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Results: 31
Breast cancer risk factors and their effects on survival
Maria Escala-Garcia, Anna Morra, Sander Canisius, Jenny Chang-Claude, Siddhartha Kar, Wei Zheng, Stig E Bojesen, Doug Easton, Paul DP Pharoah, Marjanka K Schmidt
Dec 16, 2020
BACKGROUND: Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential...
Breast cancer risk factors and their effects on survival
Maria Escala-Garcia, Anna Morra, Sander Canisius, Jenny Chang-Claude, Siddhartha Kar, Wei Zheng, Stig E. Bojesen, Doug Easton, Paul D. P. Pharoah, Marjanka K. Schmidt
Nov 17, 2020
Abstract: Background: Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to...
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity
Tom A Bond, Rebecca C Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C Yang, Marc J Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M Evans, Alex M Lewin, Paul F O'Reilly, Deborah A Lawlor, Marjo-Riitta Järvelin
Mar 05, 2022
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms...
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases
Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M Mason, Stephen Burgess, Susanna Larsson
Dec 11, 2019
?5-desaturase FADS Mendelian randomisation cardiovascular disease Diet Fatty Acids Alleles Arachidonic Acid Cardiovascular Diseases Data analysis Delta-5 Fatty Acid Desaturase Fatty Acid Desaturases Fatty Acids Genetic Predisposition to Disease Humans Linoleic Acid Mendelian Randomization Analysis Odds Ratio Oleic Acid Phospholipids Polymorphism Single Nucleotide Protective factors Risk Factors Stearic Acids alpha-Linolenic Acid
Role of inflammation in depression and anxiety
Zheng Ye, Nils Kappelmann, Sylvain Moser, George Davey Smith, Stephen Burgess, Peter B Jones, Golam M Khandaker
Jun 14, 2021
BACKGROUND: Concentrations of C-reactive protein (CRP), interleukin 6 (IL-6) and other inflammatory markers are elevated in people with depression and anxiety compared to controls, but evidence for disorder-specificity...
Causal relationship between polycystic ovary syndrome and coronary artery disease
Pomme I. H. G. Simons, Merel E. B. Cornelissen, Olivier Valkenburg, N. Charlotte Onland‐Moret, Yvonne T. van der Schouw, Coen D.A. Stehouwer, Stephen Burgess, Martijn C. G. J. Brouwers
Sep 15, 2021
2 ORIGINAL ARTICLE ‐ EUROPE EXCLUDING UK 2 ORIGINAL ARTICLE ‐ EUROPE EXCLUDING UK (CEN) Coronary Artery Disease Mendelian randomisation obesity POLYCYSTIC OVARY SYNDROME
Published by: Clinical Endocrinology
Alcohol consumption and prostate cancer incidence and progression
Clair Brunner, Neil M Davies, Richard M Martin, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Jenny Donovan, Freddie C Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Luisa Zuccolo
Sep 22, 2016
Mendelian randomisation Alcohol alcohol metabolising genes prostate cancer Aged Aged 80 and over Alcohol Drinking Aldehyde Dehydrogenase Aldehyde Dehydrogenase 1 Family Aldehyde Dehydrogenase Mitochondrial Case-Control Studies Disease Progression Humans Incidence Linkage Disequilibrium Male Middle Aged Neoplasm Grading Polymorphism Single Nucleotide Prostatic Neoplasms Regression Analysis Retinal Dehydrogenase Survival Analysis
IGF-1 and cardiometabolic diseases
Abstract: Aims/hypothesis: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic...
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
Chen Li, Svetlana Stoma, Luca A Lotta, Sophie Warner, Eva Albrecht, Alessandra Allione, Pascal P Arp, Linda Broer, Jessica L Buxton, Alexessander Da Silva Couto Alves, Joris Deelen, Iryna O Fedko, Scott D Gordon, Tao Jiang, Robert Karlsson, Nicola Kerrison, Taylor K Loe, Massimo Mangino, Yuri Milaneschi, Benjamin Miraglio, Natalia Pervjakova, Alessia Russo, Ida Surakka, Ashley van der Spek, Josine E Verhoeven, Najaf Amin, Marian Beekman, Alexandra I Blakemore, Federico Canzian, Stephen E Hamby, Jouke-Jan Hottenga, Peter D Jones, Pekka Jousilahti, Reedik Mägi, Sarah E Medland, Grant W Montgomery, Dale R Nyholt, Markus Perola, Kirsi H Pietiläinen, Veikko Salomaa, Elina Sillanpää, H Eka Suchiman, Diana van Heemst, Gonneke Willemsen, Antonio Agudo, Heiner Boeing, Dorret I Boomsma, Maria-Dolores Chirlaque, Guy Fagherazzi, Pietro Ferrari, Paul Franks, Christian Gieger, Johan Gunnar Eriksson, Marc Gunter, Sara Hägg, Iiris Hovatta, Liher Imaz, Jaakko Kaprio, Rudolf Kaaks, Timothy Key, Vittorio Krogh, Nicholas G Martin, Olle Melander, Andres Metspalu, Concha Moreno, N Charlotte Onland-Moret, Peter Nilsson, Ken K Ong, Kim Overvad, Domenico Palli, Salvatore Panico, Nancy L Pedersen, Brenda WJH Penninx, J Ramón Quirós, Marjo Riitta Jarvelin, Miguel Rodríguez-Barranco, Robert A Scott, Gianluca Severi, P Eline Slagboom, Tim D Spector, Anne Tjonneland, Antonia Trichopoulou, Rosario Tumino, André G Uitterlinden, Yvonne T van der Schouw, Cornelia M van Duijn, Elisabete Weiderpass, Eros Lazzerini Denchi, Giuseppe Matullo, Adam S Butterworth, John Danesh, Nilesh J Samani, Nicholas J Wareham, Christopher P Nelson, Claudia Langenberg, Veryan Codd
Feb 21, 2020
Investigating evidence for a causal association between inflammation and self-harm
Abigail Emma Russell, Tamsin Ford, David Gunnell, Jon Heron, Carol Joinson, Paul Moran, Caroline Relton, Matthew Suderman, Gibran Hemani, Becky Mars
May 28, 2020
BACKGROUND: The causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question...
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity
Tom A Bond, Rebecca C Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C Yang, Marc J Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M Evans, Alex M Lewin, Paul F O'Reilly, Deborah A Lawlor, Marjo-Riitta Järvelin
Feb 01, 2022
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms...
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression
Roberto Bonelli, Brendan R. E. Ansell, Luca Lotta, Thomas Scerri, Traci E. Clemons, Irene Leung, Tunde Peto, Alan C. Bird, Ferenc B. Sallo, Claudia Langenberg, Melanie Bahlo
Mar 09, 2021
Abstract: Background: Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend retinal vascular calibre and...
Causal relationship between polycystic ovary syndrome and coronary artery disease
Pomme IHG Simons, Merel EB Cornelissen, Olivier Valkenburg, N Charlotte Onland-Moret, Yvonne T van der Schouw, Coen DA Stehouwer, Stephen Burgess, Martijn CGJ Brouwers
Sep 24, 2021
OBJECTIVE: Polycystic ovary syndrome (PCOS) has been associated with an increased risk of coronary artery disease (CAD). However, it remains uncertain whether this increased risk is the result of PCOS per se or, alternatively...
Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans.
Susanna Lemmelä, Eleanor M Wigmore, Christian Benner, Aki S Havulinna, Rachel MY Ong, Tibor Kempf, Kai C Wollert, Stefan Blankenberg, Tanja Zeller, James E Peters, Veikko Salomaa, Maria Fritsch, Ruth March, Aarno Palotie, Mark Daly, Adam S Butterworth, Mervi Kinnunen, Dirk S Paul, Athena Matakidou
Sep 02, 2022
Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans.
Susanna Lemmelä, Eleanor M Wigmore, Christian Benner, Aki S Havulinna, Rachel MY Ong, Tibor Kempf, Kai C Wollert, Stefan Blankenberg, Tanja Zeller, James E Peters, Veikko Salomaa, Maria Fritsch, Ruth March, Aarno Palotie, Mark Daly, Adam S Butterworth, Mervi Kinnunen, Dirk S Paul, Athena Matakidou
Aug 19, 2022
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M. Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F. Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G. Panayiotou, N. Charlotte Onland-Moret, Yvonne T. van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J. Wareham, Claudia Langenberg, Robert A. Scott, Jian’an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E. Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S. Carrell, Catherine A. McCarty, Kirchner H. Lester, Eric B. Larson, David R. Crosslin, Mariza de Andrade, Dan M. Roden, Joshua C. Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O’Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M. Abdullah Said, Ruben N. Eppinga, Niek Verweij, Harold Snieder, Tim Christen, D. O. Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M. Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P. Pell, Tom Meade, Ingrid E. Christophersen, Anke H. Maitland-van der Zee, Ekaterina V. Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L. Bots, Diederick E. Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C. Hopewell, Sudha Seshadri, Caroline Dale, Rui Providencia E. Costa, Paul M. Ridker, Daniel I. Chasman, Alex P. Reiner, Marylyn D. Ritchie, Leslie A. Lange, Alex J. Cornish, Sara E. Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W. Asselbergs, Riyaz S. Patel, Brendan J. Keating, Naveed Sattar, Richard Houlston, Juan P. Casas, Aroon D. Hingorani
Oct 28, 2020
Abstract: Background: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods: Published and individual...
IGF-1 and cardiometabolic diseases
AIMS/HYPOTHESIS: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease...
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Amand F Schmidt, Michael V Holmes, David Preiss, Daniel I Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert A Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, Kirchner H Lester, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O'Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Lifelines Cohort authors, Tim Christen, DO Mook-Kanamori, ICBP Consortium, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Tom Meade, Ingrid E Christophersen, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C Hopewell, Sudha Seshadri, METASTROKE Consortium of the ISGC, Caroline Dale, Rui Providencia E Costa, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Marylyn D Ritchie, Leslie A Lange, Alex J Cornish, Sara E Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W Asselbergs, Riyaz S Patel, Brendan J Keating, Naveed Sattar, Richard Houlston, Juan P Casas, Aroon D Hingorani
Aug 22, 2019
Genetic Association Studies LDL-cholesterol Mendelian randomisation Phenome-wide association scan Anticholesteremic Agents Biomarkers Brain Ischemia Cholesterol LDL Down-Regulation Dyslipidemias Genome-Wide Association Study Humans Myocardial Infarction PCSK9 Inhibitors Polymorphism Single Nucleotide Proprotein Convertase 9 Randomized Controlled Trials as Topic Risk Assessment Risk Factors Serine Proteinase Inhibitors stroke Treatment Outcome
Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring
INTRODUCTION: Limited evidence from birth cohort studies suggests that lower prenatal iron status may be a risk factor for childhood respiratory and atopic outcomes, but these observational findings may be confounded. Mendelian...
Milk intake and incident stroke and CHD in populations of European descent
LET Vissers, I Sluijs, S Burgess, NG Forouhi, H Freisling, F Imamura, TK Nilsson, F Renström, E Weiderpass, K Aleksandrova, CC Dahm, A Perez-Cornago, MB Schulze, TYN Tong, D Aune, C Bonet, JMA Boer, H Boeing, MD Chirlaque, MI Conchi, L Imaz, S Jäger, V Krogh, C Kyrø, G Masala, O Melander, K Overvad, S Panico, MJ Sánches, E Sonestedt, A Tjønneland, I Tzoulaki, WMM Verschuren, E Riboli, NJ Wareham, J Danesh, AS Butterworth, YT van der Schouw
Oct 28, 2021
Higher milk intake has been associated with a lower stroke risk, but not with risk of CHD. Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with...
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases
Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M. Mason, Stephen Burgess, Susanna Larsson
Dec 10, 2019
Whether circulating fatty acids (FAs) play a causal role in the development of cardiovascular disease (CVD) remains unclear. We conducted a Mendelian randomisation study to explore the associations between plasma phospholipid FA...
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia CM Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten, IMPROVE study group
Feb 02, 2018
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease...
Atherosclerosis Genetic variants Intima-media-thickness Mendelian randomisation Proinsulin SINGLE NUCLEOTIDE POLYMORPHISMS Asymptomatic Diseases Carotid Artery Diseases Carotid Intima-Media Thickness Chromosomes Human Pair 15 Europe Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Linear Models Male Mendelian Randomization Analysis Phenotype Polymorphism Single Nucleotide Proinsulin Quantitative Trait Loci Risk Factors Vascular Remodeling
Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
Stephen Burgess, Rainer Malik, Bowen Liu, Amy M Mason, Marios K Georgakis, Martin Dichgans, Dipender Gill
Nov 20, 2020
AIMS/HYPOTHESIS: Our aim was to investigate the relationship between average blood glucose levels and incident CHD in individuals without diabetes mellitus. METHODS: To investigate average blood glucose levels, we studied HbA1c...
Average blood glucose levels CHD Mendelian randomisation Adult Aged Biomarkers Blood Glucose Coronary Disease Female Genetic Predisposition to Disease Glycated Hemoglobin Humans Incidence Male Mendelian Randomization Analysis Middle Aged Phenotype Polymorphism Single Nucleotide Time Factors United Kingdom
Prioritising Risk Factors for Type 2 Diabetes
PURPOSE OF THE REVIEW: Causality has been demonstrated for few of the many putative risk factors for type 2 diabetes (T2D) emerging from observational epidemiology. Genetic approaches are increasingly being used to infer...
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