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Results: 16
Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies.
Gesine Respondek, Max-Joseph Grimm, Ines Piot, Thomas Arzberger, Yaroslau Compta, Elisabet Englund, Leslie W Ferguson, Ellen Gelpi, Sigrun Roeber, Armin Giese, Murray Grossman, David J Irwin, Wassilios G Meissner, Christer Nilsson, Alexander Pantelyat, Alex Rajput, John C van Swieten, Claire Troakes, Günter U Höglinger, Movement Disorder Society-Endorsed Progressive Supranuclear Palsy Study Group
Oct 31, 2019
BACKGROUND: The Movement Disorder Society criteria for progressive supranuclear palsy introduced the category "probable 4-repeat (4R)-tauopathy" for joint clinical diagnosis of progressive supranuclear palsy and corticobasal...
Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.
Isabelle Lavenir, Daniela Passarella, Masami Masuda-Suzukake, Annabelle Curry, Janice L Holton, Bernardino Ghetti, Michel Goedert
Sep 15, 2020
Synucleinopathies [Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous α-synuclein assemblies in nerve cells and glial cells. We compared the abilities of brain extracts...
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Dec 22, 2021
Abstract: Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same...
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.
Edwin Jabbari, Negin Holland, Viorica Chelban, P Simon Jones, Ruth Lamb, Charlotte Rawlinson, Tong Guo, Alyssa A Costantini, Manuela MX Tan, Amanda J Heslegrave, Federico Roncaroli, Johannes C Klein, Olaf Ansorge, Kieren SJ Allinson, Zane Jaunmuktane, Janice L Holton, Tamas Revesz, Thomas T Warner, Andrew J Lees, Henrik Zetterberg, Lucy L Russell, Martina Bocchetta, Jonathan D Rohrer, Nigel M Williams, Donald G Grosset, David J Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P Nigel Leigh, Alistair Church, Michele Tm Hu, John Woodside, Henry Houlden, James B Rowe, Huw R Morris
Feb 26, 2020
IMPORTANCE: Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages and are often...
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.
Jennifer A Macdonald, John L Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Nov 24, 2021
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case...
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Jun 07, 2022
BACKGROUND: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates...
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.
Therése Klingstedt, Bernardino Ghetti, Janice L Holton, Helen Ling, K Peter R Nilsson, Michel Goedert
Dec 02, 2020
Synucleinopathies [Parkinson's disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions. We...
Luminescent Conjugated Oligothiophene Multiple System Atrophy neurodegeneration Parkinson’s disease Spectral analysis α-synuclein Aged Aged 80 and over Diagnosis Differential Female Fluorescent Dyes Humans Luminescent Measurements Male Middle Aged Multiple System Atrophy Optical Imaging Parkinson Disease Thiophenes ALPHA-SYNUCLEIN
Living in Promiscuity
Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to presynaptic terminals. Due to elevated conformational plasticity, which can be affected by environmental factors, in addition to undergoing...
Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes.
Edwin Jabbari, John Woodside, Tong Guo, Nadia K Magdalinou, Viorica Chelban, Dilan Athauda, Andrew J Lees, Thomas Foltynie, Henry Houlden, Alistair Church, Michele Tm Hu, James B Rowe, Henrik Zetterberg, Huw R Morris
Sep 06, 2019
OBJECTIVE: The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson's disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using...
Pre-diagnostic cognitive and functional impairment in multiple sporadic neurodegenerative diseases.
Nol Swaddiwudhipong, David J Whiteside, Frank H Hezemans, Duncan Street, James B Rowe, Timothy Rittman
Oct 12, 2022
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.
Jennifer A Macdonald, John L Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Jan 05, 2022
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case...
Microglia Multiple System Atrophy neurodegeneration seeded assembly α-synuclein Aged Animals Animals Genetically Modified Hindlimb Humans Immunohistochemistry Male Mice Neurologic Mutants Microglia Motor Neurons MOVEMENT DISORDERS Multiple System Atrophy Mutation Neurodegenerative Diseases Neurons Paralysis ALPHA-SYNUCLEIN
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.
Therése Klingstedt, Bernardino Ghetti, Janice L Holton, Helen Ling, K Peter R Nilsson, Michel Goedert
Jan 06, 2020
Synucleinopathies [Parkinson's disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions. We...
The basal ganglia in perceptual timing
The timing of perceptual events depends on an anatomically and functionally connected network comprising basal ganglia, cerebellum, pre-frontal cortex and supplementary motor area. Recent studies demonstrate the cerebellum to be...
'Under pressure'
autonomic Cognition LEWY BODY MULTISYSTEM ATROPHY Parkinson's Disease cerebral small vessel diseases Cognitive Dysfunction Humans Hypotension Orthostatic Hypoxia-Ischemia Brain Lewy Body Disease Longitudinal Studies Magnetic Resonance Imaging Mental Status Schedule Multiple System Atrophy Neuroglia Parkinson Disease Positron Emission Tomography Computed Tomography Risk Factors Statistics as Topic ALPHA-SYNUCLEIN