Search
Results: 3578
Mapping traumatic axonal injury using diffusion tensor imaging
Virginia Newcombe, Doris Chatfield, Joanne Outtrim, Sarah Vowler, Anne Manktelow, Justin Cross, Daniel Scoffings, Martin Coleman, Peter Hutchinson, Jonathan Coles, T Adrian Carpenter, John Pickard, Guy Williams, David Menon
Dec 04, 2018
BACKGROUND: Traumatic brain injury is a major cause of morbidity and mortality worldwide. Ameliorating the neurocognitive and physical deficits that accompany traumatic brain injury would be of substantial benefit, but the...
Somatic mutant clones colonize the human esophagus with age.
Iñigo Martincorena, Joanna C Fowler, Agnieszka Wabik, Andrew RJ Lawson, Federico Abascal, Michael WJ Hall, Alex Cagan, Kasumi Murai, Krishnaa Mahbubani, Michael R Stratton, Rebecca C Fitzgerald, Penny A Handford, Peter J Campbell, Kourosh Saeb-Parsy, Philip H Jones
Dec 06, 2018
Association of thirty-year alcohol consumption typologies and fatty liver
Anticipatory prescribing of injectable medications for adults at the end of life in the community
Anticipatory prescribing DEATH Palliative Care Palliative Medicine palliative medicine kit Review Systematic review Terminal Care Adult Aged Aged 80 and over Cohort Studies Drug Prescriptions Female Humans Injections Male Middle Aged Palliative Care Pilot Projects Prescription Drugs qualitative research Retrospective Studies Terminal Care
Structural correlates of cognitive impairment in normal pressure hydrocephalus.
Katie A Peterson, Tom B Mole, Nicole CH Keong, Elise E DeVito, George Savulich, John D Pickard, Barbara J Sahakian
Dec 14, 2018
Repeatability of diffusion-weighted MRI of the prostate using whole lesion ADC values, skew and histogram analysis.
Tristan Barrett, Edward M Lawrence, Andrew N Priest, Anne Y Warren, Vincent J Gnanapragasam, Ferdia A Gallagher, Evis Sala
Dec 14, 2018
PURPOSE: To investigate the repeatability of diffusion-weighted imaging parameter including ADC-derived histogram values in prostate cancer. METHODS: 10 patients with prostate cancer were prospectively recruited to a retest...
Integrative Molecular Characterization of Malignant Pleural Mesothelioma.
Julija Hmeljak, Francisco Sanchez-Vega, Katherine A Hoadley, Juliann Shih, Chip Stewart, David Heiman, Patrick Tarpey, Ludmila Danilova, Esther Drill, Ewan A Gibb, Reanne Bowlby, Rupa Kanchi, Hatice U Osmanbeyoglu, Yoshitaka Sekido, Jumpei Takeshita, Yulia Newton, Kiley Graim, Manaswi Gupta, Carl M Gay, Lixia Diao, David L Gibbs, Vesteinn Thorsson, Lisa Iype, Havish Kantheti, David T Severson, Gloria Ravegnini, Patrice Desmeules, Achim A Jungbluth, William D Travis, Sanja Dacic, Lucian R Chirieac, Françoise Galateau-Sallé, Junya Fujimoto, Aliya N Husain, Henrique C Silveira, Valerie W Rusch, Robert C Rintoul, Harvey Pass, Hedy Kindler, Marjorie G Zauderer, David J Kwiatkowski, Raphael Bueno, Anne S Tsao, Jenette Creaney, Tara Lichtenberg, Kristen Leraas, Jay Bowen, TCGA Research Network, Ina Felau, Jean Claude Zenklusen, Rehan Akbani, Andrew D Cherniack, Lauren A Byers, Michael S Noble, Jonathan A Fletcher, A Gordon Robertson, Ronglai Shen, Hiroyuki Aburatani, Bruce W Robinson, Peter Campbell, Marc Ladanyi
Dec 17, 2018
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of...
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
A Simple Ultrasound Based Classification Algorithm Allows Differentiation of Benign from Malignant Breast Lesions by Using Only Quantitative Parameters.
Panagiotis Kapetas, Ramona Woitek, Paola Clauser, Maria Bernathova, Katja Pinker, Thomas H Helbich, Pascal A Baltzer
Dec 20, 2018
PURPOSE: We hypothesized that different quantitative ultrasound (US) parameters may be used as complementary diagnostic criteria and aimed to develop a simple classification algorithm to distinguish benign from malignant breast...
CT colonography
Christian Bräuer, Philippe Lefere, Stefaan Gryspeerdt, Helmut Ringl, Ali Al-Mukhtar, Paul Apfaltrer, Dominik Berzaczy, Barbara Füger, Julia Furtner, Christina Müller-Mang, Matthias Pones, Martina Scharitzer, Ramona Woitek, Anno Graser, Michael Weber, Thomas Mang
Dec 20, 2018
OBJECTIVES: To assess whether electronic cleansing (EC) of tagged residue and different computed tomography (CT) windows influence the size of colorectal polyps in CT colonography (CTC). METHODS: A database of 894...
CT colonography Cancer screening Colonic Polyps Neoplasms colorectal Virtual colonoscopy Aged Algorithms Analysis of Variance Colonic Polyps Colonography Computed Tomographic Female Humans Image Processing Computer-Assisted Male Middle Aged Reference Standards Retrospective Studies Sensitivity and Specificity
Preoperative staging using magnetic resonance imaging and risk of positive surgical margins after prostate-cancer surgery.
Fredrik Jäderling, Olof Akre, Markus Aly, Johan Björklund, Mats Olsson, Christofer Adding, Michael Öberg, Lennart Blomqvist, Tommy Nyberg, Peter Wiklund, Stefan Carlsson
Dec 21, 2018
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
Satish Patel, Anna Alvarez-Guaita, Audrey Melvin, Debra Rimmington, Alessia Dattilo, Emily L Miedzybrodzka, Irene Cimino, Anne-Catherine Maurin, Geoffrey P Roberts, Claire L Meek, Samuel Virtue, Lauren M Sparks, Stephanie A Parsons, Leanne M Redman, George A Bray, Alice P Liou, Rachel M Woods, Sion A Parry, Per B Jeppesen, Anders J Kolnes, Heather P Harding, David Ron, Antonio Vidal-Puig, Frank Reimann, Fiona M Gribble, Carl J Hulston, I Sadaf Farooqi, Pierre Fafournoux, Steven R Smith, Jorgen Jensen, Danna Breen, Zhidan Wu, Bei B Zhang, Anthony P Coll, David B Savage, Stephen O'Rahilly
Dec 21, 2018
Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI).
Henri JMM Mutsaerts, Jan Petr, David L Thomas, Enrico De Vita, David M Cash, Matthias JP van Osch, Xavier Golay, Paul FC Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Francesca B Pizzini, Elizabeth Finger, Sandro Sorbi, Miguel Castelo Branco, Jonathan D Rohrer, Mario Masellis, Bradley J MacIntosh, GENFI investigators
Mar 22, 2018
PURPOSE: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. MATERIALS AND...
arterial spin labeling cerebral blood flow image registration Adult arteries Brain Cerebrovascular Circulation Female frontotemporal dementia Gray Matter Humans Image Processing Computer-Assisted Imaging Three-Dimensional Magnetic Resonance Imaging Male Middle Aged Perfusion Reproducibility of Results Spin Labels Young Adult
The devil's in the detail
Models of memory propose that separate systems underpin the storage and recollection of specific events from our past (e.g., the first day at school), and of the generic structure of our experiences (e.g., how lonely I am), and...
Circulating vitamin D concentrations and risk of breast and prostate cancer
Xia Jiang, Niki L Dimou, Kawthar Al-Dabhani, Sarah J Lewis, Richard M Martin, Philip C Haycock, Marc J Gunter, Timothy J Key, Rosalind A Eeles, Kenneth Muir, David Neal, Graham G Giles, Edward L Giovannucci, Meir Stampfer, Brandon L Pierce, Joellen M Schildkraut, Shaneda Warren Andersen, Deborah Thompson, Wei Zheng, Peter Kraft, Konstantinos K Tsilidis, CRUK, BPC3, CAPS and PEGASUS consortia PRACTICAL
Apr 26, 2018
BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR)...
Mendelian randomization Breast malignancy Prostate serum vitamin D concentrations Aged Breast Neoplasms Causality Female Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Prostatic Neoplasms Receptors Estrogen Risk Factors vitamin D
Problematic internet use as an age-related multifaceted problem
Konstantinos Ioannidis, Matthias S Treder, Samuel R Chamberlain, Franz Kiraly, Sarah A Redden, Dan J Stein, Christine Lochner, Jon E Grant
May 02, 2018
BACKGROUND AND AIMS: Problematic internet use (PIU; otherwise known as Internet Addiction) is a growing problem in modern societies. There is scarce knowledge of the demographic variables and specific internet activities...
Behavioral addiction Internet addiction Internet gaming disorder LASSO Machine Learning Problematic internet use Adolescent Adult Age Factors Anxiety Disorders Attention Deficit Disorder with Hyperactivity Behavior Addictive Erotica Female Gambling Humans Internet Machine Learning Male Middle Aged Obsessive-Compulsive Disorder Online Social Networking Phobia Social principal component analysis Regression Analysis Sex Factors South Africa Surveys and Questionnaires United States Video Games Young Adult
Daytime napping and the risk of all-cause and cause-specific mortality
Yue Leng, Nick WJ Wainwright, Francesco P Cappuccio, Paul G Surtees, Shabina Hayat, Robert Luben, Carol Brayne, Kay-Tee Khaw
Sep 21, 2018
aging Mortality Napping Respiratory siesta Sleep Survival Analysis Adult Age Factors Aged Body Mass Index Cardiovascular Diseases Female Health Behavior Health Surveys Humans Male Middle Aged Mortality Prospective Studies Respiratory Tract Diseases Risk Assessment Sleep Socioeconomic Factors Time Factors United Kingdom
Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.
Anna L Godfrey, Peter J Campbell, Cathy MacLean, Georgina Buck, Julia Cook, Julie Temple, Bridget S Wilkins, Keith Wheatley, Jyoti Nangalia, Jacob Grinfeld, Mary Frances McMullin, Cecily Forsyth, Jean-Jacques Kiladjian, Anthony R Green, Claire N Harrison, United Kingdom Medical Research Council Primary Thrombocythemia-1 Study, United Kingdom National Cancer Research Institute Myeloproliferative Neoplasms Subgroup, French Intergroup of Myeloproliferative Neoplasms, the Australasian Leukaemia and Lymphoma Group.
Sep 29, 2018
Adult Aspirin Australia Disease Progression Dose-Response Relationship Drug Drug Administration Schedule Drug Therapy Combination Female France Humans Hydroxyurea Internationality Ireland Janus Kinase 2 Kaplan-Meier Estimate Male Middle Aged New Zealand Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Severity of Illness Index Thrombocythemia Essential Thrombosis Treatment Outcome United Kingdom
Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study
Robert Scragg, Alistair W Stewart, Debbie Waayer, Carlene MM Lawes, Les Toop, John Sluyter, Judy Murphy, Kay-Tee Khaw, Carlos A Camargo
Oct 03, 2018
Aged Aged 80 and over Angina Pectoris Arrhythmias Cardiac arteriosclerosis Cardiovascular Diseases Cholecalciferol Dietary Supplements Double-Blind Method Female Heart Failure Humans Hypertension Male Middle Aged Myocardial Infarction New Zealand Proportional Hazards Models stroke venous thrombosis Vitamin D Deficiency Vitamins
Safety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients.
Wladyslaw Januszewicz, Wei Keith Tan, Katie Lehovsky, Irene Debiram-Beecham, Tara Nuckcheddy, Susan Moist, Sudarshan Kadri, Massimiliano di Pietro, Alex Boussioutas, Nicholas J Shaheen, David A Katzka, Evan S Dellon, Rebecca C Fitzgerald, BEST1 and BEST2 study investigators
Oct 03, 2018
BACKGROUND & AIMS: Diagnosis and surveillance of Barrett's esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge is a novel, minimally invasive esophageal cell collection device....
Acceptability of Healthcare Medical device Safety Aged Barrett Esophagus Cytological Techniques Eosinophilic Esophagitis Equipment and Supplies Female Humans Male Mass Screening Middle Aged Patient Acceptance of Health Care Patient Safety Prospective Studies Retrospective Studies Risk Factors Specimen Handling
Exploring rare and low-frequency variants in the Saguenay-Lac-Saint-Jean population identified genes associated with asthma and allergy traits.
Andréanne Morin, Anne-Marie Madore, Tony Kwan, Maria Ban, Jukka Partanen, Lars Rönnblom, Ann-Christine Syvänen, Stephen Sawcer, Hendrik Stunnenberg, Mark Lathrop, Tomi Pastinen, Catherine Laprise
Oct 03, 2018
The Saguenay-Lac-Saint-Jean (SLSJ) region is located in northeastern Quebec and is known for its unique demographic history and founder effect. As founder populations are enriched with population-specific variants, we...
Adolescent Adult Aged Aged 80 and over Asthma Child Child Preschool DNA-Binding Proteins Female Gene Frequency Humans Male Microtubule-Associated Proteins Middle Aged Mitochondrial Proteins Neuropilin-2 Polymorphism Single Nucleotide Quebec Receptors CXCR6 Ribosomal Proteins Serpin E2 Transcription Factors
Missed opportunities in prevention of cardiovascular disease in primary care
Antihypertensive Agents Primary Health Care Primary Prevention risk Secondary Prevention Statins Adult Aged Antihypertensive Agents Cardiovascular Diseases Cross-Sectional Studies Early Diagnosis Female General Practice Guideline Adherence Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Practice Guidelines as Topic Primary Prevention Retrospective Studies Risk Assessment United Kingdom Young Adult
Individual prognosis at diagnosis in nonmetastatic prostate cancer
David R Thurtle, David C Greenberg, Lui S Lee, Hong H Huang, Paul D Pharoah, Vincent J Gnanapragasam
Feb 18, 2019
Invasive Non-typhoidal Salmonella Infections in Asia
Nguyen Phu Huong Lan, Tu Le Thi Phuong, Hien Nguyen Huu, Le Thuy, Alison E Mather, Se Eun Park, Florian Marks, Guy E Thwaites, Nguyen Van Vinh Chau, Corinne N Thompson, Stephen Baker
Feb 19, 2019
Invasive non-typhoidal Salmonella (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations...
Adult Aged Anti-Infective Agents Ceftriaxone Drug Therapy Combination Female Fluoroquinolones HIV Infections Hospitals Humans Logistic Models Male Middle Aged Multilocus Sequence Typing Multivariate Analysis Retrospective Studies Salmonella Infections Salmonella enterica Serogroup Sex Factors Trimethoprim Sulfamethoxazole Drug Combination Typhoid Fever Vietnam
|
|< |
< |
1 |