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The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion.
Rowan F van Golen, Megan J Reiniers, Gerben Marsman, Lindy K Alles, Derrick M van Rooyen, Björn Petri, Vincent A Van der Mark, Adriaan A Van Beek, Ben Meijer, Martinus A Maas, Sacha Zeerleder, Joanne Verheij, Geoffrey C Farrell, Brenda M Luken, Narci C Teoh, Thomas M van Gulik, Michael P Murphy, Michal Heger
Feb 12, 2019
OBJECTIVE AND BACKGROUND: Activation of sterile inflammation after hepatic ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with mitochondrial oxidative stress and cell death during early...
antioxidants Damage-associated molecular patterns Intravital Microscopy Liver resection Mitochondrial DNA Sterile inflammation Aged Alarmins antioxidants Cytokines DNA Mitochondrial Female HMGB1 Protein Humans Liver Male Middle Aged Mitochondria Organophosphorus Compounds Oxidative Stress Reperfusion Injury Ubiquinone