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Results: 8
Hippocampal and insula volume in mild cognitive impairment with Lewy bodies.
Michael J Firbank, Rory Durcan, John T O'Brien, Louise M Allan, Sally Barker, Joanna Ciafone, Paul C Donaghy, Calum A Hamilton, Sarah Lawley, Gemma Roberts, John-Paul Taylor, Alan J Thomas
Mar 15, 2021
Does attentional dysfunction and thalamic atrophy predict decline in dementia with Lewy bodies?
Rosie Watson, Sean J Colloby, Andrew M Blamire, Keith A Wesnes, Josh Wood, John T O'Brien
Jan 22, 2018
INTRODUCTION: To evaluate the clinical characteristics of DLB subjects who died within 1 year of assessment compared to those who survived and investigate their patterns of in vivo regional thalamic atrophy using structural MRI....
Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome.
Anila Iqbal, Marta Baldrighi, Jennifer N Murdoch, Angeleen Fleming, Christopher J Wilkinson
Oct 26, 2020
Protein aggregates are the pathogenic hallmarks of many different neurodegenerative diseases and include the accumulation of α-synuclein, the main component of Lewy bodies found in Parkinson's disease. Aggresomes are...
Neuroinflammation in Lewy body dementia.
Dementia LEWY BODY Microglia Neuroinflammation positron emission tomography Adaptive Immunity Animals Biomarkers Cytokines Disease Models Animal Forecasting Genetic Predisposition to Disease Genome-Wide Association Study HLA-D Antigens Humans Inflammation Lewy Body Disease Microglia Positron-Emission Tomography ALPHA-SYNUCLEIN
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Jessica M Froula, Marta Castellana-Cruz, Nadia M Anabtawi, José D Camino, Serene W Chen, Drake R Thrasher, Jennifer Freire, Allen A Yazdi, Sheila Fleming, Christopher M Dobson, Janet R Kumita, Nunilo Cremades, Laura A Volpicelli-Daley
May 31, 2019
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusions composed of aggregated α-synuclein (α-syn). These inclusions are associated with behavioral and pathological PD phenotypes....
LEWY BODY Parkinson's Disease Amyloid Cytotoxicity fibril motor-behavior defect Neurodegenerative disease oligomer protein aggregation α-synuclein Amyloid Animals Behavior Animal Corpus Striatum Disease Models Animal Dopaminergic Neurons Male Mice Parkinson Disease Phenotype Protein Aggregates Protein Conformation beta-Strand ALPHA-SYNUCLEIN
A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson's disease.
Thomas B Stoker, Marta Camacho, Sophie Winder-Rhodes, Ganqiang Liu, Clemens R Scherzer, Thomas Foltynie, Roger A Barker, Caroline H Williams-Gray
Mar 16, 2020
'Under pressure'
autonomic Cognition LEWY BODY MULTISYSTEM ATROPHY Parkinson's Disease cerebral small vessel diseases Cognitive Dysfunction Humans Hypotension Orthostatic Hypoxia-Ischemia Brain Lewy Body Disease Longitudinal Studies Magnetic Resonance Imaging Mental Status Schedule Multiple System Atrophy Neuroglia Parkinson Disease Positron Emission Tomography Computed Tomography Risk Factors Statistics as Topic ALPHA-SYNUCLEIN