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Adenosine Triphosphate Animals Arthritis Juvenile Bacteriolysis Cells Cultured Crohn Disease Energy Metabolism Fatty Acid Synthase Type I Genetic Predisposition to Disease Humans Infections Inflammasomes Intracellular Signaling Peptides and Proteins Leprosy Lipid Metabolism MACROPHAGES Mice Mice Inbred C57BL Mice Knockout NADPH Oxidases Oxidation-Reduction Polymorphism Single Nucleotide Proteins risk Shock Septic

Antitubercular Agents Bacterial Proteins Drug Resistance Bacterial Humans Leprosy Machine Learning Mutation Missense Mycobacterium leprae Mycobacterium tuberculosis Rifampin Staphylococcal Infections Staphylococcus aureus Tuberculosis

Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual...

Cohn Zanvil A. Rockefeller University Scientists Leprosy MACROPHAGES Hirsch James Steinman Ralph Life Sciences

antimycobacterials emergence of resistance Leprosy prediction of mutations Tuberculosis

Hansen’s disease Mycobacterium leprae Structural bioinformatics Structure–activity relationship drug target Animals Bacterial Proteins Computer Simulation Drug Design Gene Ontology Humans Leprostatic Agents Leprosy Mycobacterium leprae

Leprosy continues to be the belligerent public health hazard for the causation of high disability and eventual morbidity cases with stable prevalence rates, even with treatment by the on-going multidrug therapy (MDT). Today...

Computer Simulation Dapsone Humans Leprostatic Agents Leprosy Mycobacterium leprae Phytochemicals

BACKGROUND: Although leprosy is recognised as a disease of poverty, there is little evidence on the specific socioeconomic factors associated with disease risk. To inform targeted strategies for disease elimination, we...

Adolescent Adult Brazil Child Child Preschool Cohort Studies Female Humans Incidence Infant Infant Newborn Leprosy Male Middle Aged Registries Risk Factors Social Determinants of Health Socioeconomic Factors Young Adult

Leprosy macrophage Mycobacteria myelin nerve damage phenolic glycolipid Zebrafish Animals Antigens Bacterial Axons Demyelinating Diseases Disease Models Animal Glycolipids Larva Leprosy MACROPHAGES Mycobacterium leprae Mycobacterium marinum Myelin Sheath Neuroglia Nitric oxide Zebrafish

BACKGROUND: Survival of Mycobacterium leprae, the causative bacteria for leprosy, in the human host is dependent to an extent on the ways in which its genome integrity is retained. DNA repair mechanisms protect bacterial DNA...

Bacterial Proteins DNA Repair DNA Bacterial Escherichia coli Gene Expression Profiling Gene Expression Regulation Bacterial Humans Leprosy Mycobacterium leprae Mycobacterium tuberculosis Oligonucleotide Array Sequence Analysis Promoter Regions Genetic Sequence Alignment Sequence Homology

Vincent Dole Arnold Beckman Leprosy Children's School Pasteur Institute

Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at ~30°C, so we sought to model...

Granuloma Leprosy Mycobacteria Zebrafish Animals Disease Models Animal Granuloma Leprosy Male Mycobacterium leprae Zebrafish

The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present...

Adolescent Adult Bacterial Proteins DNA Bacterial DNA-Directed RNA Polymerases Drug Resistance Bacterial Female Humans india Leprostatic Agents Leprosy Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium leprae Protein Binding Protein Stability Recurrence Rifampin Sequence Analysis DNA Structure-Activity Relationship Treatment Outcome Young Adult

BACKGROUND: Although leprosy is largely curable with multidrug therapy, incomplete treatment limits therapeutic effectiveness and is an important obstacle to disease control. To inform efforts to improve treatment completion...

Brazil Cohort Studies Drug Therapy Combination Ethnicity Female Geography Humans Leprostatic Agents Leprosy Male Socioeconomic Factors Treatment Adherence and Compliance

BACKGROUND: Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in...

ancient DNA Ancient Pathogen Genomics Leprosaria Mycobacterium leprae Paleomicrobiology paleopathology Pathogen Diversity Pathogen Population Dynamics Europe Genome Bacterial Humans Leprosy Mycobacterium leprae Population Dynamics

Hansen’s disease (leprosy), mainly caused by infection with Mycobacterium leprae, has accompanied humanity for thousands of years. Although currently rare in Europe, there are over 200,000 new infections annually in South East...

microbiology Mycobacterium leprae Leprosy palaeomicrobiology zoonosis One Health palaeopathology Ancient Biomolecules ancient pathogens

Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium tuberculosis and Mycobacterium leprae respectively. These diseases continue to be endemic in developing countries where the cost of new medicines...

Genetics emergence of resistance Tuberculosis Leprosy prediction of mutations antimycobacterials

Studying ancient DNA allows us to retrace the evolutionary history of human pathogens, such as Mycobacterium leprae, the main causative agent of leprosy. Leprosy is one of the oldest recorded and most stigmatizing diseases in...

DNA Bacterial Europe evolution Molecular genetic variation Genome Bacterial History Medieval Host-Pathogen Interactions Humans Leprosy Mycobacterium leprae Phylogeny Phylogeography Polymorphism Single Nucleotide

ancient DNA Ancient genomics Hepatitis B virus Infectious Diseases Leprosy parvovirus B19 Pathogen evolution pathogen genomics smallpox variola virus Middle Aged Humans Phylogeny Coinfection Mycobacterium leprae Leprosy DNA Ancient