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OBJECTIVE: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative...

INHIBITION Mitochondria Mitochondrial pyruvate carrier Mitochondrial transport small molecules Humans Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Proteins Monocarboxylic Acid Transporters Pyruvic Acid

Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial...

Adenine nucleotide translocase energetics Mitochondrial transport salt-bridge networks transport mechanism uncoupling protein Animals Biological Transport Cytoplasm Humans Mitochondria Mitochondrial ADP ATP Translocases

Axonal transport is critical for supplying newly synthesized proteins, organelles, mRNAs, and other cargoes from neuronal cell bodies into axons. Its impairment in many neurodegenerative conditions appears likely to contribute...

aging Axon regeneration Axonal Transport Fluorescence live imaging Mitochondrial transport Nicotinamide mononucleotide Adenylyltransferase 2 aging Animals Axonal Transport Axons Female Humans Male Mice Inbred C57BL Mice Transgenic Mitochondria Molecular Imaging Nerve Regeneration Neurodegenerative Diseases Nicotinamide-Nucleotide Adenylyltransferase Optical Imaging Peripheral Nerves Tibial Nerve