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Results: 1199
Tumor Suppression by a TRNA Synthetase
Maria Passarelli
Jan 01, 0001
Despite substantial progress in treatment, breast cancer remains a leading cause of cancer mortality among women. During malignant transformation, healthy mammary cells must bypass tumor suppressive checkpoints and activate...
Published by: Rockefeller University
Conditional Protein Alleles and Regulation of Bacterial Transcription: A Thesis in Two Acts
Edmund Ching Schwartz
Jan 01, 0001
The use of small molecule modulators of protein function (drugs) has gained in popularity due to the speed and precision with which they can work. Unfortunately, a small molecule with the required specificity and potency is not...
Published by: Rockefeller University
Chronic Stress Effects on Prefrontal Cortical Structure and Function
Conor Liston
Jan 01, 0001
Stressful life events have been implicated clinically in the pathogenesis of major depression, but the neural substrates that may account for this observation remain poorly understood. Attentional impairments symptomatic of...
Published by: Rockefeller University
Life on a Ball: Multi-Week Tethered Behavior in Drosophila
Jazz Weisman
Jan 01, 0001
By studying head fixed or rigidly tethered animals, neuroscientists have been able to make high-resolution neurophysiological and behavioral measurements during naturalistic tasks. Tethered paradigms have a particularly rich...
Published by: Rockefeller University
Peptidergic Signaling Controls the Dynamics of Sickness Behavior in Caenorhabditis Elegans
Javier Marquina-Solis
Jan 01, 0001
Disease is accompanied by modifications to host behavior that promote recovery and survival. The neural and molecular mechanisms that rule the switch to a sickness behavioral state are an active area of research. One established...
Published by: Rockefeller University
Haplotype-Based Association Studies: Approaches to Current Challenges
Mark A. Levenstien
Jan 01, 0001
Haplotype-based association studies have greatly aided researchers in their attempts to map genes. However, current designs of haplotype-based association studies lead to several challenges from a statistical perspective. To...
Published by: Rockefeller University
Revealing SMC5/6's Dynamic Behavior on Diverse DNA Topologies Through Single-Molecule Methods
Jeremy Tzu-Huai Chang
Jan 01, 0001
The structural maintenance of chromosomes (SMC) protein complexes serve as critical molecular motors for maintaining genome stability and ensuring faithful genome propagation. As one of the three eukaryotic SMC complexes, the...
Published by: Rockefeller University
RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma
Christoph Neumayer
Jan 01, 0001
Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer characterized by a recurrent fusion of the heat shock protein DNAJB1 and the catalytic subunit of protein kinase A (PRKACA). Due to limited efficacy of...
Published by: Rockefeller University
Single-Molecule Studies of CFTR Gating and Pharmacology
Jesper Bøegh Levring
Jan 01, 0001
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel expressed in the apical membrane of epithelial tissues. Alterations in CFTR that disrupt activity cause cystic fibrosis, a fatal disease which...
Published by: Rockefeller University
Comparative Analysis of Alternative Splicing in Homo sapiens, Mus musculus and Rattus norvegicus Transcriptomes
Bahar Taneri
Jan 01, 0001
Analyzing transcriptomes in the context of all available genome and transcript sequence data has the potential to reveal biologically meaningful insight into functional properties of genes and complexity of genomes. Alternative...
Published by: Rockefeller University
Telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
Oliver Dreesen
Jan 01, 0001
A variety of parasites persist in their host through sequential expression of variant surface antigens. Intriguingly, the genes encoding these antigens are frequently found adjacent to the telomeres. Telomeres are nucleoprotein...
Published by: Rockefeller University
Characterization of the Functional Role of the Intracellular Cholesterol Transporter StARD4 in Knockout Mice, and Investigation of Epigenetic Modulation of ApoA-I Transcription
Joshua Riegelhaupt
Jan 01, 0001
Cholesterol is crucial for mammalian survival by playing important roles, such as regulating membrane fluidity and as a precursor for the synthesis of steroid and sex hormones, bile acids, and Vitamin D. In addition, cellular...
Published by: Rockefeller University
Biophysical Characterization of Structure and Dynamics of Nuclear Pore Complex Components
Martin Kampmann
Jan 01, 0001
The Nuclear Pore Complex (NPC) mediates nucleo-cytoplasmic transport in all eukaryotes and is among the largest cellular assemblies of proteins, called nucleoporins (nups). The details of NPC architecture, dynamics, and...
nuclear pore complex Electron microscopy Nup84 complex structural biology fluorescence anisotropy polarized fluorescence microscopy Life Sciences
Published by: Rockefeller University
Recombination and Excision: DNA Repair Proteins in Prokaryotic Host-Virus Conflicts
Amer Azim Hossain
Jan 01, 0001
Bacteriophages, or simply phages, are viruses that infect bacteria. They are the most abundant biological entity on our planet and outnumber bacteria 10:1 in the ocean. In response to this threat, bacteria have evolved a diverse...
Published by: Rockefeller University
The Dual Role of OCA-B in B Cell Development and Signaling
Rachael Siegel
Jan 01, 0001
OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream...
Published by: Rockefeller University
Natural Product Biosynthesis In Uncultured Bacteria
Jeffrey Kim
Jan 01, 0001
A single gram of soil can contain thousands of unique bacterial species, only a small fraction of which is regularly cultured in the laboratory.Although the fermentation of cultured microorganisms has provided access to numerous...
uncultured bacteria soil derived DNA fragments natural product biosynthesis eDNA libraries Life Sciences
Published by: Rockefeller University
Transfer Properties of the Hair Cell-Afferent Fiber Synapse
Erica C. Keen
Jan 01, 0001
The perception of sound is initiated in the inner ear by the conversion of vibrational energy into a neural code, a transduction process achieved by the chemical synapses of hair cells in the auditory periphery. Thus, the...
Published by: Rockefeller University
Regulation of Gene Expression in Trypanosoma brucei
Tim Nicolai Siegel
Jan 01, 0001
The protozoan parasite Trypanosoma brucei is one of the most divergent well-studied eukaryotes and many discoveries of general interest have been made in T. brucei. Atypical for a eukaryote, in T. brucei genes transcribed by RNA...
Trypanosoma brucei Gene regulation trans splicing efficiency histone variants RNA pol II transcription factors Life Sciences
Published by: Rockefeller University
Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
Fang-Yuan Chang
Jan 01, 0001
Most microbial natural product discovery programs rely on the growth of bacteria in the laboratory, yet it is now well established that the vast majority of bacteria in the environment have not been cultured, particularly from...
Published by: Rockefeller University
Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
Kavita J Rangan
Jan 01, 0001
The intestinal microbiome can mediate host resistance to enteric pathogens by modulating host immunity or by directly inhibiting pathogen growth and virulence. Although the abundance and diversity of bacterial metabolites in...
Published by: Rockefeller University
Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
Daniel Blanco Melo
Jan 01, 0001
About 8 and 10 percent of the human and mouse genomes, respectively, are comprised of sequences of retroviral origin. Occasional infection of germ line can lead to integrated retroviral genomes being vertically inherited as host...
Published by: Rockefeller University
The Oncogene of Avian Sarcoma Virus UR2 and its Cellular Homologue: Structure, Sequence and Expression
Wendi S Neckameyer
Jan 01, 0001
Avian sarcoma virus UR2 is a replication-defective virus that can induce sarcomas in vivo and transforms chicken embryo fibroblasts in culture to a characteristic, extremely elongated morphology. The genome of UR2 contains a 1.2...
Published by: Rockefeller University
Information Encoding by Individual Neurons and Groups of Neurons in the Primary Visual Cortex
Daniel Salo Reich
Jan 01, 0001
How is information about visual stimuli encoded into the responses of neurons in the cerebral cortex? In this thesis, I describe the analysis of data recorded simultaneously from groups of up to eight nearby neurons in the...
Published by: Rockefeller University
Germline Genetic Determination of Cancer Outcome
Benjamin N Ostendorf
Jan 01, 0001
Immunotherapy has transformed the treatment of melanoma patients. However, despite the enormous promise of immunotherapy, a major fraction of patients with advanced melanoma still succumb to this deadly disease. In addition...
Published by: Rockefeller University
Investigating Developmental Milestones and Adult Behavior in a Mammalian Model of Fetal Alcohol Spectrum Disorder (FASD)
Mark A Nagy
Jan 01, 0001
Prenatal exposure to ethanol can result in an abundance of psychological, physical and developmental impairments that can alter the behavioral and cognitive abilities of an organism and can cause long-lasting developmental...
Fetal Alcohol Spectrum Disorder FASD Swiss Webster mice Drinking in the Dark paradigm prenatal ethanol exposure Behavior development mouse model Developmental Neuroscience Life Sciences Neuroscience and Neurobiology
Published by: Ursinus College
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