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Convergence of Prognostic Gene Signatures Suggests Underlying Mechanisms of Human Prostate Cancer Progression.
Bogdan-Alexandru Luca, Vincent Moulton, Christopher Ellis, Shea P Connell, Daniel S Brewer, Colin S Cooper
Oct 02, 2020
The highly heterogeneous clinical course of human prostate cancer has prompted the development of multiple RNA biomarkers and diagnostic tools to predict outcome for individual patients. Biomarker discovery is often unstable...
aggressive cancer Biomarkers cancer progression diagnostic signature prognostic signature prostate cancer Biomarkers Tumor Cohort Studies Datasets as Topic Disease Progression Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Microarray Analysis Neoplasm Invasiveness Prognosis Prostatic Neoplasms Transcriptome
When Bio Meets Technology
Amy E Rochford, Alejandro Carnicer-Lombarte, Vincenzo F Curto, George G Malliaras, Damiano G Barone
Aug 29, 2019
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming.
Thomas Moreau, Amanda L Evans, Louella Vasquez, Marloes R Tijssen, Ying Yan, Matthew W Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M Hobbs, Dean C Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H Ouwehand, Roger A Pedersen, Cedric Ghevaert
Feb 09, 2016
Basic Helix-Loop-Helix Transcription Factors Blood Platelets Cell Culture Techniques Cell Differentiation Cell Proliferation Cellular Reprogramming Cryopreservation GATA1 Transcription Factor Gene Expression Regulation Genes Reporter Genetic Vectors Green Fluorescent Proteins Humans Lentivirus Megakaryocytes Microarray Analysis Pluripotent Stem Cells Proto-Oncogene Protein c-fli-1 Proto-Oncogene Proteins Signal Transduction T-Cell Acute Lymphocytic Leukemia Protein 1 Transduction Genetic Transgenes
Regulation of microRNA during cardiomyocyte maturation in sheep.
Janna L Morrison, Song Zhang, Ross L Tellam, Doug A Brooks, I Caroline McMillen, Enzo R Porrello, Kimberley J Botting
Sep 29, 2016
BACKGROUND: There is a limited capacity to repair damage in the mammalian heart after birth, which is primarily due to the inability of cardiomyocytes to proliferate after birth. This is in contrast to zebrafish and salamander...
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Kyriaki Michailidou, Jonathan Beesley, Sara Lindstrom, Sander Canisius, Joe Dennis, Michael J Lush, Mel J Maranian, Manjeet K Bolla, Qin Wang, Mitul Shah, Barbara J Perkins, Kamila Czene, Mikael Eriksson, Hatef Darabi, Judith S Brand, Stig E Bojesen, Børge G Nordestgaard, Henrik Flyger, Sune F Nielsen, Nazneen Rahman, Clare Turnbull, BOCS, Olivia Fletcher, Julian Peto, Lorna Gibson, Isabel dos-Santos-Silva, Jenny Chang-Claude, Dieter Flesch-Janys, Anja Rudolph, Ursula Eilber, Sabine Behrens, Heli Nevanlinna, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Sofia Khan, Kirsimari Aaltonen, Habibul Ahsan, Muhammad G Kibriya, Alice S Whittemore, Esther M John, Kathleen E Malone, Marilie D Gammon, Regina M Santella, Giske Ursin, Enes Makalic, Daniel F Schmidt, Graham Casey, David J Hunter, Susan M Gapstur, Mia M Gaudet, W Ryan Diver, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Loic Le Marchand, Christine D Berg, Stephen J Chanock, Jonine Figueroa, Robert N Hoover, Diether Lambrechts, Patrick Neven, Hans Wildiers, Erik van Limbergen, Marjanka K Schmidt, Annegien Broeks, Senno Verhoef, Sten Cornelissen, Fergus J Couch, Janet E Olson, Emily Hallberg, Celine Vachon, Quinten Waisfisz, Hanne Meijers-Heijboer, Muriel A Adank, Rob B van der Luijt, Jingmei Li, Jianjun Liu, Keith Humphreys, Daehee Kang, Ji-Yeob Choi, Sue K Park, Keun-Young Yoo, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Pascal Guénel, Thérèse Truong, Claire Mulot, Marie Sanchez, Barbara Burwinkel, Frederik Marme, Harald Surowy, Christof Sohn, Anna H Wu, Chiu-Chen Tseng, David Van Den Berg, Daniel O Stram, Anna González-Neira, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Xiao-Ou Shu, Wei Lu, Yu-Tang Gao, Hui Cai, Angela Cox, Simon S Cross, Malcolm Wr Reed, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, kConFab Investigators, AOCS Group, Annika Lindblom, Sara Margolin, Soo Hwang Teo, Cheng Har Yip, Nur Aishah Mohd Taib, Gie-Hooi Tan, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, J Margriet Collée, William Blot, Lisa B Signorello, Qiuyin Cai, John L Hopper, Melissa C Southey, Helen Tsimiklis, Carmel Apicella, Chen-Yang Shen, Chia-Ni Hsiung, Pei-Ei Wu, Ming-Feng Hou, Vessela N Kristensen, Silje Nord, Grethe I Grenaker Alnaes, NBCS, Graham G Giles, Roger L Milne, Catriona Mclean, Federico Canzian, Dimitrios Trichopoulos, Petra Peeters, Eiliv Lund, Malin Sund, Kay-Tee Khaw, Marc J Gunter, Domenico Palli, Lotte Maxild Mortensen, Laure Dossus, Jose-Maria Huerta, Alfons Meindl, Rita K Schmutzler, Christian Sutter, Rongxi Yang, Kenneth Muir, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Mikael Hartman, Hui Miao, Kee Seng Chia, Ching Wan Chan, Peter A Fasching, Alexander Hein, Matthias W Beckmann, Lothar Haeberle, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Alan Ashworth, Nick Orr, Minouk J Schoemaker, Anthony J Swerdlow, Louise Brinton, Montserrat Garcia-Closas, Wei Zheng, Sandra L Halverson, Martha Shrubsole, Jirong Long, Mark S Goldberg, France Labrèche, Martine Dumont, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Hiltrud Brauch, Ute Hamann, Thomas Brüning, GENICA Network, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Loris Bernard, Natalia V Bogdanova, Thilo Dörk, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Peter Devilee, Robert AEM Tollenaar, Caroline Seynaeve, Christi J van Asperen, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Tomasz Huzarski, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James McKay, Susan Slager, Amanda E Toland, Christine B Ambrosone, Drakoulis Yannoukakos, Maria Kabisch, Diana Torres, Susan L Neuhausen, Hoda Anton-Culver, Craig Luccarini, Caroline Baynes, Shahana Ahmed, Catherine S Healey, Daniel C Tessier, Daniel Vincent, Francois Bacot, Guillermo Pita, M Rosario Alonso, Nuria Álvarez, Daniel Herrero, Jacques Simard, Paul PDP Pharoah, Peter Kraft, Alison M Dunning, Georgia Chenevix-Trench, Per Hall, Douglas F Easton
May 19, 2015
LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.
Lalarukh Haris Shaikh, Junhua Zhou, Ada ED Teo, Sumedha Garg, Sudeshna Guha Neogi, Nichola Figg, Giles S Yeo, Haixiang Yu, Janet J Maguire, Wanfeng Zhao, Martin R Bennett, Elena AB Azizan, Anthony P Davenport, Grahame McKenzie, Morris J Brown
Jun 05, 2015
Fetal hydrops and the Incremental yield of Next-generation sequencing over standard prenatal Diagnostic testing (FIND) study
F Mone, RY Eberhardt, ME Hurles, DJ McMullan, ER Maher, J Lord, LS Chitty, E Dempsey, T Homfray, JL Giordano, RJ Wapner, L Sun, TN Sparks, ME Norton, MD Kilby
Oct 01, 2021
OBJECTIVE: To determine the incremental yield of exome sequencing (ES) over chromosomal microarray analysis (CMA) or karyotyping in prenatally diagnosed non-immune hydrops fetalis (NIHF). METHODS: A prospective cohort study...
O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.
Connor Sharp, Christine Boinett, Amy Cain, Nicholas G Housden, Sandip Kumar, Keith Turner, Julian Parkhill, Colin Kleanthous
Aug 20, 2019
The outer membrane of Gram-negative bacteria presents a significant barrier for molecules entering the cell. Nevertheless, colicins, which are antimicrobial proteins secreted by Escherichia coli, can target other E. coli cells...
bacteriocins cell envelope enteric bacteria outer membrane Anti-Bacterial Agents Colicins DNA Transposable Elements Drug Resistance Bacterial Gene Silencing metabolism Microarray Analysis Microbial Sensitivity Tests Mutagenesis Insertional O Antigens Phenotype Sequence Analysis DNA Uropathogenic Escherichia coli
Comparative evaluation of linear and exponential amplification techniques for expression profiling at the single-cell level
Background: Single-cell microarray expression profiling requires 10(8)-10(9)-fold amplification of the picogram amounts of total RNA typically found in eukaryotic cells. Several methods for RNA amplification are in general use...
Transcriptional networks controlling the cell cycle.
Martin Bonke, Mikko Turunen, Maria Sokolova, Anna Vähärautio, Teemu Kivioja, Minna Taipale, Mikael Björklund, Jussi Taipale
Nov 04, 2020
In this work, we map the transcriptional targets of 107 previously identified Drosophila genes whose loss caused the strongest cell-cycle phenotypes in a genome-wide RNA interference screen and mine the resulting data...
Animals CDC2 Protein Kinase Cell Cycle Cell Line Cell Size Chromatin Immunoprecipitation Cluster Analysis Drosophila Feedback Physiological Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Microarray Analysis Mitosis Oligonucleotides Phosphorylation RNA Interference Sequence Analysis RNA
Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining.
Maria Jose Cabello-Lobato, Matthew Jenner, Metztli Cisneros-Aguirre, Kira Brüninghoff, Zac Sandy, Isabelle C da Costa, Thomas A Jowitt, Christian M Loch, Stephen P Jackson, Qian Wu, Henning D Mootz, Jeremy M Stark, Matthew J Cliff, Christine K Schmidt
May 14, 2022
Breaking the waves
John C Marioni, Natalie P Thorne, Armand Valsesia, Tomas Fitzgerald, Richard Redon, Heike Fiegler, T Daniel Andrews, Barbara E Stranger, Andrew G Lynch, Emmanouil T Dermitzakis, Nigel P Carter, Simon Tavaré, Matthew E Hurles
Jun 14, 2011
Targets downstream of Cdk8 in Dictyostelium development.
dsRNA sensing miR-155 microRNA microRNA mimics siRNA Apoptosis Cell Line Tumor Cell Proliferation Epithelial Cells Female Gene Expression Regulation Neoplastic Humans Interferon-beta Mammary Glands Human MicroRNAs Microarray Analysis Molecular Mimicry Organ Specificity Poly I-C RNA Double-Stranded RNA Small Interfering Signal Transduction Structure-Activity Relationship
Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer.
Alacoque L Browne, Sara Charmsaz, Damir Varešlija, Ailis Fagan, Nicola Cosgrove, Sinéad Cocchiglia, Siobhan Purcell, Elspeth Ward, Fiona Bane, Lance Hudson, Arnold D Hill, Jason S Carroll, Aisling M Redmond, Leonie S Young
Feb 22, 2019
Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and...
Animals Antineoplastic Agents Hormonal Breast Neoplasms Chromatin Assembly and Disassembly Drug Resistance Neoplasm Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Humans MCF-7 Cells Mice Mice Inbred NOD Mice SCID Microarray Analysis Nuclear Receptor Coactivator 1 Transcriptional Activation Transcriptome Tumor Cells Cultured
Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2.
A Reghan Foley, Manoj P Menezes, Amelie Pandraud, Michael A Gonzalez, Ahmad Al-Odaib, Alexander J Abrams, Kumiko Sugano, Atsushi Yonezawa, Adnan Y Manzur, Joshua Burns, Imelda Hughes, B Gary McCullagh, Heinz Jungbluth, Ming J Lim, Jean-Pierre Lin, Andre Megarbane, J Andoni Urtizberea, Ayaz H Shah, Jayne Antony, Richard Webster, Alexander Broomfield, Joanne Ng, Ann A Mathew, James J O'Byrne, Eva Forman, Mariacristina Scoto, Manish Prasad, Katherine O'Brien, Simon Olpin, Marcus Oppenheim, Iain Hargreaves, John M Land, Min X Wang, Kevin Carpenter, Rita Horvath, Volker Straub, Monkol Lek, Wendy Gold, Michael O Farrell, Sebastian Brandner, Rahul Phadke, Kazuo Matsubara, Michael L McGarvey, Steven S Scherer, Peter S Baxter, Mary D King, Peter Clayton, Shamima Rahman, Mary M Reilly, Robert A Ouvrier, John Christodoulou, Stephan Züchner, Francesco Muntoni, Henry Houlden
Mar 07, 2019
Childhood onset motor neuron diseases or neuronopathies are a clinically heterogeneous group of disorders. A particularly severe subgroup first described in 1894, and subsequently called Brown-Vialetto-Van Laere syndrome, is...
Brown-Vialetto-Van Laere syndrome RFVT2 SLC52A2 childhood neuronopathy riboflavin therapy Adolescent Brain Bulbar Palsy Progressive Carnitine Child Child Preschool Exome Female Genotype Hearing Loss Sensorineural Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Microarray Analysis motor neuron disease Mutation Neurologic Examination Pedigree RNA Receptors G-Protein-Coupled Riboflavin Sequence Analysis DNA Sural Nerve Vitamins Young Adult
Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.
JLL Robinson, TE Hickey, AY Warren, SL Vowler, T Carroll, AD Lamb, N Papoutsoglou, DE Neal, WD Tilley, JS Carroll
May 02, 2019
Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR)...
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans.
Optimized design and assessment of whole genome tiling arrays.
Stefan Gräf, Fiona GG Nielsen, Stefan Kurtz, Martijn A Huynen, Ewan Birney, Henk Stunnenberg, Paul Flicek
Sep 23, 2019
MOTIVATION: Recent advances in microarray technologies have made it feasible to interrogate whole genomes with tiling arrays and this technique is rapidly becoming one of the most important high-throughput functional genomics...
Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson's disease
BACKGROUND: As the popularity of transcriptomic analysis has grown, the reported lack of concordance between different studies of the same condition has become a growing concern, raising questions as to the representativeness of...
BRCA1-like signature in triple negative breast cancer
Tesa M Severson, Justine Peeters, Ian Majewski, Magali Michaut, Astrid Bosma, Philip C Schouten, Suet-Feung Chin, Bernard Pereira, Mae A Goldgraben, Tycho Bismeijer, Roelof JC Kluin, Jettie JF Muris, Karin Jirström, Ron M Kerkhoven, Lodewyk Wessels, Carlos Caldas, René Bernards, Iris M Simon, Sabine Linn
Jul 05, 2018
Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10-15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination-mediated DNA repair and deficiency...
BRCA1 Breast Cancer Genomic Instability targeted therapy Triple negative breast cancer Adult Aged Aged 80 and over Comparative Genomic Hybridization DNA Methylation DNA Mutational Analysis Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genes BRCA1 High-Throughput Nucleotide Sequencing Humans Microarray Analysis Middle Aged Molecular Targeted Therapy Promoter Regions Genetic Transcriptome Triple Negative Breast Neoplasms
CNVs affecting cancer predisposing genes (CPGs) detected as incidental findings in routine germline diagnostic chromosomal microarray (CMA) testing.
Josie Innes, Lisa Reali, Jill Clayton-Smith, Georgina Hall, Derek Hk Lim, George J Burghel, Kim French, Unzela Khan, Daniel Walker, Fiona Lalloo, D Gareth R Evans, Dominic McMullan, Eamonn R Maher, Emma R Woodward
Jan 17, 2018
BACKGROUND: Identification of CNVs through chromosomal microarray (CMA) testing is the first-line investigation in individuals with learning difficulties/congenital abnormalities. Although recognised that CMA testing may...
copy-number Genetic screening/counselling Genetics microarray Bone Morphogenetic Protein Receptors Type I Child Preschool Chromosome Deletion Cohort Studies DNA Copy Number Variations Female Genetic Predisposition to Disease Humans Incidental Findings Infant Male Membrane Proteins Microarray Analysis Neoplasms Oncogenes Pilot Projects Proto-Oncogene Mas Tuberous Sclerosis Complex 2 Protein
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
Ana Monteagudo-Sánchez, Jose Ramon Hernandez Mora, Carlos Simon, Adam Burton, Jair Tenorio, Pablo Lapunzina, Stephen Clark, Manel Esteller, Gavin Kelsey, Juan Pedro López-Siguero, Guiomar Perez de Nanclares, Maria-Elena Torres-Padilla, David Monk
Jan 11, 2021
Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific monoallelic gene expression. A subset of individuals...
Beckwith-Wiedemann syndrome Cohort Studies DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Embryo Mammalian Genomic Imprinting Germ Cells Humans Microarray Analysis Mutation Oocytes Pedigree pseudohypoparathyroidism RNA-seq Repressor Proteins Siblings Transcriptome Tripartite Motif-Containing Protein 28
Identification of peculiar gene expression profile in peripheral blood mononuclear cells (PBMC) of celiac patients on gluten free diet.
Moris Sangineto, Giusi Graziano, Simona D'Amore, Roberto Salvia, Giuseppe Palasciano, Carlo Sabbà, Michele Vacca, Marica Cariello
Sep 20, 2018
Celiac disease (CD) is a systemic disorder characterized by an immune-mediated reaction to gluten and a wide spectrum of clinical manifestations. Currently, the main treatment of CD is represented by adherence to a gluten-free...
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Georg B Ehret, Teresa Ferreira, Daniel I Chasman, Anne U Jackson, Ellen M Schmidt, Toby Johnson, Gudmar Thorleifsson, Jian'an Luan, Lousie A Donnelly, Stavroula Kanoni, Ann-Kristin Petersen, Vasyl Pihur, Rona J Strawbridge, Dmitry Shungin, Maria F Hughes, Osorio Meirelles, Marika Kaakinen, Nabila Bouatia-Naji, Kati Kristiansson, Sonia Shah, Marcus E Kleber, Xiuqing Guo, Leo-Pekka Lyytikäinen, Cristiano Fava, Niclas Eriksson, Ilja M Nolte, Patrik K Magnusson, Elias L Salfati, Loukianos S Rallidis, Elizabeth Theusch, Andrew JP Smith, Lasse Folkersen, Kate Witkowska, Tune H Pers, Roby Joehanes, Stuart K Kim, Lazaros Lataniotis, Rick Jansen, Andrew D Johnson, Helen Warren, Young Jin Kim, Wei Zhao, Ying Wu, Bamidele O Tayo, Murielle Bochud, CHARGE-EchoGen consortium, CHARGE-HF consortium, Wellcome Trust Case Control Consortium, Devin Absher, Linda S Adair, Najaf Amin, Dan E Arking, Tomas Axelsson, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Michael R Barnes, Inês Barroso, Stephen Bevan, Joshua C Bis, Gyda Bjornsdottir, Michael Boehnke, Eric Boerwinkle, Lori L Bonnycastle, Dorret I Boomsma, Stefan R Bornstein, Morris J Brown, Michel Burnier, Claudia P Cabrera, John C Chambers, I-Shou Chang, Ching-Yu Cheng, Peter S Chines, Ren-Hua Chung, Francis S Collins, John M Connell, Angela Döring, Jean Dallongeville, John Danesh, Ulf de Faire, Graciela Delgado, Anna F Dominiczak, Alex SF Doney, Fotios Drenos, Sarah Edkins, John D Eicher, Roberto Elosua, Stefan Enroth, Jeanette Erdmann, Per Eriksson, Tonu Esko, Evangelos Evangelou, Alun Evans, Tove Fall, Martin Farrall, Janine F Felix, Jean Ferrières, Luigi Ferrucci, Myriam Fornage, Terrence Forrester, Nora Franceschini, Oscar H Franco Duran, Anders Franco-Cereceda, Ross M Fraser, Santhi K Ganesh, He Gao, Karl Gertow, Francesco Gianfagna, Bruna Gigante, Franco Giulianini, Anuj Goel, Alison H Goodall, Mark O Goodarzi, Mathias Gorski, Jürgen Gräßler, Christopher Groves, Vilmundur Gudnason, Ulf Gyllensten, Göran Hallmans, Anna-Liisa Hartikainen, Maija Hassinen, Aki S Havulinna, Caroline Hayward, Serge Hercberg, Karl-Heinz Herzig, Andrew A Hicks, Aroon D Hingorani, Joel N Hirschhorn, Albert Hofman, Jostein Holmen, Oddgeir Lingaas Holmen, Jouke-Jan Hottenga, Phil Howard, Chao A Hsiung, Steven C Hunt, M Arfan Ikram, Thomas Illig, Carlos Iribarren, Richard A Jensen, Mika Kähönen, Hyun Kang, Sekar Kathiresan, Brendan J Keating, Kay-Tee Khaw, Yun Kyoung Kim, Eric Kim, Mika Kivimaki, Norman Klopp, Genovefa Kolovou, Pirjo Komulainen, Jaspal S Kooner, Gulum Kosova, Ronald M Krauss, Diana Kuh, Zoltan Kutalik, Johanna Kuusisto, Kirsti Kvaløy, Timo A Lakka, Nanette R Lee, I-Te Lee, Wen-Jane Lee, Daniel Levy, Xiaohui Li, Kae-Woei Liang, Honghuang Lin, Li Lin, Jaana Lindström, Stéphane Lobbens, Satu Männistö, Gabriele Müller, Martina Müller-Nurasyid, François Mach, Hugh S Markus, Eirini Marouli, Mark I McCarthy, Colin A McKenzie, Pierre Meneton, Cristina Menni, Andres Metspalu, Vladan Mijatovic, Leena Moilanen, May E Montasser, Andrew D Morris, Alanna C Morrison, Antonella Mulas, Ramaiah Nagaraja, Narisu Narisu, Kjell Nikus, Christopher J O'Donnell, Paul F O'Reilly, Ken K Ong, Fred Paccaud, Cameron D Palmer, Afshin Parsa, Nancy L Pedersen, Brenda W Penninx, Markus Perola, Annette Peters, Neil Poulter, Peter P Pramstaller, Bruce M Psaty, Thomas Quertermous, Dabeeru C Rao, Asif Rasheed, N William NWR Rayner, Frida Renström, Rainer Rettig, Kenneth M Rice, Robert Roberts, Lynda M Rose, Jacques Rossouw, Nilesh J Samani, Serena Sanna, Jouko Saramies, Heribert Schunkert, Sylvain Sebert, Wayne H-H Sheu, Young-Ah Shin, Xueling Sim, Johannes H Smit, Albert V Smith, Maria X Sosa, Tim D Spector, Alena Stančáková, Alice Stanton, Kathleen E Stirrups, Heather M Stringham, Johan Sundstrom, Amy J Swift, Ann-Christine Syvänen, E-Shyong Tai, Toshiko Tanaka, Kirill V Tarasov, Alexander Teumer, Unnur Thorsteinsdottir, Martin D Tobin, Elena Tremoli, Andre G Uitterlinden, Matti Uusitupa, Ahmad Vaez, Dhananjay Vaidya, Cornelia M van Duijn, Erik PA van Iperen, Ramachandran S Vasan, Germaine C Verwoert, Jarmo Virtamo, Veronique Vitart, Benjamin F Voight, Peter Vollenweider, Aline Wagner, Louise V Wain, Nicholas J Wareham, Hugh Watkins, Alan B Weder, Harm-Jan Westra, Rainford Wilks, Tom Wilsgaard, James F Wilson, Tien Y Wong, Tsun-Po Yang, Jie Yao, Loic Yengo, Weihua Zhang, Jing Hua Zhao, Xiaofeng Zhu, Pascal Bovet, Richard S Cooper, Karen L Mohlke, Danish Saleheen, Jong-Young Lee, Paul Elliott, Hinco J Gierman, Cristen J Willer, Lude Franke, G Kees Hovingh, Kent D Taylor, George Dedoussis, Peter Sever, Andrew Wong, Lars Lind, Themistocles L Assimes, Inger Njølstad, Peter Eh Schwarz, Claudia Langenberg, Harold Snieder, Mark J Caulfield, Olle Melander, Markku Laakso, Juha Saltevo, Rainer Rauramaa, Jaakko Tuomilehto, Erik Ingelsson, Terho Lehtimäki, Kristian Hveem, Walter Palmas, Winfried März, Meena Kumari, Veikko Salomaa, Yii-Der I Chen, Jerome I Rotter, Philippe Froguel, Marjo-Riitta Jarvelin, Edward G Lakatta, Kari Kuulasmaa, Paul W Franks, Anders Hamsten, H-Erich Wichmann, Colin NA Palmer, Kari Stefansson, Paul M Ridker, Ruth JF Loos, Aravinda Chakravarti, Panos Deloukas, Andrew P Morris, Christopher Newton-Cheh, Patricia B Munroe
Nov 20, 2017
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an...
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