Search
Results: 16
Allostery and dynamics in small G proteins.
The Ras family of small guanine nucleotide-binding proteins behave as molecular switches: they are switched off and inactive when bound to GDP but can be activated by GTP binding in response to signal transduction pathways....
Manipulation of immunometabolism by HIV-accessories to the crime?
CD4-Positive T-Lymphocytes Down-Regulation HIV Infections HIV-1 Host-Pathogen Interactions Human Immunodeficiency Virus Proteins Humans Metabolic Networks and Pathways Monomeric GTP-Binding Proteins SAM Domain and HD Domain-Containing Protein 1 T-Lymphocytes Viral Regulatory and Accessory Proteins Virus Replication
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Petra Mlcochova, Katherine A Sutherland, Sarah A Watters, Cosetta Bertoli, Rob Am de Bruin, Jan Rehwinkel, Stuart J Neil, Gina M Lenzi, Baek Kim, Asim Khwaja, Matthew C Gage, Christiana Georgiou, Alexandra Chittka, Simon Yona, Mahdad Noursadeghi, Greg J Towers, Ravindra K Gupta
Sep 18, 2019
An unresolved question is how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle-associated proteins...
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases.
Ana Masara Binti Ahmad Mokhtar, Samrein BM Ahmed, Nicola J Darling, Matthew Harris, Helen R Mott, Darerca Owen
Apr 27, 2021
Amino Acid Sequence Cell Membrane GTP-Binding Proteins Guanine Nucleotide Dissociation Inhibitors HEK293 Cells Humans Monomeric GTP-Binding Proteins Protein Binding rho GTP-Binding Proteins rho Guanine Nucleotide Dissociation Inhibitor alpha rho Guanine Nucleotide Dissociation Inhibitor beta rho Guanine Nucleotide Dissociation Inhibitor gamma rho-Specific Guanine Nucleotide Dissociation Inhibitors
Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Michael G Hanna, Ioanna Mela, Lei Wang, Robert M Henderson, Edwin R Chapman, J Michael Edwardson, Anjon Audhya
Dec 08, 2015
COPII GTPase endoplasmic reticulum (ER) membrane bilayer membrane transport Amino Acid Substitution Animals COP-Coated Vesicles Caenorhabditis elegans Caenorhabditis elegans Proteins Endoplasmic Reticulum Enzyme Inhibitors GTP Phosphohydrolases GTPase-Activating Proteins Guanosine Triphosphate Guanylyl Imidodiphosphate Humans Lipid Bilayers Membrane Microdomains Microscopy Atomic Force Models Biological Monomeric GTP-Binding Proteins Mutation Organelle Shape RNA Interference Receptor Protein-Tyrosine Kinases Recombinant Proteins Vesicular Transport Proteins ras GTPase-Activating Proteins
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence...
Adaptor Proteins Vesicular Transport Carrier Proteins Endosomes HEK293 Cells HeLa Cells Humans Lysosomes Mechanistic Target of Rapamycin Complex 1 Models Biological Monomeric GTP-Binding Proteins Multiprotein Complexes Nucleotides Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Protein Domains Proteins
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.
Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher, Farida Latif
Jun 13, 2011
Amino Acid Sequence Apoptosis Regulatory Proteins Cell Line Tumor CpG Islands DNA Methylation Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Molecular Sequence Data Monomeric GTP-Binding Proteins Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma Sequence Alignment
Joanna R Watson, Helen M Fox, Daniel Nietlispach, Jennifer L Gallop, Darerca Owen, Helen R Mott
May 05, 2016
BAR domain Cdc42 CIP4 FBP17 TOCA1 WASP actin Endocytosis Nuclear Magnetic Resonance (NMR) Protein-Protein Interaction Animals Carrier Proteins Fatty Acid-Binding Proteins Humans Monomeric GTP-Binding Proteins Protein Binding Protein Domains Protein Structure Quaternary Wiskott-Aldrich Syndrome Protein Neuronal Xenopus Proteins Xenopus laevis
NMR resonance assignments for the active and inactive conformations of the small G protein RalA.
The Ral proteins (RalA and RalB) are small G proteins of the Ras family that have been implicated in exocytosis, endocytosis, transcriptional regulation and mitochondrial fission, as well as having a role in tumourigenesis. RalA...
Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia.
Rem2 is a member of the RGK subfamily of RAS small GTPases. Rem2 inhibits high voltage activated calcium channels, is involved in synaptogenesis, and regulates dendritic morphology. Rem2 is the primary RGK protein expressed in...
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.
Mitochondrial translation defects can be due to mutations affecting mitochondrial- or nuclear-encoded components. The number of known nuclear genes involved in mitochondrial translation has significantly increased in the past...
Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Madalene Earp, Jonathan P Tyrer, Stacey J Winham, Hui-Yi Lin, Ganna Chornokur, Joe Dennis, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Line Bjorge, Natalia Bogdanova, Louise A Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Clareann H Bunker, Ralf Butzow, Ian G Campbell, Karen Carty, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Julie M Cunningham, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Evelyn Despierre, Jennifer A Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Douglas F Easton, Diana M Eccles, Robert P Edwards, Arif B Ekici, Peter A Fasching, Brooke L Fridley, Aleksandra Gentry-Maharaj, Graham G Giles, Rosalind Glasspool, Marc T Goodman, Jacek Gronwald, Philipp Harter, Alexander Hein, Florian Heitz, Michelle AT Hildebrandt, Peter Hillemanns, Claus K Hogdall, Estrid Høgdall, Satoyo Hosono, Edwin S Iversen, Anna Jakubowska, Allan Jensen, Bu-Tian Ji, Audrey Y Jung, Beth Y Karlan, Melissa Kellar, Lambertus A Kiemeney, Boon Kiong Lim, Susanne K Kjaer, Camilla Krakstad, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D Le, Shashi Lele, Jenny Lester, Douglas A Levine, Zheng Li, Dong Liang, Jolanta Lissowska, Karen Lu, Jan Lubinski, Lene Lundvall, Leon FAG Massuger, Keitaro Matsuo, Valerie McGuire, John R McLaughlin, Iain McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Heli Nevanlinna, Kunle Odunsi, Sara H Olson, Irene Orlow, Sandra Orsulic, James Paul, Tanja Pejovic, Liisa M Pelttari, Jenny B Permuth, Malcolm C Pike, Elizabeth M Poole, Barry Rosen, Mary Anne Rossing, Joseph H Rothstein, Ingo B Runnebaum, Iwona K Rzepecka, Eva Schernhammer, Ira Schwaab, Xiao-Ou Shu, Yurii B Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C Southey, Beata Spiewankiewicz, Lara Sucheston-Campbell, Ingvild L Tangen, Soo-Hwang Teo, Kathryn L Terry, Pamela J Thompson, Lotte Thomsen, Shelley S Tworoger, Anne M van Altena, Ignace Vergote, Liv Cecilie Vestrheim Thomsen, Robert A Vierkant, Christine S Walsh, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S Whittemore, Kristine G Wicklund, Lynne R Wilkens, Yin-Ling Woo, Anna H Wu, Xifeng Wu, Yong-Bing Xiang, Hannah Yang, Wei Zheng, Argyrios Ziogas, Alice W Lee, Celeste L Pearce, Andrew Berchuck, Joellen M Schildkraut, Susan J Ramus, Alvaro NA Monteiro, Steven A Narod, Thomas A Sellers, Simon A Gayther, Linda E Kelemen, Georgia Chenevix-Trench, Harvey A Risch, Paul DP Pharoah, Ellen L Goode, Catherine M Phelan
Sep 05, 2018
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and...
Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.
Laurence H Arnold, Harriet CT Groom, Simone Kunzelmann, David Schwefel, Sarah J Caswell, Paula Ordonez, Melanie C Mann, Sabrina Rueschenbaum, David C Goldstone, Simon Pennell, Steven A Howell, Jonathan P Stoye, Michelle Webb, Ian A Taylor, Kate N Bishop
Mar 21, 2019
SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse...
Biocatalysis Cell Line Chromatography Gel Chromatography High Pressure Liquid Crystallography X-Ray Flow Cytometry HIV-1 Humans Monomeric GTP-Binding Proteins Phosphorylation Protein Conformation Reverse Transcriptase Polymerase Chain Reaction SAM Domain and HD Domain-Containing Protein 1 Spectrophotometry Atomic
Bioblockades join the assault on small G protein signalling.
Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using...
G protein Macrocycle Peptidomimetic Ras Therapeutic Animals Drug Discovery Humans Monomeric GTP-Binding Proteins Multigene Family Peptides Protein Binding Protein Interaction Domains and Motifs Protein Transport Signal Transduction Son of Sevenless Proteins Structure-Activity Relationship ras Proteins