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Results: 11
Maternal Dexamethasone Treatment Alters Tissue and Circulating Components of the Renin-Angiotensin System in the Pregnant Ewe and Fetus.
Alison J Forhead, Juanita K Jellyman, Miles J De Blasio, Emma Johnson, Dino A Giussani, Fiona Broughton Pipkin, Abigail L Fowden
Jun 18, 2015
Intergenerational effects of maternal birth season on offspring size in rural Gambia.
Ian J Rickard, Alexandre Courtiol, Andrew M Prentice, Anthony JC Fulford, Tim H Clutton-Brock, Virpi Lummaa
May 03, 2021
Environmental conditions experienced in early life can influence an individual's growth and long-term health, and potentially also that of their offspring. However, such developmental effects on intergenerational outcomes have...
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Laís Vales Mennitti, Asha AM Carpenter, Elena Loche, Lucas C Pantaleão, Denise S Fernandez-Twinn, Josca M Schoonejans, Heather L Blackmore, Thomas J Ashmore, Luciana Pellegrini Pisani, John A Tadross, Iain Hargreaves, Susan E Ozanne
Jan 28, 2022
OBJECTIVE: This study investigated the effect of maternal obesity on aged-male offspring liver phenotype and hepatic expression of a programmed miRNA. METHODS: A mouse model (C57BL/6 J) of maternal diet-induced obesity was used...
Maternal ambient air pollution exposure with spatial-temporal variations and preterm birth risk assessment during 2013-2017 in Zhejiang Province, China.
Zhe Sun, Liyang Yang, Xiaoxia Bai, Wei Du, Guofeng Shen, Jie Fei, Yonghui Wang, An Chen, Yuanchen Chen, Meirong Zhao
Sep 16, 2021
Preterm birth (PTB) can give rise to significant neonatal morbidity and mortality, as well as children's long-term health defects. Many studies have illustrated the associations between ambient air pollution exposure during...
Antenatal Exposure to UV-B Radiation and Preeclampsia
Claire E Hastie, Daniel F Mackay, Tom L Clemens, Mark PC Cherrie, Lauren J Megaw, Gordon CS Smith, Sarah J Stock, Chris Dibben, Jill P Pell
May 24, 2021
Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.
Jane L Tarry-Adkins, Denise S Fernandez-Twinn, Ralitsa Madsen, Jian-Hua Chen, Asha Carpenter, Iain P Hargreaves, Josie M McConnell, Susan E Ozanne
Aug 03, 2015
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.
Sinjini Sikdar, Roby Joehanes, Bonnie R Joubert, Cheng-Jian Xu, Marta Vives-Usano, Faisal I Rezwan, Janine F Felix, James M Ward, Weihua Guan, Rebecca C Richmond, Jennifer A Brody, Leanne K Küpers, Nour Baïz, Siri E Håberg, Jennifer A Smith, Sarah E Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A Markunas, Tao Xu, Lindsay M Reynolds, Allan C Just, Pooja R Mandaviya, Akram Ghantous, Brian D Bennett, Tianyuan Wang, The Bios Consortium, Kelly M Bakulski, Erik Melen, Shanshan Zhao, Jianping Jin, Zdenko Herceg, Joyce van Meurs, Jack A Taylor, Andrea A Baccarelli, Susan K Murphy, Yongmei Liu, Monica Cheng Munthe-Kaas, Ian J Deary, Wenche Nystad, Melanie Waldenberger, Isabella Annesi-Maesano, Karen Conneely, Vincent WV Jaddoe, Donna Arnett, Harold Snieder, Sharon LR Kardia, Caroline L Relton, Ken K Ong, Susan Ewart, Hortensia Moreno-Macias, Isabelle Romieu, Nona Sotoodehnia, Myriam Fornage, Alison Motsinger-Reif, Gerard H Koppelman, Mariona Bustamante, Daniel Levy, Stephanie J London
Oct 08, 2019
Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown....
Intrauterine programming of obesity and type 2 diabetes.
developmental programming Epigenetic variation Intrauterine programming Life course development Maternal exposures MicroRNAs obesity Paternal exposures Review Type 2 diabetes Animals Diabetes mellitus Type 2 Epigenesis Genetic Female Humans Maternal Exposure obesity Pregnancy prenatal exposure delayed effects Uterus
Generation of the Maternal Low-Protein Rat Model for Studies of Metabolic Disorders.
Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal...
Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.
Jessy Cartier, Thomas Smith, John P Thomson, Catherine M Rose, Batbayar Khulan, Andreas Heger, Richard R Meehan, Amanda J Drake
Sep 08, 2018
BACKGROUND: Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines...
DNA Methylation Early life programming epigenetic Germline transmission Glucocorticoids Histone modifications small RNA Animals Birth Weight DNA Methylation Dexamethasone Epigenesis Genetic Female Glucocorticoids Histone Code Male Maternal Exposure RNA Small Untranslated Rats Sprague-Dawley Spermatozoa