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A model for determining cardiac mitochondrial substrate utilisation using stable 13 C-labelled metabolites

Ross T. Lindsay, Demetris Demetriou, Dominic Manetta-Jones, James A. West, Andrew J. Murray, Julian L. Griffin

Nov 25, 2020

Abstract: Introduction: Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates...

Original Article Krebs Cycle TCA cycle Isotopomer Analysis Fluxomics Metabolic Substrate Switching Lc–ms/ms Heart

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A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites.

Ross T Lindsay, Demetris Demetriou, Dominic Manetta-Jones, James A West, Andrew J Murray, Julian L Griffin

Nov 21, 2019

Fluxomics Heart Isotopomer Analysis Krebs Cycle Lc–ms/ms Metabolic Substrate Switching TCA cycle Acetyl Coenzyme A Animals Carbon Isotopes Citric Acid Cycle Glucose Heart Male Mass Spectrometry Mitochondria Models Biological Myocardium Oxidation-Reduction Rats Rats Wistar

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A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites.

Ross T Lindsay, Demetris Demetriou, Dominic Manetta-Jones, James A West, Andrew J Murray, Julian L Griffin

Jan 03, 2020

INTRODUCTION:Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates have become...

Heart TCA cycle Krebs Cycle Lc–ms/ms Fluxomics Isotopomer Analysis Metabolic Substrate Switching

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