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Results: 16
Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19)
Jude Moutchia, Pratik Pokharel, Aldiona Kerri, Kaodi McGaw, Shreeshti Uchai, Miriam Nji, Michael Goodman
Oct 01, 2020
Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection.
Jawaher Alsughayyir, Manu Chhabra, M Saeed Qureshi, Mekhola Mallik, Jason M Ali, Ivonne Gamper, Ellen L Moseley, Sarah Peacock, Vasilis Kosmoliaptsis, Martin J Goddard, Michelle A Linterman, Reza Motallebzadeh, Gavin J Pettigrew
Feb 12, 2019
Humoral alloimmunity is now recognized as a major determinant of transplant outcome. MHC glycoprotein is considered a typical T-dependent antigen, but the nature of the T cell alloresponse that underpins alloantibody generation...
allograft extrafollicular B cell response germinal center (GC) humoral alloimmunity Transplantation vasculopathy Adoptive Transfer Allografts Animals B-Lymphocytes DNA-Binding Proteins Disease Models Animal Disease Progression Graft Rejection Heart Transplantation Humans Isoantibodies Isoantigens Lymphocyte Count Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein T-Lymphocytes Helper-Inducer Transplantation Homologous
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Mary-Ellen Lynall, Lorinda Turner, Junaid Bhatti, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan Jones, Wayne C Drevets, Philip Cowen, Neil A Harrison, Carmine M Pariante, Linda Pointon, Menna R Clatworthy, Edward Bullmore, Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA) Consortium
Dec 11, 2019
Treatment of COVID-19 with remdesivir in the absence of humoral immunity
Matthew S Buckland, James B Galloway, Caoimhe Nic Fhogartaigh, Luke Meredith, Nicholas M Provine, Stuart Bloor, Ane Ogbe, Wioleta M Zelek, Anna Smielewska, Anna Yakovleva, Tiffeney Mann, Laura Bergamaschi, Lorinda Turner, Frederica Mescia, Erik JM Toonen, Carl-Philipp Hackstein, Hossain Delowar Akther, Vinicius Adriano Vieira, Lourdes Ceron-Gutierrez, Jimstan Periselneris, Sorena Kiani-Alikhan, Sofia Grigoriadou, Devan Vaghela, Sara E Lear, M Estée Török, William L Hamilton, Joanne Stockton, Josh Quick, Peter Nelson, Michael Hunter, Tanya I Coulter, Lisa Devlin, CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium, John R Bradley, Kenneth GC Smith, Willem H Ouwehand, Lise Estcourt, Heli Harvala, David J Roberts, Ian B Wilkinson, Nick Screaton, Nicholas Loman, Rainer Doffinger, Paul A Lyons, B Paul Morgan, Ian G Goodfellow, Paul Klenerman, Paul J Lehner, Nicholas J Matheson, James ED Thaventhiran
Oct 13, 2020
RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Ivet A Yordanova, Alba Cortés, Christian Klotz, Anja A Kühl, Markus M Heimesaat, Cinzia Cantacessi, Susanne Hartmann, Sebastian Rausch
Nov 26, 2019
Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with varying...
Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers.
Elizabeth F Wallin, Elaine C Jolly, Ondřej Suchánek, J Andrew Bradley, Marion Espéli, David RW Jayne, Michelle A Linterman, Kenneth GC Smith
Oct 07, 2014
Adolescent Adult Aged Antibodies Monoclonal Murine-Derived Antibody Formation Antigens CD19 B-Lymphocytes CD57 Antigens Cell Differentiation Cells Cultured Coculture Techniques Female Flow Cytometry Germinal Center Humans Immunologic Factors Lymph Nodes Lymphocyte Count Male Middle Aged Receptors CXCR5 Rituximab T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Tumor Necrosis Factor Receptor Superfamily Member 7 Young Adult
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...
IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.
Ricardo C Ferreira, Henry Z Simons, Whitney S Thompson, Antony J Cutler, Xaquin Castro Dopico, Deborah J Smyth, Meghavi Mashar, Helen Schuilenburg, Neil M Walker, David B Dunger, Chris Wallace, John A Todd, Linda S Wicker, Marcin L Pekalski
Apr 21, 2015
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Espen Melum, Xiaojun Jiang, Kristi D Baker, M Fatima Macedo, Jürgen Fritsch, C Marie Dowds, Jing Wang, Anne Pharo, Arthur Kaser, Corey Tan, Catia S Pereira, Samuel L Kelly, Jingjing Duan, Tom H Karlsen, Mark A Exley, Stefan Schütze, Dirk M Zajonc, Alfred H Merrill, Edward H Schuchman, Sebastian Zeissig, Richard S Blumberg
Sep 23, 2019
Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as sphingomyelin. We hypothesized that these serve as endogenous regulators...
Animals Antigen Presentation Antigens CD1d Cell Differentiation Clonal Selection Antigen-Mediated Enzyme Replacement Therapy Humans Inflammation Lymphocyte Activation Lymphocyte Count Mice Mice Inbred C57BL Mice Knockout Natural Killer T-Cells Niemann-Pick Diseases Sphingomyelin Phosphodiesterase Sphingomyelins Thymus Gland
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2
John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara MD Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles JM Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch
Oct 24, 2016
The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.
Eleonora Seelig, James Howlett, Linsey Porter, Lucy Truman, James Heywood, Jane Kennet, Emma L Arbon, Katerina Anselmiova, Neil M Walker, Ravinder Atkar, Marcin L Pekalski, Ed Rytina, Mark Evans, Linda S Wicker, John A Todd, Adrian P Mander, Simon Bond, Frank Waldron-Lynch
Nov 21, 2018
Autoimmune Diseases Autoimmunity Clinical Trials Diabetes T cells Adolescent Adult Aged Diabetes mellitus Type 1 Dose-Response Relationship Drug Drug Administration Schedule Feasibility Studies Female Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Activation Lymphocyte Count Male Middle Aged Recombinant Proteins T-Lymphocytes Regulatory Treatment Outcome Young Adult
Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.
Charles JM Bell, Yongliang Sun, Urszula M Nowak, Jan Clark, Sarah Howlett, Marcin L Pekalski, Xin Yang, Oliver Ast, Inja Waldhauer, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Christian Klein, Ralf J Hosse, Linda S Wicker, Laurence B Peterson
Oct 16, 2014
Autoimmunity Cytokine therapy Graft versus host disease IL-2 fusion proteins Regulatory T cells Animals Biomarkers CTLA-4 Antigen Dose-Response Relationship Drug Eosinophilia Female Forkhead Transcription Factors Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Count Macaca fascicularis Male Mice Mice Knockout Phenotype Phosphorylation Protein Binding Recombinant Fusion Proteins Recombinant Proteins STAT5 Transcription Factor Signal Transduction T-Lymphocyte Subsets T-Lymphocytes Regulatory
Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses.
Laurence SC Lok, Jennifer A Walker, Helen E Jolin, Seth T Scanlon, Masaru Ishii, Padraic G Fallon, Andrew NJ McKenzie, Menna R Clatworthy
Sep 08, 2021
Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also...
innate lymphoid cell intravital imaging lymph node mucosa type 2 inflammation Animals Genes Reporter Interleukin-13 Intestinal Diseases Parasitic Intestinal Mucosa Intestine Small Intravital Microscopy Lymphocyte Count Lymphocyte Subsets Mice Nippostrongylus Organ Specificity Schistosomiasis mansoni Specific Pathogen-Free Organisms Strongylida Infections Th2 Cells
Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS)
Tian Xiao Zhao, Michalis Kostapanos, Charmaine Griffiths, Emma L Arbon, Annette Hubsch, Fotini Kaloyirou, Joanna Helmy, Stephen P Hoole, James HF Rudd, Graham Wood, Keith Burling, Simon Bond, Joseph Cheriyan, Ziad Mallat
Nov 07, 2018
INTRODUCTION: Inflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes (ACSs). Immune responses are also major determinants of...
Acute Coronary Syndrome aldesleukin interleukin 2 ischaemic heart disease Regulatory T cells Acute Coronary Syndrome C-Reactive Protein Clinical Trials Phase I as Topic Clinical Trials Phase II as Topic Double-Blind Method Humans Immunologic Factors Interleukin-2 Interleukin-6 Lymphocyte Count Myocardial Ischemia Natriuretic Peptide Brain Randomized Controlled Trials as Topic Recombinant Proteins T-Lymphocytes Regulatory Troponin
Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients.
HR Ali, E Provenzano, S-J Dawson, FM Blows, B Liu, M Shah, HM Earl, CJ Poole, L Hiller, JA Dunn, SJ Bowden, C Twelves, JMS Bartlett, SMA Mahmoud, E Rakha, IO Ellis, S Liu, D Gao, TO Nielsen, PDP Pharoah, C Caldas
Jul 18, 2014
Breast Cancer Chemotherapy Inflammation Lymphocytes molecular subtypes Adult Aged Antineoplastic Agents Biomarkers Tumor Breast Neoplasms CD8-Positive T-Lymphocytes Female Humans Lymphocyte Count Lymphocytes Tumor-Infiltrating Middle Aged Predictive Value of Tests Receptors Progesterone Survival Analysis Triple Negative Breast Neoplasms
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...