FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.
Kia Joo Puan,
Boris San Luis,
Nurhashikin Yusof,
Dilip Kumar,
Anand Kumar Andiappan,
Wendy Lee,
Samanta Cajic,
Dragana Vuckovic,
Jing De Chan,
Tobias Döllner,
Han Wei Hou,
Yunxuan Jiang,
Chao Tian,
23andMe Research Team,
Erdmann Rapp,
Michael Poidinger,
De Yun Wang,
Nicole Soranzo,
Bernett Lee,
Olaf Rötzschke
Sep 01, 2021
Sialyl-Lewis x (sLex, CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for leukocytes to migrate out of the blood vessels. Here we show using flow cytometry that...