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Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
Iris E Jansen, Hui Ye, Sasja Heetveld, Marie C Lechler, Helen Michels, Renée I Seinstra, Steven J Lubbe, Valérie Drouet, Suzanne Lesage, Elisa Majounie, J Raphael Gibbs, Mike A Nalls, Mina Ryten, Juan A Botia, Jana Vandrovcova, Javier Simon-Sanchez, Melissa Castillo-Lizardo, Patrizia Rizzu, Cornelis Blauwendraat, Amit K Chouhan, Yarong Li, Puja Yogi, Najaf Amin, Cornelia M van Duijn, International Parkinson’s Disease Genetics Consortium (IPGDC), Huw R Morris, Alexis Brice, Andrew B Singleton, Della C David, Ellen A Nollen, Shushant Jain, Joshua M Shulman, Peter Heutink
Nov 13, 2017
BACKGROUND: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated...
animal model Functional screening Genomics Loss-of-function Mitochondria Parkin Parkinson’s disease rare variants whole-exome sequencing α-synuclein Adolescent Adult Animals Animals Genetically Modified Caenorhabditis elegans Case-Control Studies Cells Cultured Child Disease Models Animal Drosophila melanogaster Exome Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Humans Middle Aged Parkinson Disease RNA Interference Sequence Analysis DNA Young Adult ALPHA-SYNUCLEIN
Exploring Novel Roles for the Slitrk Protein Family
Jordyn S Karliner
Jan 01, 0001
Slitrk proteins are a family of six transmembrane proteins (Slitrk1-Slitrk6) that belong to the larger leucine-rich repeat protein family. Previous studies have linked Slitrk proteins to many neuropsychiatric disorders...
Neurogenesis Slitrk2 ventricular zone immunostaining Loss-of-function morpholino Biology Life Sciences
Published by: Ursinus College