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A cell topography-based mechanism for ligand discrimination by the T cell receptor.
Ricardo A Fernandes, Kristina A Ganzinger, Justin C Tzou, Peter Jönsson, Steven F Lee, Matthieu Palayret, Ana Mafalda Santos, Alexander R Carr, Aleks Ponjavic, Veronica T Chang, Charlotte Macleod, B Christoffer Lagerholm, Alan E Lindsay, Omer Dushek, Andreas Tilevik, Simon J Davis, David Klenerman
May 24, 2019
T cell receptor dwell time microvilli receptor triggering single-molecule imaging Animals Antigen-Presenting Cells Host-Pathogen Interactions Humans Immunity Innate Kinetics Ligands Lymphocyte Activation Major Histocompatibility Complex Microvilli Models Theoretical Peptides Phosphorylation Receptors Antigen T-Cell Signal Transduction single molecule imaging T-Lymphocytes