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Results: 3578
Effect of snack-food proximity on intake in general population samples with higher and lower cognitive resource.
OBJECTIVE: Placing snack-food further away from people consistently decreases its consumption ("proximity effect"). However, given diet-related health inequalities, it is important to know whether interventions that alter food...
Age-related functional reorganization, structural changes, and preserved cognition.
Although healthy aging is associated with general cognitive decline, there is considerable variability in the extent to which cognitive functions decline or are preserved. Preserved cognitive function in the context of...
Responses to provision of personalised cancer risk information
Juliet Usher-Smith, Barbora Silarova, Artitaya Lophatananon, Robbie Duschinsky, Jackie Campbell, Joanne Warcaba, Kenneth Muir
Feb 16, 2018
Background
It is estimated that nearly 600,000 cancer cases in the UK could have been avoided in the past five years if people had healthier lifestyles. A number of theories of behaviour change suggest that before people will...
Critical Thresholds of Intracranial Pressure-Derived Continuous Cerebrovascular Reactivity Indices for Outcome Prediction in Noncraniectomized Patients with Traumatic Brain Injury.
Frederick A Zeiler, Joseph Donnelly, Peter Smielewski, David K Menon, Peter J Hutchinson, Marek Czosnyka
Feb 19, 2018
The aim of the study was to compare intracranial pressure (ICP)-derived cerebrovascular reactivity indices in their ability to predict six-month outcome, and to determine/compare critical thresholds related to outcome for each...
Online news media reporting of football-related fatalities in Australia
OBJECTIVES: While deaths in sports settings are rare, they do occur. To develop an understanding of the sports and people most at risk, and to identify opportunities for prevention, routine and systematic data detailing the...
Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS)
Philip M Bath, Lisa J Woodhouse, Jason P Appleton, Maia Beridze, Hanne Christensen, Robert A Dineen, Lelia Duley, Timothy J England, Katie Flaherty, Diane Havard, Stan Heptinstall, Marilyn James, Kailash Krishnan, Hugh S Markus, Alan A Montgomery, Stuart J Pocock, Marc Randall, Annemarei Ranta, Thompson G Robinson, Polly Scutt, Graham S Venables, Nikola Sprigg, TARDIS Investigators
Mar 07, 2018
BACKGROUND: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy...
Acute Disease Aged Aspirin Brain Ischemia Clopidogrel Denmark Dipyridamole Drug Therapy Combination Female Georgia Hemorrhage Humans Ischemia Ischemic Attack Transient Male Middle Aged New Zealand Platelet Aggregation Inhibitors Prospective Studies Recurrence Research Design Risk Assessment stroke Thrombolytic Therapy Ticlopidine Treatment Outcome United Kingdom
Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives
Fabio Girardi, Daniel R Barnes, Daniel Barrowdale, Debra Frost, Angela F Brady, Claire Miller, Alex Henderson, Alan Donaldson, Alex Murray, Carole Brewer, Caroline Pottinger, D Gareth Evans, Diana Eccles, EMBRACE, Fiona Lalloo, Helen Gregory, Jackie Cook, Jacqueline Eason, Julian Adlard, Julian Barwell, Kai Ren Ong, Lisa Walker, Louise Izatt, Lucy E Side, M John Kennedy, Marc Tischkowitz, Mark T Rogers, Mary E Porteous, Patrick J Morrison, Ros Eeles, Rosemarie Davidson, Katie Snape, Douglas F Easton, Antonis C Antoniou
Mar 16, 2018
PURPOSE: BRCA1/BRCA2 predictive test negatives are proven noncarriers of a BRCA1/BRCA2 mutation that is carried by their relatives. The risk of developing breast cancer (BC) or epithelial ovarian cancer (EOC) in these women is...
Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI).
Henri JMM Mutsaerts, Jan Petr, David L Thomas, Enrico De Vita, David M Cash, Matthias JP van Osch, Xavier Golay, Paul FC Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Francesca B Pizzini, Elizabeth Finger, Sandro Sorbi, Miguel Castelo Branco, Jonathan D Rohrer, Mario Masellis, Bradley J MacIntosh, GENFI investigators
Mar 22, 2018
PURPOSE: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. MATERIALS AND...
arterial spin labeling cerebral blood flow image registration Adult arteries Brain Cerebrovascular Circulation Female frontotemporal dementia Gray Matter Humans Image Processing Computer-Assisted Imaging Three-Dimensional Magnetic Resonance Imaging Male Middle Aged Perfusion Reproducibility of Results Spin Labels Young Adult
The devil's in the detail
Models of memory propose that separate systems underpin the storage and recollection of specific events from our past (e.g., the first day at school), and of the generic structure of our experiences (e.g., how lonely I am), and...
Circulating vitamin D concentrations and risk of breast and prostate cancer
Xia Jiang, Niki L Dimou, Kawthar Al-Dabhani, Sarah J Lewis, Richard M Martin, Philip C Haycock, Marc J Gunter, Timothy J Key, Rosalind A Eeles, Kenneth Muir, David Neal, Graham G Giles, Edward L Giovannucci, Meir Stampfer, Brandon L Pierce, Joellen M Schildkraut, Shaneda Warren Andersen, Deborah Thompson, Wei Zheng, Peter Kraft, Konstantinos K Tsilidis, CRUK, BPC3, CAPS and PEGASUS consortia PRACTICAL
Apr 26, 2018
BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR)...
Mendelian randomization Breast malignancy Prostate serum vitamin D concentrations Aged Breast Neoplasms Causality Female Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Prostatic Neoplasms Receptors Estrogen Risk Factors vitamin D
Problematic internet use as an age-related multifaceted problem
Konstantinos Ioannidis, Matthias S Treder, Samuel R Chamberlain, Franz Kiraly, Sarah A Redden, Dan J Stein, Christine Lochner, Jon E Grant
May 02, 2018
BACKGROUND AND AIMS: Problematic internet use (PIU; otherwise known as Internet Addiction) is a growing problem in modern societies. There is scarce knowledge of the demographic variables and specific internet activities...
Behavioral addiction Internet addiction Internet gaming disorder LASSO Machine Learning Problematic internet use Adolescent Adult Age Factors Anxiety Disorders Attention Deficit Disorder with Hyperactivity Behavior Addictive Erotica Female Gambling Humans Internet Machine Learning Male Middle Aged Obsessive-Compulsive Disorder Online Social Networking Phobia Social principal component analysis Regression Analysis Sex Factors South Africa Surveys and Questionnaires United States Video Games Young Adult
Fear-of-falling and associated risk factors in persons with rheumatoid arthritis
Emma K Stanmore, Jackie Oldham, Dawn A Skelton, Terence O'Neill, Mark Pilling, Chris Todd
Feb 11, 2021
Effect of the Relative Timing between Same-Polarity Pulses on Thresholds and Loudness in Cochlear Implant Users.
The effect of the relative timing between pairs of same-polarity monophasic pulses has been studied extensively in single-neuron animal studies and has revealed fundamental properties of the neurons. For human cochlear implant...
Perspectives of Patients With Rheumatic Diseases in the Early Phase of COVID-19
Anna Antony, Kathryn Connelly, Thilinie De Silva, Laura Eades, William Tillett, Sally Ayoub, Eric Morand
Aug 31, 2020
OBJECTIVE: To determine health perceptions of patients with rheumatic diseases in the early phase of the coronavirus disease 2019 (COVID-19) pandemic.
METHODS: Rheumatology patients at a single center received via text...
Antirheumatic Agents/adverse effects Attitude to Health Betacoronavirus Coronavirus Infections/prevention & control Female Humans Male Medication Adherence Middle Aged Pandemics/prevention & control Patient Acceptance of Health Care/psychology Pneumonia Viral/prevention & control Rheumatic Diseases/drug therapy Severity of Illness Index Surveys and Questionnaires
Genetically raised serum bilirubin levels and lung cancer
BACKGROUND: Moderately raised serum bilirubin levels are associated with lower rates of lung cancer, particularly among smokers. It is not known whether these relationships reflect antioxidant properties or residual confounding....
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Sanne LN Brouns, Johanna P van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W Farndale, Kenneth J Clemetson, Henri MH Spronk, Paola EJ van der Meijden, Rachel Cavill, Marijke JE Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan WM Heemskerk
Sep 09, 2020
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet...
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P Tyrer, Manjeet K Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H Wu, Daniel O Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L Chan, Su Ming Tan, Jaime Seah, Esther M John, Allison W Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J Spinelli, Kristan J Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul DP Pharoah, Wei Zheng, Alison M Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F Easton, Soo-Hwang Teo, Antonis C Antoniou
Sep 09, 2020
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from...
Modeling arterial pulse waves in healthy aging
Peter H Charlton, Jorge Mariscal Harana, Samuel Vennin, Ye Li, Phil Chowienczyk, Jordi Alastruey
Sep 11, 2020
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It is widely measured by both consumer and clinical devices. However, the physical determinants of the PW are not yet fully understood...
Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE)
Steven Bell, Michael Sweeting, Anna Ramond, Ryan Chung, Stephen Kaptoge, Matthew Walker, Thomas Bolton, Jennifer Sambrook, Carmel Moore, Amy McMahon, Sarah Fahle, Donna Cullen, Susan Mehenny, Angela M Wood, Jane Armitage, Willem H Ouwehand, Gail Miflin, David J Roberts, John Danesh, Emanuele Di Angelantonio, COMPARE Study Group
Jan 04, 2021
OBJECTIVE: To compare four haemoglobin measurement methods in whole blood donors. BACKGROUND: To safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant's (NHSBT)...
HemoCue gravimetry haemoglobin screening inappropriate bleeding inappropriate deferral non-invasive haemoglobin measurement whole blood donor Adolescent Adult Aged Aged 80 and over Anemia Biomarkers Blood Donors Cross-Over Studies Donor Selection Female Hemoglobinometry Hemoglobins Humans Male Middle Aged Reference Standards Sensitivity and Specificity Spectrophotometry Young Adult
Fulminant corticobasal degeneration
Helen Ling, Ellen Gelpi, Karen Davey, Zane Jaunmuktane, Kin Y Mok, Edwin Jabbari, Roberto Simone, Lea R'Bibo, Sebastian Brandner, Matthew J Ellis, Johannes Attems, David Mann, Glenda M Halliday, S Al-Sarraj, J Hedreen, James W Ironside, Gabor G Kovacs, E Kovari, S Love, Jean Paul G Vonsattel, Kieren SJ Allinson, Daniela Hansen, Teisha Bradshaw, Núria Setó-Salvia, Selina Wray, Rohan de Silva, Huw R Morris, Thomas T Warner, John Hardy, Janice L Holton, Tamas Revesz
Jan 15, 2021
Corticobasal degeneration typically progresses gradually over 5-7 years from onset till death. Fulminant corticobasal degeneration cases with a rapidly progressive course were rarely reported (RP-CBD). This study aimed to...
Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes
E-M Dalsgaard, A Sandbaek, SJ Griffin, GEHM Rutten, K Khunti, MJ Davies, GJ Irving, RC Vos, DR Webb, NJ Wareham, DR Witte
Jul 29, 2020
AIMS: To present the longer-term impact of multifactorial treatment of type 2 diabetes on self-reported health status, diabetes-specific quality of life, and diabetes treatment satisfaction at 10-year follow up of the...
A Highly Tailored Text and Voice Messaging Intervention to Improve Medication Adherence in Patients With Either or Both Hypertension and Type 2 Diabetes in a UK Primary Care Setting
Aikaterini Kassavou, Venus Mirzaei, James Brimicombe, Simon Edwards, Efthalia Massou, A Toby Prevost, Simon Griffin, Stephen Sutton
Aug 03, 2020
BACKGROUND: The efficacy of a highly tailored digital intervention to support medication adherence and feasibility to support clinical effectiveness as an adjunct to the primary care setting has not been evaluated. OBJECTIVE...
Hypertension interactive voice response Medication Adherence Text Messaging Type 2 diabetes Adolescent Adult Aged Aged 80 and over Diabetes mellitus Type 2 Feasibility Studies Female Humans Hypertension Male Medication Adherence Middle Aged Quality of life Text Messaging Treatment Outcome United Kingdom Young Adult
Comparative effectiveness of cognitive therapies delivered face-to-face or over the telephone
Geoffrey C Hammond, Tim J Croudace, Muralikrishnan Radhakrishnan, Louise Lafortune, Alison Watson, Fiona McMillan-Shields, Peter B Jones
Aug 05, 2020
OBJECTIVES: To compare the clinical and cost-effectiveness of face-to-face (FTF) with over-the-telephone (OTT) delivery of low intensity cognitive behavioural therapy. DESIGN: Observational study following SROBE guidelines....
The Effects of Trabecular Bypass Surgery on Conventional Aqueous Outflow, Visualized by Hemoglobin Video Imaging.
Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease
Calum A Hamilton, Fiona E Matthews, Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Jim Lloyd, George Petrides, Ian G McKeith, Alan J Thomas
Aug 07, 2020
OBJECTIVE: We explored whether the mild cognitive impairment (MCI) stages of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) differ in their cognitive profiles, and longitudinal progression. DESIGN: A prospective...
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