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7 T magnetic resonance imaging Parkinson's Disease Apathy Cognition Locus Coeruleus magnetization-transfer imaging Noradrenaline progressive supranuclear palsy Apathy Cognition Humans Locus Coeruleus Magnetic Resonance Imaging Parkinson Disease Parkinsonian Disorders Supranuclear Palsy Progressive

Human congenital central hypoventilation syndrome (CCHS), resulting from mutations in transcription factor PHOX2B, manifests with impaired responses to hypoxemia and hypercapnia especially during sleep. To identify brainstem...

Age of Onset Animals Disease Models Animal Homeodomain Proteins Humans Hypoventilation Infant Newborn Infant Premature Locus Coeruleus Male Mice Inbred C57BL Mice Transgenic Mutation Neurogenesis Neurons Respiration Sleep Apnea Central Tissue Culture Techniques Transcription Factors

frontotemporal dementia Locus Coeruleus neurodegeneration Noradrenalin progressive supranuclear palsy Tau Adrenergic Neurons Aged Aged 80 and over Female Humans Locus Coeruleus Male Middle Aged Phosphorylation Severity of Illness Index Supranuclear Palsy Progressive tau Proteins

Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...

basal ganglia Locus Coeruleus Substantia Nigra striosomes/matrix neurodegeneration ferritin Hepcidin Alzheimer’s disease (AD) Parkinson’s disease (PD) Down syndrome (DS)

The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour....

Locus Coeruleus Tau neurodegeneration frontotemporal dementia progressive supranuclear palsy Noradrenalin

Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. The LC can be identified in vivo using...

7T MRI Contrast-to-noise ratio Locus Coeruleus neurodegenerative disorders Probabilistic atlas Aged Aged 80 and over Female Humans Locus Coeruleus Magnetic Resonance Imaging Middle Aged

BACKGROUND: Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during...

eye tracking biomarker Brainstem cerebellum Locus Coeruleus pupillometry visual attention Attention Autism spectrum disorder Cerebellar Ataxia Eye Movements Female Humans Infant Newborn Male Saccades

The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic depletion, evidence indicates extensive LC...

Alzheimer's Disease Locus Coeruleus neuromelanin‐sensitive magnetic resonance imaging Noradrenaline Norepinephrine Systematic review

Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...

Alzheimer’s disease (AD) Down syndrome (DS) Parkinson’s disease (PD) basal ganglia ferritin Hepcidin Locus Coeruleus neurodegeneration striosomes/matrix Substantia Nigra Alzheimer Disease Brain Cation Transport Proteins Down Syndrome Ferritins Hepcidins Humans Iron Neurodegenerative Diseases Parkinson Disease Protein Aggregates

Abstract: The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour....

Research frontotemporal dementia Locus Coeruleus progressive supranuclear palsy Tau neurodegeneration Noradrenalin

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in...

Cognition Dementia Locus Coeruleus neurodegeneration Noradrenaline Cognition Cognition Disorders Humans Locus Coeruleus Norepinephrine

Abstract: The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour....

Research frontotemporal dementia Locus Coeruleus progressive supranuclear palsy Tau neurodegeneration Noradrenalin

Animals Male Rats Adaptation Psychological Compulsive Behavior Down-Regulation Locus Coeruleus Neurons Rats Sprague-Dawley RNA Messenger Tyrosine 3-Monooxygenase

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous system, may play an important role in neuropsychiatric disorders including Parkinson's disease and Alzheimer's disease. The pattern of...

aging Locus Coeruleus Magnetic Resonance Imaging neuromelanin Noradrenergic system Adolescent Adult Aged Aged 80 and over Cognition Female healthy aging Humans Locus Coeruleus Magnetic Resonance Imaging Male Melanins Middle Aged Young Adult

Parkinson’s disease atomoxetine Locus Coeruleus neuromelanin imaging Noradrenaline Adrenergic Uptake Inhibitors Aged Atomoxetine Hydrochloride Double-Blind Method Female Humans INHIBITION Psychological Locus Coeruleus Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Parkinson Disease Reaction Time