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Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer.
Sotiria Tavoulari, Tom JJ Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S King, Daniel TD Jones, ShuJing Ding, Ian M Fearnley, Edmund RS Kunji
Apr 12, 2022
OBJECTIVE: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative...
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A Gallagher, Ramona Woitek, Mary A McLean, Andrew B Gill, Raquel Manzano Garcia, Elena Provenzano, Frank Riemer, Joshua Kaggie, Anita Chhabra, Stephan Ursprung, James T Grist, Charlie J Daniels, Fulvio Zaccagna, Marie-Christine Laurent, Matthew Locke, Sarah Hilborne, Amy Frary, Turid Torheim, Chris Boursnell, Amy Schiller, Ilse Patterson, Rhys Slough, Bruno Carmo, Justine Kane, Heather Biggs, Emma Harrison, Surrin S Deen, Andrew Patterson, Titus Lanz, Zoya Kingsbury, Mark Ross, Bristi Basu, Richard Baird, David J Lomas, Evis Sala, James Wason, Oscar M Rueda, Suet-Feung Chin, Ian B Wilkinson, Martin J Graves, Jean E Abraham, Fiona J Gilbert, Carlos Caldas, Kevin M Brindle
Feb 06, 2020
Mechanism of succinate efflux upon reperfusion of the ischaemic heart.
Hiran A Prag, Anja V Gruszczyk, Margaret M Huang, Timothy E Beach, Timothy Young, Laura Tronci, Efterpi Nikitopoulou, John F Mulvey, Raimondo Ascione, Anna Hadjihambi, Michael J Shattock, Luc Pellerin, Kourosh Saeb-Parsy, Christian Frezza, Andrew M James, Thomas Krieg, Michael P Murphy, Dunja Aksentijević
May 26, 2020
AIMS: Succinate accumulates several-fold in the ischaemic heart and is then rapidly oxidized upon reperfusion, contributing to reactive oxygen species production by mitochondria. In addition, a significant amount of the...
Ischaemia/reperfusion injury MCT1 transporter Mitochondria SUCNR1 Succinate Animals Cells Cultured Disease Models Animal Female Isolated Heart Preparation Male Metabolome Mice Inbred C57BL Mice Knockout Mitochondria Heart Monocarboxylic Acid Transporters Myocardial Infarction Myocardial Reperfusion Myocardial Reperfusion Injury Myocytes Cardiac Oxidation-Reduction Rats Reactive Oxygen Species Receptors G-Protein-Coupled Succinic Acid Sus scrofa Symporters Time Factors
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
Nikita Sushentsev, Mary McLean, Anne Warren, Arnold JV Benjamin, Cara Brodie, Amy Frary, Andrew Gill, Julia Jones, Joshua Kaggie, Benjamin W Lamb, Matthew J Locke, Jodi Miller, Ian G Mills, Andrew N Priest, Fraser JL Robb, Nimish Shah, Rolf S Schulte, Martin Graves, Vincent Gnanapragasam, Kevin Brindle, Tristan Barrett, Ferdia Gallagher
Feb 25, 2022
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
Nikita Sushentsev, Mary A McLean, Anne Y Warren, Arnold JV Benjamin, Cara Brodie, Amy Frary, Andrew B Gill, Julia Jones, Joshua D Kaggie, Benjamin W Lamb, Matthew J Locke, Jodi L Miller, Ian G Mills, Andrew N Priest, Fraser JL Robb, Nimish Shah, Rolf F Schulte, Martin J Graves, Vincent J Gnanapragasam, Kevin M Brindle, Tristan Barrett, Ferdia A Gallagher
Mar 08, 2022