, TCGA Research Network, Ina Felau, Jean Claude Zenklusen, Rehan Akbani, Andrew D Cherniack, Lauren A Byers, Michael S Noble, Jonathan A Fletcher, A Gordon Robertson, Ronglai Shen, Hiroyuki Aburatani, Bruce W Robinson, Peter Campbell, Marc Ladanyi
Dec 17, 2018
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of...
Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.
Anna L Godfrey, Peter J Campbell, Cathy MacLean, Georgina Buck, Julia Cook, Julie Temple, Bridget S Wilkins, Keith Wheatley, Jyoti Nangalia, Jacob Grinfeld, Mary Frances McMullin, Cecily Forsyth, Jean-Jacques Kiladjian, Anthony R Green, Claire N Harrison, United Kingdom Medical Research Council Primary Thrombocythemia-1 Study, United Kingdom National Cancer Research Institute Myeloproliferative Neoplasms Subgroup, French Intergroup of Myeloproliferative Neoplasms, the Australasian Leukaemia and Lymphoma Group.
Sep 29, 2018
Adult Aspirin Australia Disease Progression Dose-Response Relationship Drug Drug Administration Schedule Drug Therapy Combination Female France Humans Hydroxyurea Internationality Ireland Janus Kinase 2 Kaplan-Meier Estimate Male Middle Aged New Zealand Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Severity of Illness Index Thrombocythemia Essential Thrombosis Treatment Outcome United Kingdom
Prognostic value of automated KI67 scoring in breast cancer
Mustapha Abubakar, Nick Orr, Frances Daley, Penny Coulson, H Raza Ali, Fiona Blows, Javier Benitez, Roger Milne, Herman Brenner, Christa Stegmaier, Arto Mannermaa, Jenny Chang-Claude, Anja Rudolph, Peter Sinn, Fergus J Couch, Peter Devilee, Rob AEM Tollenaar, Caroline Seynaeve, Jonine Figueroa, Mark E Sherman, Jolanta Lissowska, Stephen Hewitt, Diana Eccles, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, Carolien HM van Deurzen, kConFab Investigators, Manjeet K Bolla, Qin Wang, Michael Jones, Minouk Schoemaker, Jelle Wesseling, Flora E van Leeuwen, Laura van 't Veer, Douglas Easton, Anthony J Swerdlow, Mitch Dowsett, Paul D Pharoah, Marjanka K Schmidt, Montserrat Garcia-Closas
May 02, 2019
BACKGROUND: The value of KI67 in breast cancer prognostication has been questioned due to concerns on the analytical validity of visual KI67 assessment and methodological limitations of published studies. Here, we investigate...
Automated KI67 Breast Cancer prognostication Visual KI67 Adult Aged Aged 80 and over Biomarkers Tumor Breast Neoplasms Female Humans Immunohistochemistry Kaplan-Meier Estimate Ki-67 Antigen Middle Aged Neoplasm Grading Neoplasm Staging Population Surveillance Prognosis Proportional Hazards Models Young Adult
Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis.
Maria Escala-Garcia, Sander Canisius, Renske Keeman, Jonathan Beesley, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Marina Bermisheva, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Federico Canzian, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Fergus J Couch, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Thilo Dörk, Alison M Dunning, Douglas F Easton, Arif B Ekici, A Heather Eliassen, Peter A Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Jürgen Geisler, Graham G Giles, Mervi Grip, Melanie Gündert, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Jaana M Hartikainen, Bernadette AM Heemskerk-Gerritsen, Antoinette Hollestelle, Reiner Hoppe, John L Hopper, David J Hunter, William Jacot, Anna Jakubowska, Esther M John, Audrey Y Jung, Rudolf Kaaks, Elza Khusnutdinova, Linetta B Koppert, Peter Kraft, Vessela N Kristensen, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Robert N Luben, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Taru A Muranen, Heli Nevanlinna, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Alpa V Patel, Paolo Peterlongo, Paul DP Pharoah, Kevin Punie, Paolo Radice, Gad Rennert, Hedy S Rennert, Atocha Romero, Rebecca Roylance, Thomas Rüdiger, Matthias Ruebner, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Minouk J Schoemaker, Christopher Scott, Melissa C Southey, Harald Surowy, Anthony J Swerdlow, Rulla M Tamimi, Lauren R Teras, Emilie Thomas, Ian Tomlinson, Melissa A Troester, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, kConFab/AOCS Investigators, Kyriaki Michailidou, Georgia Chenevix-Trench, Thomas Bachelot, Marjanka K Schmidt
Nov 25, 2021
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression...
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
Mark R Pickard, Andrew R Green, Ian O Ellis, Carlos Caldas, Vanessa L Hedge, Mirna Mourtada-Maarabouni, Gwyn T Williams
Sep 12, 2011
Adenocarcinoma Apoptosis Breast Neoplasms Cell Line Tumor Epithelial Cells Female Gene Expression Regulation Neoplastic Gene Knockdown Techniques Genetic Association Studies Humans Kaplan-Meier Estimate Neoplasm Proteins Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-bcl-2 RNA Interference RNA Small Interfering Ribosomal Proteins Tumor Stem Cell Assay Ultraviolet Rays
Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging.
Adam J Brown, Zhongzhao Teng, Patrick A Calvert, Nikil K Rajani, Orla Hennessy, Nitesh Nerlekar, Daniel R Obaid, Charis Costopoulos, Yuan Huang, Stephen P Hoole, Martin Goddard, Nick EJ West, Jonathan H Gillard, Martin R Bennett
Jun 09, 2016
Atherosclerosis Autopsy Coronary Disease Myocardial Infarction Prospective Studies Acute Coronary Syndrome Aged Angina Stable Coronary Artery Disease Coronary Vessels Disease-Free Survival Female Fibrosis Humans Kaplan-Meier Estimate Male Middle Aged Necrosis Percutaneous Coronary Intervention Plaque Atherosclerotic Predictive Value of Tests Proportional Hazards Models Prospective Studies Risk Factors Rupture Spontaneous Severity of Illness Index Stress Mechanical Time Factors Treatment Outcome Ultrasonography Interventional Vascular Calcification
A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma.
Andreas A Schnitzbauer, Carl Zuelke, Christian Graeb, Justine Rochon, Itxarone Bilbao, Patrizia Burra, Koert P de Jong, Christophe Duvoux, Norman M Kneteman, Rene Adam, Wolf O Bechstein, Thomas Becker, Susanne Beckebaum, Olivier Chazouillères, Umberto Cillo, Michele Colledan, Fred Fändrich, Jean Gugenheim, Johann P Hauss, Michael Heise, Ernest Hidalgo, Neville Jamieson, Alfred Königsrainer, Philipp E Lamby, Jan P Lerut, Heikki Mäkisalo, Raimund Margreiter, Vincenzo Mazzaferro, Ingrid Mutzbauer, Gerd Otto, Georges-Philippe Pageaux, Antonio D Pinna, Jacques Pirenne, Magnus Rizell, Giorgio Rossi, Lionel Rostaing, Andre Roy, Victor Sanchez Turrion, Jan Schmidt, Roberto I Troisi, Bart van Hoek, Umberto Valente, Philippe Wolf, Heiner Wolters, Darius F Mirza, Tim Scholz, Rudolf Steininger, Gunnar Soderdahl, Simone I Strasser, Karl-Walter Jauch, Peter Neuhaus, Hans J Schlitt, Edward K Geissler
Jun 16, 2011
Australia Canada Carcinoma Hepatocellular Disease-Free Survival Europe Humans Immunosuppressive Agents Intracellular Signaling Peptides and Proteins Kaplan-Meier Estimate Liver Neoplasms Liver Transplantation Prospective Studies Protein Serine-Threonine Kinases Recurrence Risk Factors Sirolimus TOR Serine-Threonine Kinases Time Factors Transplantation Homologous Treatment Outcome
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.
Bernard Pereira, Suet-Feung Chin, Oscar M Rueda, Hans-Kristian Moen Vollan, Elena Provenzano, Helen A Bardwell, Michelle Pugh, Linda Jones, Roslin Russell, Stephen-John Sammut, Dana WY Tsui, Bin Liu, Sarah-Jane Dawson, Jean Abraham, Helen Northen, John F Peden, Abhik Mukherjee, Gulisa Turashvili, Andrew R Green, Steve McKinney, Arusha Oloumi, Sohrab Shah, Nitzan Rosenfeld, Leigh Murphy, David R Bentley, Ian O Ellis, Arnie Purushotham, Sarah E Pinder, Anne-Lise Børresen-Dale, Helena M Earl, Paul D Pharoah, Mark T Ross, Samuel Aparicio, Carlos Caldas
Mar 02, 2016
Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.
Mohammad Asim, Charles E Massie, Folake Orafidiya, Nelma Pértega-Gomes, Anne Y Warren, Mohsen Esmaeili, Luke A Selth, Heather I Zecchini, Katarina Luko, Arham Qureshi, Ajoeb Baridi, Suraj Menon, Basetti Madhu, Carlos Escriu, Scott Lyons, Sarah L Vowler, Vincent R Zecchini, Greg Shaw, Wiebke Hessenkemper, Roslin Russell, Hisham Mohammed, Niki Stefanos, Andy G Lynch, Elena Grigorenko, Clive D'Santos, Chris Taylor, Alastair Lamb, Rouchelle Sriranjan, Jiali Yang, Rory Stark, Scott M Dehm, Paul S Rennie, Jason S Carroll, John R Griffiths, Simon Tavaré, Ian G Mills, Iain J McEwan, Aria Baniahmad, Wayne D Tilley, David E Neal
Nov 03, 2015
Aged Animals Antineoplastic Agents Biomarkers Tumor Choline Kinase Enzyme Inhibitors Gene Expression Regulation Neoplastic Humans Kaplan-Meier Estimate Male Mice Mice Inbred NOD Mice SCID Middle Aged Molecular Chaperones Molecular Targeted Therapy Neoplasm Grading Neoplasm Staging Proportional Hazards Models Prostatectomy Prostatic Neoplasms Receptors Androgen Sequence Analysis DNA Signal Transduction Xenograft Model Antitumor Assays
Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome.
Alexander Laird, Fiach C O'Mahony, Jyoti Nanda, Antony CP Riddick, Marie O'Donnell, David J Harrison, Grant D Stewart
May 14, 2020
Renal cell carcinoma (RCC) is the most deadly of urological malignancies. Metastatic disease affects one third of patients at diagnosis with a further third developing metastatic disease after extirpative surgery. Heterogeneity...
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes
KM Mohankumar, DS Currle, E White, N Boulos, J Dapper, C Eden, B Nimmervoll, R Thiruvenkatam, M Connelly, TA Kranenburg, G Neale, S Olsen, Y-D Wang, D Finkelstein, K Wright, K Gupta, DW Ellison, AO Thomas, RJ Gilbertson
Aug 09, 2017
Animals Cells Cultured Chromosome Aberrations DNA Copy Number Variations Ependymoma Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes Tumor Suppressor Genetic Predisposition to Disease HEK293 Cells Humans Kaplan-Meier Estimate Male Mice Nude Mice Transgenic Microscopy Confocal Neoplasms Experimental Neural Stem Cells Oligonucleotide Array Sequence Analysis Oncogenes Reverse Transcriptase Polymerase Chain Reaction Transfection
The Risk of Severe Infections Following Rituximab Administration in Patients With Autoimmune Kidney Diseases
Balazs Odler, Martin Windpessl, Marcell Krall, Maria Steiner, Regina Riedl, Carina Hebesberger, Martin Ursli, Emanuel Zitt, Karl Lhotta, Marlies Antlanger, Daniel Cejka, Philipp Gauckler, Martin Wiesholzer, Marcus Saemann, Alexander R Rosenkranz, Kathrin Eller, Andreas Kronbichler
Nov 22, 2021
OBJECTIVE: To characterize the incidence, type, and risk factors of severe infections (SI) in patients with autoimmune kidney diseases treated with rituximab (RTX). METHODS: We conducted a multicenter retrospective cohort study...
glomerular disease Infections lupus nephritic nephrotic Rituximab Vasculitis Adult Aged Aged 80 and over Austria Autoimmune Diseases Body Mass Index Female Humans Immunologic Factors Incidence Infections Kaplan-Meier Estimate Kidney Diseases Male Middle Aged Proportional Hazards Models Registries Retrospective Studies Risk Factors Rituximab Young Adult
Factors predicting the success of trabeculectomy bleb enhancement with needling.
BACKGROUND: Bleb needling is widely used to restore flow and lower intraocular pressure (IOP) in a failing trabeculectomy. We aimed to measure the safety and efficacy of needling in a large cohort and identify factors that were...
Glaucoma glaucoma drainage implants Intraocular Pressure medications needling SURGERY Trabeculectomy Aged Aged 80 and over Female Glaucoma Humans Intraocular Pressure Kaplan-Meier Estimate Male Medical Audit Middle Aged Needles Prognosis Proportional Hazards Models Retrospective Studies Risk Factors Surgical Stomas Tonometry Ocular Trabeculectomy Visual Acuity
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G Dawson, David A Moore, David A Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-Li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C Boutros, Shu-Dong Zhang, Dean A Fennell
Apr 01, 2021
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase...
Biomarkers Tumor Cell Transformation Neoplastic Gene Deletion Gene Expression Regulation Neoplastic Gene Silencing Humans Kaplan-Meier Estimate Mesothelioma Malignant Prognosis Protein-Arginine N-Methyltransferases Proto-Oncogene Proteins c-jun Purine-Nucleoside Phosphorylase Quinacrine Transcription Genetic
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers
Costanza Paoletti, Gaia Schiavon, Emily M Dolce, Elizabeth P Darga, T Hedley Carr, Joseph Geradts, Matthias Hoch, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Shethah Morgan, Parul Patel, Vicky Rowlands, Nitharsan Sathiyayogan, Kimberly Aung, Erika Hamilton, Manish Patel, Anne Armstrong, Komal Jhaveri, Seock-Ah Im, Nadia Iqbal, Fouziah Butt, Caroline Dive, Elizabeth A Harrington, J Carl Barrett, Richard Baird, Daniel F Hayes
Nov 16, 2018
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive metastatic breast cancers include, among others, ER loss and acquired activating mutations in the ligand-binding domain of the ER...
Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival.
Andy Evans, Yee Ting Sim, Celine Pourreyron, Alastair Thompson, Lee Jordan, Dawn Fleming, Colin Purdie, Jane Macaskill, Sarah Vinnicombe, Paul Pharoah
Oct 10, 2018
INTRODUCTION: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear...
Breast Cancer neoadjuvant chemotherapy Prognosis Shear wave elastography ULTRASOUND Adult Aged Aged 80 and over Biomarkers Breast Neoplasms Elasticity Elasticity Imaging Techniques Female Humans Kaplan-Meier Estimate Middle Aged Neoplasm Grading Neoplasm Staging Preoperative Period Prognosis Tumor Microenvironment
Outcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures.
Steven W Mes, Floris HP van Velden, Boris Peltenburg, Carel FW Peeters, Dennis E Te Beest, Mark A van de Wiel, Joost Mekke, Doriene C Mulder, Roland M Martens, Jonas A Castelijns, Frank A Pameijer, Remco de Bree, Ronald Boellaard, C René Leemans, Ruud H Brakenhoff, Pim de Graaf
Jun 04, 2021
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by a variety of quantitative features extracted from diagnostic images, termed radiomics. The aim...
Factor Analysis Head and Neck Neoplasms Magnetic Resonance Imaging Prognosis Aged Area Under Curve Biomarkers Comorbidity Disease-Free Survival Factor Analysis Statistical Female Head and Neck Neoplasms Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Recurrence Local Observer Variation Prognosis Radiometry Reproducibility of Results Retrospective Studies Squamous Cell Carcinoma of Head and Neck Treatment Outcome
The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma - a substudy of the SORAMIC trial.
Tim A Labeur, Quincy Hofsink, R Bart Takkenberg, Otto M van Delden, Ron AA Mathôt, Regina Schinner, Peter Malfertheiner, Holger Amthauer, Kerstin Schütte, Bristi Basu, Christiane Kuhl, Julia Mayerle, Jens Ricke, Heinz-Josef Klümpen
May 11, 2020
Background: Sorafenib for advanced hepatocellular carcinoma (HCC) is dose adjusted by toxicity. Preliminary studies have suggested an association between plasma concentrations of sorafenib and its main metabolite (M2) and...
hepatocellular carcinoma Pharmacokinetics Sorafenib survival toxicity Aged Antineoplastic Agents Carcinoma Hepatocellular Dose-Response Relationship Drug Drug-Related Side Effects and Adverse Reactions Female Humans Incidence Kaplan-Meier Estimate Liver Neoplasms Male Middle Aged Neoplasm Staging Prospective Studies Reference Values Severity of Illness Index Sorafenib
Multi-parametric and multi-regional histogram analysis of MRI
Chao Li, Shuo Wang, Angela Serra, Turid Torheim, Jiun-Lin Yan, Natalie R Boonzaier, Yuan Huang, Tomasz Matys, Mary A McLean, Florian Markowetz, Stephen J Price
Feb 25, 2019
OBJECTIVES: Integrating multiple imaging modalities is crucial for MRI data interpretation. The purpose of this study is to determine whether a previously proposed multi-view approach can effectively integrate the histogram...
Glioblastoma Machine Learning Magnetic Resonance Imaging Prognosis Survival Analysis Brain Brain Neoplasms Cluster Analysis Contrast Media Female Glioblastoma Humans Image Enhancement Kaplan-Meier Estimate Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Phenotype Proportional Hazards Models Reproducibility of Results Retrospective Studies
Quantifying retention during pre-antiretroviral treatment in a large urban clinic in Uganda.
Barbara Castelnuovo, Joseph Musaazi, Rachel Musomba, Rosalind Parkes Ratanshi, Agnes N Kiragga
Jun 27, 2018
BACKGROUND: Retention studies are usually focused on patients on antiretroviral treatment (ART), however in Sub-Saharan Africa many patients get lost to program (LTP) in the pre-ART care period.. We investigated the proportion...
Editor's Choice - The Implications of Non-compliance to Endovascular Aneurysm Repair Surveillance
Matthew Joe Grima, Mourad Boufi, Martin Law, Dan Jackson, Kate Stenson, Benjamin Patterson, Ian Loftus, Matt Thompson, Alan Karthikesalingam, Peter Holt
Mar 19, 2018
OBJECTIVE/BACKGROUND: Increasingly, reports show that compliance rates with endovascular aneurysm repair (EVAR) surveillance are often suboptimal. The aim of this study was to determine the safety implications of non-compliance...
abdominal aortic aneurysm Endovascular Procedures EPIDEMIOLOGY Meta-Analysis Review Stents Aortic Aneurysm Abdominal Blood Vessel Prosthesis Implantation Endovascular Procedures Humans Kaplan-Meier Estimate Odds Ratio Patient Compliance Postoperative Complications Predictive Value of Tests Risk Factors Time Factors Treatment Outcome
Blinded and unblinded sample size reestimation in crossover trials balanced for period.
The determination of the sample size required by a crossover trial typically depends on the specification of one or more variance components. Uncertainty about the value of these parameters at the design stage means that there...
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