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Results: 119
A randomised controlled trial and cost effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in the over 65s
Dawn Swancutt, Richard Hobbs, David Fitzmaurice, Jonathan Mant, Ellen Murray, Sue Jowett, James Raftery, Stirling Bryan, Michael Davies, Gregory Lip
May 03, 2018
BACKGROUND: Atrial fibrillation (AF) has been recognised as an important independent risk factor for thromboembolic disease, particularly stroke for which it provides a five-fold increase in risk. This study aimed to determine...
Safety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients.
Wladyslaw Januszewicz, Wei Keith Tan, Katie Lehovsky, Irene Debiram-Beecham, Tara Nuckcheddy, Susan Moist, Sudarshan Kadri, Massimiliano di Pietro, Alex Boussioutas, Nicholas J Shaheen, David A Katzka, Evan S Dellon, Rebecca C Fitzgerald, BEST1 and BEST2 study investigators
Oct 03, 2018
BACKGROUND & AIMS: Diagnosis and surveillance of Barrett's esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge is a novel, minimally invasive esophageal cell collection device....
Acceptability of Healthcare Medical device Safety Aged Barrett Esophagus Cytological Techniques Eosinophilic Esophagitis Equipment and Supplies Female Humans Male Mass Screening Middle Aged Patient Acceptance of Health Care Patient Safety Prospective Studies Retrospective Studies Risk Factors Specimen Handling
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults
Michael Inouye, Gad Abraham, Christopher P Nelson, Angela M Wood, Michael J Sweeting, Frank Dudbridge, Florence Y Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K Rutter, Ioanna Tzoulaki, Riyaz S Patel, Ruth JF Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh, Nilesh J Samani, UK Biobank CardioMetabolic Consortium CHD working group
Nov 22, 2018
BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because...
Coronary Artery Disease genomic risk prediction Primary Prevention Coronary Artery Disease Female Genome-Wide Association Study Genomics Humans Male Mass Screening Middle Aged Multifactorial Inheritance Predictive Value of Tests Primary Prevention Research Design Risk Assessment Risk Factors United Kingdom
Universal screening for foetal growth restriction.
Gordon CS Smith
Jun 01, 2018
Foetal growth restriction (FGR) is a major cause of morbidity and mortality. Clinical methods for identifying women whose pregnancies are affected by FGR do not perform well. Despite this, the current approach to screening...
biomarker Doppler Foetal growth restriction Placenta screening ULTRASOUND Biomarkers Biometry Female Fetal Growth Retardation Gestational Age Humans Infant Newborn Mass Screening Placenta Predictive Value of Tests Pregnancy Prenatal Care Randomized Controlled Trials as Topic Research Design Risk Factors Ultrasonography Prenatal
Opportunities and barriers for providing HIV testing through community health centers in mainland China
Jason J Ong, Ming Hui Peng, William W Wong, Ying-Ru Lo, Michael R Kidd, Martin Roland, Shan Zhu Zhu, Sun Fang Jiang
Jan 03, 2020
BACKGROUND: Primary care may be an avenue to increase coverage of HIV testing but it is unclear what challenges primary healthcare professionals in low- and middle-income countries face. We describe the HIV testing practices in...
China Community Health Centre HIV PRIMARY CARE testing Adult Attitude of Health Personnel China Community Health Centers Cross-Sectional Studies Diagnostic Tests Routine Education Medical Education Nursing Female HIV HIV Infections Humans insurance health Reimbursement Logistic Models Male Mass Screening Middle Aged Nurses Physicians Primary Health Care Risk Factors Serologic Tests Surveys and Questionnaires
Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care
Simon J Griffin, Guy EHM Rutten, Kamlesh Khunti, Daniel R Witte, Torsten Lauritzen, Stephen J Sharp, Else-Marie Dalsgaard, Melanie J Davies, Greg J Irving, Rimke C Vos, David R Webb, Nicholas J Wareham, Annelli Sandbæk
Jan 15, 2020
Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening
Nicole Lowres, Jake Olivier, Tze-Fan Chao, Shih-Ann Chen, Yi Chen, Axel Diederichsen, David A Fitzmaurice, Juan Jose Gomez-Doblas, Joseph Harbison, Jeff S Healey, FD Richard Hobbs, Femke Kaasenbrood, William Keen, Vivian W Lee, Jes S Lindholt, Gregory YH Lip, Georges H Mairesse, Jonathan Mant, Julie W Martin, Enrique Martín-Rioboó, David D McManus, Javier Muñiz, Thomas Münzel, Juliet Nakamya, Lis Neubeck, Jessica J Orchard, Luis Ángel Pérula de Torres, Marco Proietti, F Russell Quinn, Andrea K Roalfe, Roopinder K Sandhu, Renate B Schnabel, Breda Smyth, Apurv Soni, Robert Tieleman, Jiguang Wang, Philipp S Wild, Bryan P Yan, Ben Freedman
Sep 04, 2019
Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting.
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes....
Evaluation of FTIR spectroscopy as a diagnostic tool for lung cancer using sputum.
Paul D Lewis, Keir E Lewis, Robin Ghosal, Sion Bayliss, Amanda J Lloyd, John Wills, Ruth Godfrey, Philip Kloer, Luis AJ Mur
May 13, 2020
BACKGROUND: Survival time for lung cancer is poor with over 90% of patients dying within five years of diagnosis primarily due to detection at late stage. The main objective of this study was to evaluate Fourier transform...
Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes
L Tao, ECF Wilson, NJ Wareham, A Sandbaek, GEHM Rutten, T Lauritzen, K Khunti, MJ Davies, K Borch-Johnsen, SJ Griffin, RK Simmons
Aug 11, 2014
Aged Cluster Analysis Cohort Studies Combined Modality Therapy Cost-Benefit Analysis Diabetes Complications Diabetes mellitus Type 2 Female Health Care Costs Humans Incidence Male Mass Screening Middle Aged Patient Education as Topic Patient-Centered Care Quality-Adjusted Life Years Risk Factors Time Factors United Kingdom
HIV and syphilis testing behaviors among heterosexual male and female sex workers in Uganda.
Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba
Sep 11, 2020
BACKGROUND: In Sub-Saharan Africa where HIV disproportionately affects women, heterosexual male sex workers (HMSW) and their female clients are at risk of acquiring or transmitting HIV and other STIs. However, few studies have...
Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes
E-M Dalsgaard, A Sandbaek, SJ Griffin, GEHM Rutten, K Khunti, MJ Davies, GJ Irving, RC Vos, DR Webb, NJ Wareham, DR Witte
Jul 29, 2020
AIMS: To present the longer-term impact of multifactorial treatment of type 2 diabetes on self-reported health status, diabetes-specific quality of life, and diabetes treatment satisfaction at 10-year follow up of the...
Mass testing of university students for covid-19.
People can clearly incubate and transmit SARS-CoV-2 in the absence of symptoms. Nonetheless, the value of mass testing (large scale asymptomatic screening to identify cases) has been contested. In principle, isolation of people...
The Costs and Benefits of Risk Stratification for Colorectal Cancer Screening Based On Phenotypic and Genetic Risk
Chloe Thomas, Olena Mandrik, Catherine L Saunders, Deborah Thompson, Sophie Whyte, Simon Griffin, Juliet A Usher-Smith
May 28, 2021
Population-based screening for colorectal cancer is an effective and cost-effective way of reducing colorectal cancer incidence and mortality. Many genetic and phenotypic risk factors for colorectal cancer have been identified...
Adult Aged Aged 80 and over Colonoscopy Colorectal Neoplasms Cost-Benefit Analysis Early Detection of Cancer England Female Genetic Predisposition to Disease Genetic Testing Humans Incidence Life Style Male Mass Screening Middle Aged Models Statistical Occult Blood Phenotype Risk Assessment Risk Factors State Medicine
Validation and public health modelling of risk prediction models for kidney cancer using the UK Biobank.
Hannah Harrison, Lisa Pennells, Angela Wood, Sabrina H Rossi, Grant D Stewart, Simon J Griffin, Juliet A Usher-Smith
Sep 14, 2021
Delivering screening programmes in primary care
Rakesh Narendra Modi, Sarah Kelly, Sarah Hoare, Alison Powell, Isla Kuhn, Juliet Usher-Smith, Jonathan Mant, Jenni Burt
Apr 07, 2021
INTRODUCTION: Screening programmes represent a considerable amount of healthcare activity. As complex interventions, they require careful delivery to generate net benefit. Much screening work occurs in primary care. Despite...
Acceptability and potential impact on uptake of using different risk stratification approaches to determine eligibility for screening
Juliet A Usher-Smith, Laragh LW Harvey-Kelly, Sabrina H Rossi, Hannah Harrison, Simon J Griffin, Grant D Stewart
Nov 17, 2020
A Decision Analysis Evaluating Screening for Kidney Cancer Using Focused Renal Ultrasound.
Sabrina H Rossi, Tobias Klatte, Juliet A Usher-Smith, Kate Fife, Sarah J Welsh, Saeed Dabestani, Axel Bex, David Nicol, Paul Nathan, Grant D Stewart, Edward Cf Wilson
Sep 13, 2019
Gastro-esophageal reflux disease symptoms and demographic factors as a pre-screening tool for Barrett's esophagus.
Xinxue Liu, Angela Wong, Sudarshan R Kadri, Andrej Corovic, Maria O'Donovan, Pierre Lao-Sirieix, Laurence B Lovat, Rodney W Burnham, Rebecca C Fitzgerald
Feb 13, 2020
BACKGROUND: Barrett's esophagus (BE) occurs as consequence of reflux and is a risk factor for esophageal adenocarcinoma. The current "gold-standard" for diagnosing BE is endoscopy which remains prohibitively expensive and...
Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge)
Rebecca K Simmons, Justin B Echouffo-Tcheugui, Stephen J Sharp, Lincoln A Sargeant, Kate M Williams, A Toby Prevost, Ann Louise Kinmonth, Nicholas J Wareham, Simon J Griffin
Jun 12, 2018
BACKGROUND: The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, uncertainty persists...
Investigating diagnostic bias in autism spectrum conditions
Aja Louise Murray, Carrie Allison, Paula L Smith, Simon Baron-Cohen, Tom Booth, Bonnie Auyeung
Mar 23, 2017
Diagnostic bias is a concern in autism spectrum conditions (ASC) where prevalence and presentation differ by sex. To ensure that females with ASC are not under-identified, it is important that ASC screening tools do not...
AQ-10 autism Autism Spectrum Quotient differential item functioning differential test functioning item response theory screening Sex differences Adolescent Adult Autism spectrum disorder Child Child Preschool Cross-Sectional Studies Diagnostic Errors Female Humans Infant Infant Newborn Male Mass Screening Psychometrics Reproducibility of Results Sexism Surveys and Questionnaires Young Adult
Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.
Lois G Kim, Michael J Sweeting, Morag Armer, Jo Jacomelli, Akhtar Nasim, Seamus C Harrison
Jul 28, 2021
Background
The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for...
Humans Aortic Rupture Aortic Aneurysm Abdominal Ultrasonography Mass Screening Severity of Illness Index Models Statistical Risk Assessment Risk Factors Age Factors Communicable Disease Control Cost of Illness Health Policy Computer Simulation Aged State Medicine Patient Acceptance of Health Care England Male Pandemics Time-to-Treatment Elective Surgical Procedures covid-19
Published by: PLOS ONE
Effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low-income and middle-income countries
OBJECTIVES: To systematically synthesise available evidence on the nature and effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low and middle-income countries (LMICs). DESIGN: A...
Acceptability of screening for mental health difficulties in primary schools
Emma Soneson, Jasmine Childs-Fegredo, Joanna K Anderson, Jan Stochl, Mina Fazel, Tamsin Ford, Ayla Humphrey, Peter B Jones, Emma Howarth
Jan 07, 2019
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