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Results: 11
Morphological and genomic shifts in mole-rat 'queens' increase fecundity but reduce skeletal integrity.
Rachel A Johnston, Philippe Vullioud, Jack Thorley, Henry Kirveslahti, Leyao Shen, Sayan Mukherjee, Courtney M Karner, Tim Clutton-Brock, Jenny Tung
Jul 09, 2021
In some mammals and many social insects, highly cooperative societies are characterized by reproductive division of labor, in which breeders and nonbreeders become behaviorally and morphologically distinct. While differences in...
Chromosomes cooperative breeding eusociality evolutionary biology Gene Expression Gene regulation mole-rat phenotypic plasticity skeletal bone Age Factors Animals Biological Evolution Bone Development Cooperative Behavior Femur Fertility Gene Expression Regulation Genome Lumbar Vertebrae Mole Rats Sex Factors Sexual Behavior Animal Social Behavior
High correlation of temporal muscle thickness with lumbar skeletal muscle cross-sectional area in patients with brain metastases.
Johannes Leitner, Sebastian Pelster, Veronika Schöpf, Anna S Berghoff, Ramona Woitek, Ulrika Asenbaum, Karl-Heinz Nenning, Georg Widhalm, Barbara Kiesel, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Daniela Prayer, Matthias Preusser, Julia Furtner
Dec 20, 2018
OBJECTIVES: This study aimed to assess the correlation of temporal muscle thickness (TMT), measured on routine cranial magnetic resonance (MR) images, with lumbar skeletal muscles obtained on computed tomography (CT) images in...
Kinematic Behaviour of a Novel Pedicle Screw-Rod Fixation System for the Canine Lumbosacral Joint
Objective: To determine the biomechanical behaviour of a novel distraction-stabilization system, consisting of an intervertebral distraction bolt, polyaxial screws and connecting rods, in the canine lumbosacral spine.
Study...
Presynaptic control of transmission through group II muscle afferents in the midlumbar and sacral segments of the spinal cord is independent of corticospinal control.
Transmission of information from the terminals group II muscle afferents is subject to potent presynaptic modulation by both segmental group II and cutaneous afferents and by descending monoaminergic systems. Currently it is...
Afferent Pathways Electric Stimulation Excitatory Postsynaptic Potentials Inhibitory Postsynaptic Potentials Lumbar Vertebrae Motor Cortex Muscle Tonus Muscle Skeletal Neural Conduction Neural Inhibition Presynaptic Terminals Pyramidal Tracts Reflex Sacrum Spinal Cord Spinal Nerve Roots Synaptic Transmission
Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis.
Harish K Datta, Marianne K Kringen, Stephen P Tuck, Georgia Salpingidou, Ole K Olstad, Kaare M Gautvik, Simon J Cockell, Vigdis T Gautvik, Michael Prediger, Jun Jie Wu, Mark A Birch, Sjur Reppe
Mar 10, 2022
Mechanical loading exerts a profound influence on bone density and architecture, but the exact mechanism is unknown. Our study shows that expression of the neurological transcriptional factor zinc finger of the cerebellum 1...
'Sink or swim'
CL Gregson, SA Steel, KP O'Rourke, K Allan, J Ayuk, A Bhalla, G Clunie, N Crabtree, I Fogelman, A Goodby, CM Langman, S Linton, E Marriott, E McCloskey, KE Moss, T Palferman, S Panthakalam, KES Poole, MD Stone, J Turton, D Wallis, S Warburton, J Wass, EL Duncan, MA Brown, G Davey-Smith, JH Tobias
Oct 14, 2020
SUMMARY: High bone mineral density on routine dual energy X-ray absorptiometry (DXA) may indicate an underlying skeletal dysplasia. Two hundred fifty-eight individuals with unexplained high bone mass (HBM), 236 relatives (41%...
Is vigorous-intensity physical activity required for improving bone mass in adolescence? Findings from a Brazilian birth cohort.
RM Bielemann, VV Ramires, FC Wehrmeister, H Gonçalves, MCF Assunção, U Ekelund, BL Horta
Mar 11, 2019
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
Felix R Day, Brendan Bulik-Sullivan, David A Hinds, Hilary K Finucane, Joanne M Murabito, Joyce Y Tung, Ken K Ong, John RB Perry
Sep 29, 2015
Adolescent Basic Helix-Loop-Helix Transcription Factors Body Height Body Mass Index Bone Density Cardiovascular Diseases Child Cholesterol HDL Diabetes mellitus Type 2 Extracellular Matrix Proteins Female Genome-Wide Association Study Humans Insulin Lumbar Vertebrae Male Nerve Tissue Proteins Nuclear Receptor Subfamily 1 Group F Member 2 POLYCYSTIC OVARY SYNDROME Puberty Radiography Receptors G-Protein-Coupled Receptors Leptin Receptors Pituitary Hormone Repressor Proteins Retinoid X Receptor alpha Sex Factors Time Factors Triglycerides White People Young Adult
Romosozumab Enhances Vertebral Bone Structure in Women With Low Bone Density.
Kenneth ES Poole, Graham M Treece, Rose A Pearson, Andrew H Gee, Michael A Bolognese, Jacques P Brown, Stefan Goemaere, Andreas Grauer, David A Hanley, Carlos Mautalen, Chris Recknor, Yu-Ching Yang, Maria Rojeski, Cesar Libanati, Tristan Whitmarsh
Jan 05, 2022
Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.
Anna L Eriksson, John RB Perry, Andrea D Coviello, Graciela E Delgado, Luigi Ferrucci, Andrew R Hoffman, Ilpo T Huhtaniemi, M Arfan Ikram, Magnus K Karlsson, Marcus E Kleber, Gail A Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L Lunetta, Dan Mellström, Joanne M Murabito, Anna Murray, Maria Nethander, Carrie M Nielson, Inga Prokopenko, Stephen R Pye, Leslie J Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G Travison, André G Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M Zmuda, Winfried März, Eric S Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick CW Wu, Frank H de Jong, Shalender Bhasin, Douglas P Kiel, Claes Ohlsson
Jun 26, 2018
CONTEXT: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. OBJECTIVE: To investigate the genetic regulation of serum E2 and E1 in men. DESIGN, SETTING, AND PARTICIPANTS: Genome-wide association study...