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Results: 3
Translational neurophysiology in sheep
Nicholas Perentos, Amadeu Q Martins, Thomas C Watson, Ullrich Bartsch, Nadia L Mitchell, David N Palmer, Matthew W Jones, A Jennifer Morton
Mar 23, 2015
NCL brain atrophy Epilepsy experimental models lysosomal storage disease neurodegeneration neuronal ceroid lipofuscinosis Seizures Animals Disease Models Animal Humans Lysosome-Associated Membrane Glycoproteins Membrane Proteins Nervous System Diseases Neuronal Ceroid-Lipofuscinoses Sheep Sleep Translational Research Biomedical
Stat3-mediated alterations in lysosomal membrane protein composition.
Bethan Lloyd-Lewis, Caroline C Krueger, Timothy J Sargeant, Michael E D'Angelo, Michael J Deery, Renata Feret, Julie A Howard, Kathryn S Lilley, Christine J Watson
Mar 22, 2018
Lysosome function is essential in cellular homeostasis. In addition to its recycling role, the lysosome has recently been recognized as a cellular signaling hub. We have shown in mammary epithelial cells, both in vivo and in...
STAT3 Cell Death involution lysosome lysosome purification mammary epithelial cells mammary gland Proteomics Animals Cell Death Cells Cultured Epithelial Cells Female Intracellular Membranes Lysosome-Associated Membrane Glycoproteins Lysosomes Mammary Glands Animal Proteome Proteomics STAT3 Transcription Factor Signal Transduction
GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C.
Peace Atakpa, Laura M van Marrewijk, Michael Apta-Smith, Sumita Chakraborty, Colin W Taylor
Jan 30, 2019
The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a...
Ca2+ signals Cathepsin C Cytosolic pH Endoplasmic Reticulum GPN lysosome Biological Transport CRISPR-Cas Systems Calcium Calcium Channels Calcium Signaling Cathepsin C Cell Line Tumor Cytosol Dipeptides Endoplasmic Reticulum Gene Editing Gene Expression Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Hydrogen-Ion Concentration Inositol 1 4 5-Trisphosphate Receptors Leukocytes Lysosome-Associated Membrane Glycoproteins Lysosomes Ploidies Ryanodine Receptor Calcium Release Channel