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Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients.
Sara Ruiz-Pinto, Guillermo Pita, Miguel Martín, Teresa Alonso-Gordoa, Daniel R Barnes, María R Alonso, Belén Herraez, Purificación García-Miguel, Javier Alonso, Antonio Pérez-Martínez, Antonio J Cartón, Federico Gutiérrez-Larraya, José A García-Sáenz, Javier Benítez, Douglas F Easton, Ana Patiño-García, Anna González-Neira
Jan 30, 2018
PURPOSE: Anthracyclines are widely used chemotherapeutic drugs that can cause progressive and irreversible cardiac damage and fatal heart failure. Several genetic variants associated with anthracycline-induced cardiotoxicity...
Anthracyclines Chronic cardiotoxicity ETFB Long-term cancer survivors Low-frequency variants Adult Aged Anthracyclines Breast Neoplasms Cancer Survivors Cardiotoxicity Electron-Transferring Flavoproteins Exome Female Gene Expression Regulation Neoplastic Genetic Association Studies Genetic Predisposition to Disease Heart Failure Humans Middle Aged Mitochondria